fieldsofcoral | 36 points
RESULTS: Ivermectin shows clinical benefits in mild to moderate COVID19: A randomised controlled double-blind, dose-response study in Lagos (Oxford University journal 18th Feb, 21)Next up the WHO study. Then maybe a year later NIH might finally update their guidance after it's too late.
Where's that article from that idiot of a reporter who decided it wasn't ivermectin that helped him, this should be forwarded.
[-] PepeLePewwwww | 2 points
If the implications of this spot-on reply weren’t so sad it would be hilarious. Thanks my friend
[-] fieldsofcoral | 6 points | Feb 18 2021 19:32:56
(Tldr: testing clearance rates for mild moderate covid positive, around 20 people per group. 9.1 days mean for control, 6.0 days for 6mg ivermectin, 4.6 days for 12mg ivermectin. Good news! Front-line journal as well, hard to ignore.)
Abstract Introduction In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS - CoV- 2 viral replication, but questions remained as to In-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19.
Methods We conducted a translational proof of concept (PoC) randomized, double blind placebo controlled, dose response, parallel group study of IV efficacy in RT - PCR proven COVID 19 positive patients. 62 patients were randomized to 3 treatment groups. (A) IV 6mg regime, (B)IV 12 mg regime (given Q84hrs for 2weeks) (C, control) Lopinavir/Ritonavir. All groups plus standard of Care.
Results The Days to COVID negativity [DTN] was significantly and dose dependently reduced by IV (p = 0.0066). The DTN for Control were, = 9.1+/-5.2, for A 6.0 +/- 2.9, and for B 4.6 +/-3.2 . 2 Way repeated measures ANOVA of ranked COVID 19 +/- scores at 0, 84, 168, 232 hours showed a significant IV treatment effect (p = 0.035) and time effect (p < 0.0001). IV also tended to increase SPO2% compared to controls, p = 0.073, 95% CI - 0.39 to 2.59 and increased platelet count compared to C (p = 0.037) 95%CI 5.55 - 162.55 × 103/ml. The platelet count increase was inversely correlated to DTN (r = -0.52, p = 0.005). No SAE was reported.
Conclusions 12 mg IV regime may have superior efficacy. IV should be considered for use in clinical management of SARS-Cov-2, and may find applications in community prophylaxis in high-risk areas.
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