EuCleo | 11 points
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol (2002)Guzzo CA, Furtek CI, Porras AG, et al. Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. [PDF] J Clin Pharmacol 2002; 42: 1122–33.
ABSTRACT:
Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double‐blind, placebo‐controlled, dose escalation study. Subjects (n = 68) were assigned to one of four panels (3:1, ivermectin/placebo): 30 or 60 mg (three times a week) or 90 or 120 mg (single dose). The 30 mg panel (range: 347–594 μg/kg) also received a single dose with food after a 1‐week washout. Safety assessments addressed both known ivermectin CNS effects and general toxicity. The primary safety endpoint was mydriasis, accurately quantitated by pupillometry. Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA‐approved dose of 200 μg/kg. All dose regimens had a mydriatic effect similar to placebo. Adverse experiences were similar between ivermectin and placebo and did not increase with dose. Following single doses of 30 to 120 mg, AUC and Cmax were generally dose proportional, with tmax ∼4 hours and t1/2 ∼18 hours. The geometric mean AUC of 30 mg ivermectin was 2.6 times higher when administered with food. Geometric mean AUC ratios (day 7/day 1) were 1.24 and 1.40 for the 30 and 60 mg doses, respectively, indicating that the accumulation of ivermectin given every fourth day is minimal. This study demonstrated that ivermectin is generally well tolerated at these higher doses and more frequent regimens.
[-] stereomatch | 4 points
This is the 2002 study that Dr Tess Lawrie was mentioning in her interview on Dr Been or Dr John Campbell's Youtube channel - that even Merck in 2000-something published a study which showed safety at 10x usual dosing:
Paid paper - full paper available at:
https://sci-hub.st/https://doi.org/10.1177/009127002237994
here are the author affiliations:
From Merck Research Laboratories, Blue Bell and West Point, Pennsylva-nia, and Terlings Park, United Kingdom (Dr. Guzzo, Ms. Furtek, Dr. Porras,Dr. Chen, Mr. Tipping, Ms. Clineschmidt, Dr. Sciberras, Dr. Hsieh) andClinical Pharmacology Associates, Miami, Florida (Dr. Lasseter). This studywas sponsored by a grant from Merck Research Laboratories, a division ofMerck & Co., Inc. Dr. Lasseter has no financial interest in Merck & Co. Dr.Sciberras was employed by Merck & Co., Inc., at the time of the study. Allother authors are currently employed by Merck & Co., Inc. Submitted forpublication March 5, 2002; revised version accepted June 30, 2002. Ad-dress for reprints: Ms. Christine Furtek, Merck & Co., Inc., BLX-29, P.O. Box4, West Point, PA 19486.
This does not rule out rare problems in specific individuals, such as those with impairment with their blood brain barriers. This is a relatively small study. But I thought it was worth flagging as a reference.
[-] loonygecko | 6 points
The geometric mean AUC of 30 mg ivermectin was 2.6 times higher when administered with food.
So absorption was much better with food? Interesting, seems like the medical community was recommending taking it on an empty stomach. As per safety, as best as I can tell, it's after than aspirin really. But obviously you don't want to take stupid amounts of aspirin either.
You take it on an empty stomach when you want to get rid of intestinal parasites. It may make more sense to take it with food if you are trying to kill a particular nasty virus in your system.
[-] loonygecko | 1 points
Makes sense.
Not just food, but high fat one: https://pubmed.ncbi.nlm.nih.gov/26918286/ and also with alcohol (see Dr. Hector Carvallo, first physician with in vivo ivermection internationally published results).
[-] loonygecko | 2 points
Oh no, i'll be forced to eat a high fat meal! :-)
Like any drug, even with one as safe as Ivermectin, dosing and patient history is important. So we lean on the clinical experience of physicians for this. When physicians become government and hospital 'yes' people, people will self administer and unfortunately there are people who aren't smart that just think 'more is better'.
I am lucky that I've found pretty good physicians for my family's care. They are aware of my scientific background and how well read I am on specific conditions. Because they are decent, they realize that my health (and family's) is my responsibility and I use them as a tool to assist me. In many cases it's a sanity check because they are still (sometimes) the SME (subject matter experts), but often still are restricted in the framework of the government and their peers.
[-] tikapikalol | 7 points | Apr 25 2021 02:30:48
Ya, this was the study I got suspended for on Twitter.
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[-] loonygecko | 5 points | Apr 25 2021 02:50:29
Social media actually has been very aggressive when you post actual evidence of your opinion if it's contrary to the narrative, it's truly clown world. On the flip side, you can post any kind bs lies if it supports the narrative (for instance you could say vaccines have zero side effects ever) and they will not censor you for that at all.
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[-] biskitwheels | 1 points | Apr 26 2021 22:33:56
You can't even ask why vitamins aren't recommended (in the case of Vitamin-D, the FDA advises against its use).
Search Biden's Covid plan and the CDC webpage for guidance.
You'll find there is nothing provided as far as preventative measures other than hands, distance and masks. This is not on accident.
The vaccine has always been their only goal. Western medicine needs to be seen by a doctor
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[-] loonygecko | 1 points | Apr 27 2021 01:25:28
Western medicine needs to be seen by a doctor
Yes it is horrible and doctors have for decades at least given lip service to trying to live a healthy livestyle, get good nutrition etc. Now suddenly even that is banned? Truly clown world.
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