Medcram (Dr Seheult) covers some of the questions people have. The video doesn't cover Ivermectin - but am providing for completeness as in the next video he and Dr John Campbell do discuss Ivermectin and then some of these same issues.
Rough transcript of the interesting parts of the video (my comments are in brackets):
oximeter needed - because of happy hypoxia
(Note: I agree here - for some early treatment/home treatment cases it is not clear when they had first symptoms - either they had mild symptoms or their recollection is spotty - this creates problems for estimating timing for when it is safe to start steroids to preempt organ/lung damage - usually this is day 7-8 according to MATH+ protocol when the live virus is dead in nearly all people - but if timing info is imprecise this can lead to uncertainty in when to start steroids - in such cases it may be left to just monitoring oximeter levels for falling oxygen saturation - or alternatively even if they have 98 but high pulse rates 100+ even at rest - or alternatively by starting a short steroids course after you are sure 8 days "must" have passed since patient had minor first symptoms or exposure and counting approx 5 days would have taken for virus symptoms ie typically where viral peak occurs - though I suppose it is possible that if initial viral inoculum is low that it could be longer than 5 days for peak to occur and thus first symptoms)
15:20 - vitamin d3 is probably the safest fat soluble vitamin there is
study out of India where have for 7 days then to normal levels
15:30 - any other vitamins take with vitamins d3
Some evidence vitamin k2
But vitamin k are counterproductive if taking blood thinners
Magnesium some studies mention that and dosing
17:10 - Quercetin risk low so not hurt if has antiviral potential as zinc ionophore
Medcram #59 video where mentioned these
NAC - oxidative stress theory
earlier studies that if getting 7 hours of sleep before vaccination
Then antibody response is much more robust
Hours of sleep before midnight worth more
Slow wave sleep
20:50 - oxidative stress etc
Melatonin - help for sleep and for antioxidants for oxidative stress
Zinc - still recommending it but not more than 40mg elemental zinc per day
26:00 - patients with severe disease had more viral load (or viral debris) and delayed interferon response
29:20 - that is why I was hesitant to treat a fever that was lower than 103F
(Note: here he is echoing what Dr John Campbell been saying to not use paracetamol/Panadol as it lowers and masks true state - and lower fever weakens anti virus response - while Dr Seheult has from the start emphasized in his earlier videos how temperature therapy - hydrotherapy - as used in 1918 pandemic at some sanitoriums produced good results)
thermal impact of fever - hyperthermia
it seems the fever is enhancing the very part of the immune system that is required to put an end to the progression of covid19
30:00 - cold exposure also seems to help innate immune system
30:50 - earlier study that when increases temperature it enhanced interferon-gamma
10 fold increase in interferon-gamma at 39 C
32:20 - 1929 Nobel prize - malaria infecting to cure neurosyphilis
1928 introduction of penicillin overshadowed this work
35:30 - strategies for home treatment if patient sent home by hospital
37:30 - ventilation more important than wiping down surfaces - probably not a huge vector
(Note: this is what has been apparent from the start - that aerosol/breathing/coughs/sneeze are the vector and conditions like stagnant room air - surfaces ie "fomites" are not going to be huge factor because virus dies and because touching your nose is not the same level of viral inoculum as sending viral particles or droplets into your nasal cavity or lungs for an extended period when sitting in room with stagnant air with others - however washing hands has been convenient proxy for that for soap sellers - but may indirectly have benefited for raising overall awareness)
Video and it's description section:
https://www.youtube.com/watch?v=vN30emwcNS4
If You Get COVID 19: Optimize Immune System (Vitamin D, Monoclonal Antibodies, NAC, Quercetin etc.)
Jan 3, 2021
Medcram
Professor Roger Seheult, MD gives practical strategies if you test positive for COVID-19 (or are in contact with someone who tests positive) including:
0:00 Video Intro
1:11 Use of a pulse oximeter at home to monitor oxygen saturation and possible COVID pneumonia
3:02 How to choose a pulse oximeter
3:34 Tips for using a pulse oximeter
5:35 Who qualifies for monoclonal antibodies (bamlanivimab, casirivimab, and imdevimab from Lily and Regeneron), how they work, and how effective are they?
11:11 The varying level of data/study strength for different strategies
12:55 Vitamins that may boost immune function: Vitamin D, NAC, Vitamin C, Quercetin, Zinc, Vitamin K-2, Magnesium
18:27 The importance of adequate sleep (Melatonin discussed)
21:57 Core body temperature elevation (the data on hydrotherapy and sauna use)
35:11 Isolation strategies at home: ventilation, HEPA filtration, mask-wearing
37:32 Summary of strategies to consider if testing positive for COVID 19
Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com
He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine
Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com
[-] stereomatch | 2 points | Jan 08 2021 10:51:55
Medcram (Dr Seheult) covers some of the questions people have. The video doesn't cover Ivermectin - but am providing for completeness as in the next video he and Dr John Campbell do discuss Ivermectin and then some of these same issues.
