foggynotion | 16 points | Feb 10 2021 16:20:07

Found this 2013 paper where they investigate using Calendula flower extract as an addition to ivermecton therapy. They also investigate adding NAC to ivermectin as well. The paper is for oxidative recovery rates of dogs that have mange, but the mechanisms of action of CFE with antioxidant and anti-inflammatory properties seems like it would have a lot of potential in battling the SARS-CoV-2 virus as well. https://www.hindawi.com/journals/isrn/2013/657672/:

"As we found that the clinical recovery and parasitological cure rates were faster in ivermectin + CFE treated dogs, the supplementation of CFE along with ivermectin might have shifted the altered oxidant/antioxidant balance towards normalcy with a faster rate. Recently, we have demonstrated a faster clinical recovery and shifting of oxidative imbalance toward normalcy by adjunct therapy with antioxidants in Psoroptes cuniculi-infested rabbits [49]. The restoration of antioxidants and amelioration of lipid peroxidation in CFE treated dogs might be involved in faster clinical and parasitological cure. Lipid peroxidation can be harmful for skin due to alterations in the structure and permeability [37]. CFE might have a complementary effect with ivermectin as compromised antioxidant defense systems of infested dogs and healing effect of ivermectin remarkably improved by day 28 after therapies. Findings of the present study indicate a potential role of CFE in faster clinical recovery in Sarcoptes-infested dogs. Previous scientific reports have demonstrated the skin healing activities of Calendula in various skin disorders due to its multitude of properties; for instance, anti-inflammation, stimulation of epithelialization, and an increase in gelatinase activities [22, 41]. Results of the present study signify the faster parasitological cure; in this context, CFE might have indirectly augmented the miticidal effect of ivermectin. This may be an outcome of various activities including immunomodulatory and antioxidant actions of CFE, promoting the animal body to combat against the Sarcoptes mites."

Then I found this paper that studies specifically the potential benefits of Calendua Flower Extract against SARS_CoV-2: In-Silico approach for identification of effective and stable inhibitors for COVID-19 main protease (Mpro) from flavonoid based phytochemical constituents of Calendula officinalis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441784/

"Our in silico (Virtual molecular docking and Molecular dynamics simulation) studies pointed out that flavonoid based phytochemicals of calendula (rutin, isorhamnetin-3-O-β-D, calendoflaside) may be highly effective for inhibiting Mpro which is the main protease for SARS-CoV-2 causing the deadly disease COVID-19. "

I tweeted a few of the main ivermectin researchers out there about this, maybe they'll take a look.. In the mean time I bought a tincture off amazon nonetheless and add 30 drops to a glass of water everyday. I read about this last summer and was able to get calendula seeds (aka pot marigold), you grow the flower and make tea with the flower. Got some sprouting as we speak haha! Most hardware stores have seeds for this flower since it is very commonly grown, but overall seeds and seed companies are selling out of pretty much all seeds fast this year. Very easy flower to grow just about anywhere if you got dirt and water. Easy in containers if you just have balcony. Just passing this info along. NAC would be a separate post but I take it as well. Take care everyone.

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