ibexrecurve | 13 points
Ivermectin, a potential anticancer drug derived from an antiparasitic drug (China 2020-09-21)https://www.sciencedirect.com/science/article/abs/pii/S1043661820315152?via%3Dihub
[-] Fun-Hall-1351 | 4 points
Kicking the poo out of covid as well.
🤯 This stuff is fricken Amazing! No wonder they want to shut it down.. Big Pharma would go out of business! 😆
[-] Haitchpeasauce | 2 points
This paper sheds some more light on the subject:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900471/
I have seen this study used to flag ivermectin as dangerous to cells. Contrary to this, it is potentially dangerous to some cancer cells, which is good.
Previous publications have demonstrated that IVM induced cytostatic autophagy by blocking the PAK1/AKT axis in breast cancer [10]. IVM inhibited angiogenesis, growth and survival of glioblastoma [11]. Meanwhile, IVM induced cell cycle arrest and apoptosis of HeLa cells [12]. These studies suggested that IVM could be a potential new agent for cancers.
Recently, AKT/mTOR pathway has been identified to play a crucial role in the progress of human cancers [26]. In malignancies, activity of the AKT/mTOR pathway can be augmented, because of the AKT/mTOR pathway together constituting one of the most prevalent classes of mutations in human tumors, which makes it an attractive target for cancer treatment [27]. The role of autophagy in cancer is complex, and this complexity is illustrated by autophagy promoting or suppressing tumorigenesis [28–30]. Therefore, inhibiting or forcing autophagic machinery would be useful in drug cancer treatment [31]. The role played by autophagy depends on the concentration and the type of cancer cells. To date, there is no literature reporting that IVM induces autophagy in glioma cells.
So basically many cancer cells increase in AKT/mTOR as part of their way of refusing to die. Blocking on PAK1/AKT axis could cause this to stop and trigger cell death in the cancer cells.
The blocking of PAK1 is of broader interest for COVID-19 and other inflammatory driven disease because this then downregulates inflammatory signalling via STAT3 which is considered a possible driver of severe COVID-19.
https://www.nature.com/articles/s41418-020-00633-7
It's interesting how inflammation and cancer are related in this way.
[-] ibexrecurve | 4 points | Jan 05 2021 01:08:51
Highlights
• Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells.
• Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.
• Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.
• The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.
• Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors.
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