Does Ivermectin work because the coronavirus is a bat(animal) virus? and since Ivermectin is used to treat bacterial infections in animals it makes sense why it would work.

[-] TehCaster | 5 points | Apr 14 2021 22:02:55

No, that's not the reason. Also it doesn't treat bacterial infections, it treats parasites.

[-] Sanpaku | 5 points | Apr 14 2021 22:21:49

Best hypothesis I've seen for why ivermectin may be effective as an wide spectrum antiviral is through inhibiting importin, preventing transport of viral product proteins into the cell nucleus.

Yang et al, 2020. The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer. Antiviral research, 177, p.104760.

There are other possible mechanisms, like interacting with the ACE2 receptor or proteases 3CLpro and PLpro.

Francés-Monerris et al 2020. Has Ivermectin Virus-Directed Effects against SARS-CoV-2? Rationalizing the Action of a Potential Multitarget Antiviral Agent.

This would have nothing to do with SAR-CoV-2's likely origins as a bat coronavirus. Antiviral activity for ivermectin has been found against HIV-1, dengue virus (DENV), Zika virus, West Nile virus, Venezuelan equine encephalitis virus, Chikungunya virus, Pseudorabies virus, adenovirus, most of which have non-bat natural hosts.

Jans and Wagstaff, 2020. Ivermectin as a broad-spectrum host-directed antiviral: the real deal?. Cells, 9(9), p.2100.

[-] magebane1 | 1 points | Apr 16 2021 21:54:54

Whiteboard Doctor covers the mechanisms of actions extremely well : https://www.youtube.com/watch?v=sArj3NY2i30

The 3 highlights I took away from it:

Enters the cell nucleus and inhibits viral replication
Restores communication (suppresed by Sars-Cov-2) with neighbouring cells (so the immune system can identiy and respond quicker to the infection and not wait until it's overrun.
Potent anti-inflammatory to avoid the cytokine storm (also believed to be caused by the virus in (2).

[-] dhmt | 1 points | Apr 17 2021 16:32:34

I watched the whole video. None of the three highlights you mention are in there. The video is mostly a timeline of drugs tried for COVID.

I am very interested in the video you intended to post - looking for mechanisms of action.

[-] magebane1 | 2 points | Apr 17 2021 17:09:11

Sorry bout that let me find the actual video...I figured it was on the playlist

[-] dhmt | 1 points | Apr 17 2021 17:30:57

No prob! Thanks for helping.

[-] magebane1 | 2 points | Apr 17 2021 17:43:58

Ok this is an early one but talks a bit more about the mechanisms. In fact the video I was thinking is not whiteboard doctor, need more time to find it but I will (and bookmark it this time): For now:

https://www.youtube.com/watch?v=9bgcgiutrw8

[-] magebane1 | 2 points | Apr 17 2021 17:49:15

Got it!

https://www.youtube.com/watch?v=GZoBAuR4ajs&t=824s

[-] dhmt | 1 points | Apr 17 2021 21:42:04

Great! And linked to the right timestamp, too. Thank you.

[-] magebane1 | 2 points | Apr 17 2021 21:56:12

Oops wasn't intentional. But I recommend the whole video when you have time. Good amount of detail on the mechanism of action.

[-] dhmt | 2 points | Apr 17 2021 22:02:49

Aah. I use that timestamp technique a lot, because I am dealing with very smart colleagues, but they are also impatient jerks sometimes:

They: "Prove to me that ivm works";
Me: "Here is a link to a video";
They: "I don't have time to watch a 20 minute video!";
Me: "But I linked to the exact timestamp, because I know you are busy!".

Of course, these people want a randomized controlled study report authored by Nobel prize winners, which they would not understand anyway, and they would complain "that takes too long too read". Fuck right off! (not you, my colleagues).

But now I am ranting.

I will be shoving that BC CDC document in their faces, thank you very much.

[-] magebane1 | 1 points | Apr 18 2021 00:29:08

Yeah...unfortunately these people will debate you for hours, but won't watch a 15 or 20 min video from accredited experts. Systemic problem with out society, we trust sensational journalism over science.

'When you don't have time, but you just rewatched Season 1 of Ozark". sure :P

Yep I'm in BC