Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity - Cell journal paper (Mar 23, 2021) - implications for continued need for early treatments and their continued relevance

[-] stereomatch | 5 points | Mar 16 2021 16:56:06

This suggests early treatment using Ivermectin, Famotidine etc. and steroids at day 7-8/oximeter fall will remain relevant as a safety net in the future.

https://www.cell.com/cell/fulltext/S0092-8674(21)00298-1 Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

March 12, 2021

Highlights

Numerous variants of SARS-CoV-2 harboring mutations in spike have arisen globally
mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus
Cross-neutralization of strains with receptor binding domain (RBD) mutations is poor
Both RBD and non-RBD mutations mediate escape from vaccine-induced humoral immunity

Summary

Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.

[-] Grand-Pay8061 | 1 points | Mar 16 2021 21:56:02

Any thoughts on the work of Andreas Kalcker and Chlorine Dioxide at 3000ppm in aqueous solution. Bolivia accepts it as a disease mitigation substance.

https://andreaskalcker.com/en/coronavirus/covid-treatment.html

You can join the telegram group but most of the communications is in spanish...can use Google translate and a little cut and paste and it works.