Rough transcript of the interesting parts of the video (my comments are in brackets):
oximeter needed - because of happy hypoxia
(Note: I agree here - for some early treatment/home treatment cases it is not clear when they had first symptoms - either they had mild symptoms or their recollection is spotty - this creates problems for estimating timing for when it is safe to start steroids to preempt organ/lung damage - usually this is day 7-8 according to MATH+ protocol when the live virus is dead in nearly all people - but if timing info is imprecise this can lead to uncertainty in when to start steroids - in such cases it may be left to just monitoring oximeter levels for falling oxygen saturation - or alternatively even if they have 98 but high pulse rates 100+ even at rest - or alternatively by starting a short steroids course after you are sure 8 days "must" have passed since patient had minor first symptoms or exposure and counting approx 5 days would have taken for virus symptoms ie typically where viral peak occurs - though I suppose it is possible that if initial viral inoculum is low that it could be longer than 5 days for peak to occur and thus first symptoms)
15:20 - vitamin d3 is probably the safest fat soluble vitamin there is
study out of India where have for 7 days then to normal levels
15:30 - any other vitamins take with vitamins d3
Some evidence vitamin k2
But vitamin k are counterproductive if taking blood thinners
Magnesium some studies mention that and dosing
17:10 - Quercetin risk low so not hurt if has antiviral potential as zinc ionophore
Medcram #59 video where mentioned these
NAC - oxidative stress theory
earlier studies that if getting 7 hours of sleep before vaccination
Then antibody response is much more robust
Hours of sleep before midnight worth more
Slow wave sleep
20:50 - oxidative stress etc
Melatonin - help for sleep and for antioxidants for oxidative stress
Zinc - still recommending it but not more than 40mg elemental zinc per day
26:00 - patients with severe disease had more viral load (or viral debris) and delayed interferon response
29:20 - that is why I was hesitant to treat a fever that was lower than 103F
(Note: here he is echoing what Dr John Campbell been saying to not use paracetamol/Panadol as it lowers and masks true state - and lower fever weakens anti virus response - while Dr Seheult has from the start emphasized in his earlier videos how temperature therapy - hydrotherapy - as used in 1918 pandemic at some sanitoriums produced good results)
thermal impact of fever - hyperthermia
it seems the fever is enhancing the very part of the immune system that is required to put an end to the progression of covid19
30:00 - cold exposure also seems to help innate immune system
30:50 - earlier study that when increases temperature it enhanced interferon-gamma
10 fold increase in interferon-gamma at 39 C
32:20 - 1929 Nobel prize - malaria infecting to cure neurosyphilis
1928 introduction of penicillin overshadowed this work
35:30 - strategies for home treatment if patient sent home by hospital
37:30 - ventilation more important than wiping down surfaces - probably not a huge vector
(Note: this is what has been apparent from the start - that aerosol/breathing/coughs/sneeze are the vector and conditions like stagnant room air - surfaces ie "fomites" are not going to be huge factor because virus dies and because touching your nose is not the same level of viral inoculum as sending viral particles or droplets into your nasal cavity or lungs for an extended period when sitting in room with stagnant air with others - however washing hands has been convenient proxy for that for soap sellers - but may indirectly have benefited for raising overall awareness)
Video and it's description section:
https://www.youtube.com/watch?v=vN30emwcNS4 If You Get COVID 19: Optimize Immune System (Vitamin D, Monoclonal Antibodies, NAC, Quercetin etc.)
Jan 3, 2021
Medcram
Professor Roger Seheult, MD gives practical strategies if you test positive for COVID-19 (or are in contact with someone who tests positive) including:
0:00 Video Intro
1:11 Use of a pulse oximeter at home to monitor oxygen saturation and possible COVID pneumonia
3:02 How to choose a pulse oximeter
3:34 Tips for using a pulse oximeter
5:35 Who qualifies for monoclonal antibodies (bamlanivimab, casirivimab, and imdevimab from Lily and Regeneron), how they work, and how effective are they?
11:11 The varying level of data/study strength for different strategies
12:55 Vitamins that may boost immune function: Vitamin D, NAC, Vitamin C, Quercetin, Zinc, Vitamin K-2, Magnesium
18:27 The importance of adequate sleep (Melatonin discussed)
21:57 Core body temperature elevation (the data on hydrotherapy and sauna use)
35:11 Isolation strategies at home: ventilation, HEPA filtration, mask-wearing
37:32 Summary of strategies to consider if testing positive for COVID 19
Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com
He is an Associate Professor at the University of California, Riverside School of Medicine and Assistant Prof. at Loma Linda University School of Medicine
Dr. Seheult is Quadruple Board Certified: Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine
Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com
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