stereomatch | 36 points | Mar 15 2021 11:14:56

Dr. Satoshi Omura, Nobel Laureate and co-discoverer of Ivermectin appeals for it's special approval, so it can be used for the treatment of COVID-19.

https://www.dailyshincho.jp/article/2021/03141057/?all=1 Dr. Satoshi Omura, the discoverer of "ivermectin", complains that "special approval should be given". Weekly Shincho March 11, 2021 issue

Google Translate:

"There are no serious side effects ..."

Domestic vaccination has begun, but at the same time therapeutic agents will be important. "Ivermectin" discovered by Dr. Satoshi Omura, who won the Nobel Prize, has been reported to have remarkable effects from all over the world, and Dr. Omura himself appeals that special approval should be given.

"Clinical trials take time, but because of the abundance of overseas data, it may not be necessary to conduct clinical trials in Japan. Experts have given numbers and announced that they are working. Therefore, I would like you to approve the special approval with that. If you do not use it here, what is the special approval system for? Some people will die if they are waiting for a clinical trial. "

It is none other than Dr. Omura who complains so, and explains ivermectin.

"The original substance called evermectin was discovered in the microorganisms isolated from the soil collected near the golf course in Kawana, Izu, and brought back to the laboratory. The microorganisms cultivated for evermectin all over the world are If you trace the origin, it was taken from this soil. I was involved in the area where it works for nematodes, and after that, many overseas researchers have announced that it works for viruses and cancer. It's no wonder why the drug is a virus, but it's no wonder that Ibermectin is classified as a macrolide antibiotic, and this family of drugs often has second and third effects, such as colds. Erythromycin, which is prescribed in Izu, is also a macrolide antibiotic, but it has the same effect as motilin, a hormone that helps digestion, and it also has an anti-inflammatory effect and is effective for asthma. Also, there are no reports of serious side effects. The reason why this medicine is distributed in Africa not by doctors and nurses but mainly by volunteers is that there is no danger. People weighing 50 to 60 kg can take 3 to 4 3 mg tablets. Well, it's amazing that this small amount works. "

I can't find any treatises that say it doesn't work

The action of ivermectin on the new corona,

"It has been announced that it not only suppresses the growth of the virus, but also works on the body to suppress inflammation when infected with the virus, and also has the effect of activating the function of killing the virus by the immune system. The paper was withdrawn due to a mistake by an information provider, and some people questioned its effectiveness. However, in reality, there are no papers that say that the virus does not work for the new corona. In Peru. The mortality rate in the states that took the virus decreased steadily, but it did not decrease in the state that did not take it, and if the president saved the change of drinking, the mortality rate increased in the state that was taking the virus. It has also been reported. "

Effective in preventing infection and reducing symptoms

Professor of Kitasato University, Director of Infection Control Research Center, Satoshi Omura Memorial Research Institute, and Representative of COVID-19 Countermeasures Kitasato Project, who participated in the meeting with Dr. Omura, Chairman of the Tokyo Medical Association, Haruo Ozaki and Vice President of Toru Tsunoda Hideaki Hanaki

"Chairman Ozaki was studying the mechanism of action of ivermectin very well. He kindly agreed to cooperate with the clinical trial under the guidance of Professor Kunihiro Yamaoka, who participated with us."

And explains the effect of ivermectin as follows.

"It blocks the binding of the virus to the cells, and even if the virus enters the body, it blocks the replication of the virus. It is called importin, which carries the protein of the virus into the nucleus. This is because it inhibits the action of transport substances. It cannot replicate because viral proteins cannot enter the nucleus. These two mechanisms of action are effective in both infection prevention and symptom relief. "

pg. 2

"Safety has been shown, but clinical trials are lacking."

Of course, there are also cautious voices. Professor Takeshi Terashima of Tokyo Dental College Ichikawa General Hospital

"It's an advantage that it's been used for decades and has been widely shown to be safe. It's also an advantage that ivermectin is a drug that home caregivers don't currently take. 3 milligrams for parasites. I think that it will be used in the same way for the new corona by taking 4 tablets at a time. Once the effectiveness is shown, there are advantages in terms of burden on patients and medical institutions. large"

On the other hand, "the data is inadequate," he explains.

"It is true that there are reports in various countries around the world suggesting the effectiveness of the new corona. In Bangladesh, the number of days until the virus disappears is 15 to 4 days and the length of hospital stay is 15 days in the population who drank ivermectin. It was reported that the mortality rate was reduced from 6.8% to 0.9% by shortening to 9 days. Peruvian data show that in areas where high doses of ivermectin were distributed, cases were compared to those in other areas. The number and the number of deaths have decreased significantly. However, probably because ivermectin is easy to obtain and use, the data is available only in South America and Southeast Asia, and it is reliable to show the effectiveness of the drug. There are few papers in the journal. I think that proper clinical trials have not been conducted yet. Another concern is that pharmaceutical companies are not active in clinical trials and are led by doctors. It can make it difficult to conduct reliable clinical trials. " "Healed in no time" in all 23 cases

However, Professor Terashima says, "As far as I know, there are only a few examples of using ivermectin," but in fact, it is also in Tokyo.

