FoolsAndMoney | 13 points | Jan 06 2021 18:10:15

Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress

https://www.sciencedirect.com/science/article/abs/pii/S0006291X16317429

Highlights

Ivermectin is effective in glioblastoma cells in vitro and in vivo.

Ivermectin inhibits angiogenesis.

Ivermectin induces mitochondrial dysfunction and oxidative stress.

Ivermectin deactivates Akt/mTOR signaling pathway.

Regarding the last two Highlights, what would be the result of long term ivermectin use?

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[-] dogrescuersometimes | 3 points | Jan 07 2021 05:34:56

3rd is cell death energy and structure destruction

4th from wiki The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane.

this is fantastic news.

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[-] ibexrecurve | 3 points | Jan 07 2021 05:43:55

Without mTOR activation you're not going to be building much (or any) muscle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650960/

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