TrumpLyftAlles | 16 points
Front Line COVID-19 Critical Care Alliance (FLCCC) Invited to the National Institutes of Health (NIH) COVID-19 Treatment Guidelines Panel to Present Latest Data on Ivermectin (US 2021-01-06) Drs. Pierre Kory, Paul Marik and Andrew Hill presented the ivermectin research![-] TrumpLyftAlles | 1 points
Fringe is going mainstream, baby! 😁👍
Note the bolded last paragraph. :)
On January 6, 2021, Drs. Pierre Kory and Paul Marik, founding members of the Front Line COVID-19 Critical Care Alliance (FLCCC), appeared before the National Institutes of Health COVID-19 Treatment Guidelines Panel. The panel, which is in the process of reviewing the rapidly emerging data on the role of ivermectin in the prevention and treatment of COVID-19, invited Drs. Kory and Marik to present the latest data, along with Dr. Andrew Hill—a senior research fellow at the University of Liverpool, who was hired by UNITAID to provide research for the World Health Organization (WHO).
The NIH invited the FLCCC members and Dr. Hill to the panel to present the four months of data on ivermectin that has emerged since the NIH last issued its guidelines on August 27. During the meeting, the FLCCC and Dr. Hill pressed the NIH to reevaluate their recommendation for ivermectin.
The doctors explained to the panel that numerous clinical studies—including peer-reviewed randomized controlled trials—showed large magnitude benefits of ivermectin in prophylaxis, early treatment and also in late-stage disease. Taken together, the doctors reported that the dozens of clinical trials that have now emerged from around the world are substantial enough to reliably assess clinical efficacy.
Specifically, the FLCCC physicians and Dr. Hill presented data from 18 randomized controlled trials that included over 2,100 patients. The trial results demonstrated that ivermectin produces faster viral clearance, faster time to hospital discharge, faster time to clinical recovery, and a 75% reduction in mortality rates.
“In order to save thousands who will die while waiting for their turn to receive the vaccine, it is imperative that treatment guidelines issued by the NIH over four months ago be updated to reflect the strength of the data for ivermectin in prophylaxis, early treatment, and late-stage disease, ” said Dr. Kory, FLCCC president, following the hearing.
The NIH panel signaled their intention to consider the data and update their recommendation but did not give a date for their decision.
[-] Murky-Lengthiness | 2 points
Please help! How many if the 14 randomized studies so far are published and how many preprints? Need this info because they are attacking the studies saying none are peer reviewed nor published.
[-] TrumpLyftAlles | 1 points
Who is they? Just curious. Thanks for fighting the fight.
This site says there are 18 peer-reviewed studies.
https://c19ivermectin.com/
I think it will take some digging to figure out which of those are RCTs.
I don't think arguing with people is often constructive. Unless it's a huge audience like /r/coronavirus or one that could actually apply the information like /r/medicine, maybe the worthwhile thing to do is just give them the link?
[-] Murky-Lengthiness | 2 points
A lot of MD’s are fighting against Ivermectin in the US and Latin America while a lot are fighting for it. After seeing the meta analysis they’re last resort is lying that none if the RCT’s are not published.
[-] TrumpLyftAlles | 1 points
they’re last resort is lying
I understand their not knowing about the research -- but why would they lie about it? Mysterious.
[-] Murky-Lengthiness | 2 points
They provide emergency authorization for any patent drug with small studies showing benefit but no one will submit to the FDA a study with Ivermectin because there si no money to be made in a generic drug. The system is broken because it is driven by profits not for the health of people
[-] TrumpLyftAlles | 1 points
NIH should have funded a study in April or (at the latest) August.
[-] Murky-Lengthiness | 2 points
Indeed
[-] Murky-Lengthiness | 1 points
https://www.sciencedaily.com/releases/2019/01/190122084356.htm
So angry. I heard they aren't expected to act 'till February. I called the FDA's emergency number a couple weeks ago. Someone should find/call the NIH's. I point out that it's killing a few people a minute. Needlessly. Because of the misinformation they're putting out. I recorded the call too.
[-] TrumpLyftAlles | 2 points
I heard they aren't expected to act 'till February.
Where did you hear that? If there is an authoritative source, please post the link. That's discouraging.
Speed is crucial if ivermectin is going to make a significant difference in the death toll. There are something like 35,000 people in the hospital with covid. I don't really know, but I imagine if even a third of them were treated with ivermectin, there might be a problem with supply. I think there would be a huge problem if the federal government decided to distribute ivermectin prophylactically. It could invoke the Defense Production Act to force Merck to ramp up production. Organizing distribution of weekly or every-other-week doses for 100-200-??? Americans is a giant task that would take time.
I haven't seen any projections about when all Americans will be vaccinated. That's the window during which ivermectin could save 10s of 1000s of lives: now to when everyone has been vaccinated.
I'll look. I think I recall, but don't want to misstate.
Agree with you pretty fully. In fact, think I tweeted @VP to invoke the DPA for IVM not long ago, and why! (Don't expect him to see it, or care if he did, but I figured many folks would notice the tweet, and it might help some of 'em!) But I wonder how much IVM there is.
I'm NOT an expert in this, and have 0 industry expertise, but I have thought about it and had my eyes open: Around 4 billion doses have been made in around 10 years. Ramping up production of IVM is trivial vs vaccines, especially mab vaccines. If I could give an Indian pharma company (like Dr Reddy's) $X,000 today that they committed would go to boost their production capacity and give me $X,000 of ivermectin as soon as they had spare capacity? I would! I'd love to know how tight the stocks of it are. Annual production of IVM in '19 was likely far, far greater than that for HCQ or IVSM. I heard prices in South America were spiking, but I sensed it was more driven by profiteering, panic buying (like toilet paper), and such than a real shortage.
[-] jzero4242 | 2 points | Jan 08 2021 11:01:21
It seems things just get delayed and delayed.
While an expensive drug is approved quickly, even after one trial, which "could reduce fatality by 24%"
https://www.gov.uk/government/news/nhs-patients-to-receive-life-saving-covid-19-treatments-that-could-cut-hospital-time-by-10-days
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[-] TrumpLyftAlles | 1 points | Jan 08 2021 23:42:07
Those are impressive results!
Results from the government-funded REMAP-CAP clinical trial published today showed tocilizumab and sarilumab reduced the relative risk of death by 24%, when administered to patients within 24 hours of entering intensive care.
Most of the data came from when the drugs were administered in addition to a corticosteroid, such as dexamethasone – also discovered through government-backed research through the RECOVERY clinical trial – which is already provided as standard of care to the NHS.
Patients receiving these drugs, typically used to treat rheumatoid arthritis, left intensive care between 7 to 10 days earlier on average. The rollout of these treatments could therefore contribute significantly towards reducing pressures on hospitals over the coming weeks and months.
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