"Ivermectin has been used in 23 cases so far, and everyone has been cured in no time."

Said Masafumi Tabuchi, a former lecturer at the University of Tokyo School of Medicine and director of the Nakameguro Gastroenterological Clinic.

"Half of the 23 people tested positive for antigens, about half had close contacts, and suspected corona infection due to symptoms such as fever and olfactory dysfunction, one at another hospital. Those who tested positive for the PCR test were those who drank early after the onset of symptoms in a day or two, and those with complications improved in a day or four. "

How to prescribe

"I prescribe it with a drug called camostat and clarithromycin. Clarithromycin is a drug used for diseases of the upper respiratory tract such as colds, and it is said that it is widely effective against bacteria existing in the upper respiratory tract. Since the metabolic pathway is exactly the same as that of Ibermectin, co-administration makes it difficult for the cells to wash out, that is, to disappear over time, and probably keeps the intracellular concentration of Ibermectin high. As a result, I think it has a strong effect. On the other hand, camostat prevents the virus from entering the cell by a mechanism different from that of Ibermectin. In this way, it hits the virus with multiple drugs with different mechanisms of action. Is the basic

"From a standpoint, you shouldn't talk with emotions ..."

How advanced is the clinical trial? According to Professor Yamaoka of Kitasato University, who was in charge of the clinical trial of ivermectin, which was mentioned in Professor Hanaki's story.

"We planned a clinical trial in March last year and started it in September. In order to investigate the growth inhibitory effect of the virus, we divided 240 people into two and administered ivermectin and (placebo) placebo, respectively. It was scheduled to end in March of this year, but it has been extended. Since November, the number of severely ill patients has increased and the number of mildly ill patients to be studied has decreased. , Tokyo also introduces medical institutions that cooperate with clinical trials. "

However, perhaps because of his position, Professor Yamaoka

"Ivermectin is a drug that has been taken by 4 billion people so far, but there is no guarantee that it will be okay for patients with the new corona. The data that it works in emerging countries is interesting, but placebo in those countries. It has not been compared to the treatment group and the level of evidence is low. "

Be cautious. However, with caution, the following pride looks into his face.

"From a standpoint, I shouldn't talk about it emotionally, but I'm looking forward to ivermectin. It would be great if it was confirmed that the drug taken by 4 billion people was not so common and that it suppressed the growth of the virus. Professor Omura Was discovered in Japan, and I think the Japanese should prove its safety and effectiveness. I think it is my role to provide scientific evidence to the data of emerging countries. "

Also used in India to contain infection

Let's ask Professor Hanaki mentioned above to explain the current "evidence".

"Ivermectin has been shown to be effective in mild to severe cases, and an analysis of 35 studies showed 84% improvement in early treatment, 39% improvement in late treatment, and 90% improvement in prevention, officials said. In India, which announced containment of infection, ivermectin was taken from the beginning. In Peru, Venezuela, Egypt, etc., the government has already approved it. In the United States, NIH (National Institute of Public Health) opposed its use until a while ago. However, he changed his position to neither recommend nor disagree, and was able to prescribe it to 50,000 people in a week. According to a study by Professor Andrew Hill of the University of Liverpool, the number of deaths in 650 in the ivermectin group was It was 2.1% in 14 and 9.5% in the non-administered group 597. According to Harvard Medical School and others, the lethality rate of 704 patients in the treated group was 1.4%, and the same number of non-administered groups was 8. 5%. Only for Venezuelan wearers, the difference is even wider, with 7.3% and 21.3%. "

Prescriptions can be made at the discretion of doctors in Japan, but Professor Hanaki said

"In the unlikely event that a patient experiences serious side effects when used outside the scope of application, the prescribing doctor will be held liable. That may be one of the reasons why prescribing in Japan is not progressing. There have been reports of sudden deaths of home care recipients, and I think there are some patients who are anxious. I hope that even those people will be able to distribute it. "

I urgently appeal. The silver bullet may actually be at your feet. With the delay in securing vaccines and the question mark for smooth inoculation, why not approve the special case? Confirmation of safety is important, but both home caregivers and those who are cornered under a state of emergency are in a situation where safety is not ensured.

From the special feature "Ivermectin", a silver bullet that prevents "sudden death during home medical treatment" even if you fail to secure "Corona vaccine"

permalink