TrumpLyftAlles | 14 points
Ivermectin failed the test to combat Covid, study concludes (Colombia 2020-12-30) Dr. Eduardo López finds no difference between ivermectin and placebo groups :([-] Kirbinator13 | 8 points
I’m still a believer in Ivermectin. I’m the only one in the family that was exposed at Christmas and didn’t get COVID. The difference between me and them; Bimectin.
[-] Main_Performer4701 | 1 points
Do you think it was your pre or post prophylaxis dose that protected you? How soon is it effective?
[-] Kirbinator13 | 2 points
I was exposed on Dec 24th and didn’t take horse paste until the 31st. The person that I came into contact with didn’t show any major symptoms until Dec 28th, and had a confirmed positive test on the 29th. All that to say, I haven’t had a fever, severe cough, loss of smell/taste. Now could it be that the horse paste worked or I’m one of the lucky ones that are virtually unaffected by COVID? Nobody knows, but I will be taking horse paste every other week until this pandemic is over. I am not a doctor telling you to do this too, just saying I survived eating medication for horses and do not have COVID. Also, I am not on any other medications.
[-] Main_Performer4701 | 2 points
Nice. I take the horse paste every week and so far so good. Waiting on my tablets to come in.
[-] iamZacharias | 1 points
how do you get it? is the animal intended product all that safe?
[-] Main_Performer4701 | 1 points
Buy the paste from Amazon or any farm supplier. It’s safe as long as you ensure ivermectin is the only proprietary ingredient
[-] Haitchpeasauce | 4 points
This study is for mild disease only, at up to 7 days of symptoms, excludes people who used ivermectin within the last 5 days (originally 48 hours. How many in the placebo arm had taken ivermectin recently?). The design may not be able to demonstrate a difference if the placebo arm is recovering as well. The good news is it seems nobody died.
Link to further discussion: https://mobile.twitter.com/Covid19Crusher/status/1344649048880541696
The design may not be able to demonstrate a difference if the placebo arm is recovering as well. The good news is it seems nobody died.
The closest trial I could think of is the one from Bangladesh finished in October:
Inclusion Criteria:
COVID-19 infection, confirmed by polymerase chain reaction (PCR) test within 3 days from enrollment
Only mild and moderate COVID-19 infected cases
183 IVM + Doxy vs. 180 Placebo
There is a comparable secondary outcome: Number of Patients Having Clinical Deterioration
8.7% in IVM arm vs. 17.8% in Placebo arm
Compare these numbers against the Colombia hospitalization rate outcomes:
2% in IVM arm vs. 3% in Placebo arm
The Bangladesh 17.8% controls having deteriorated looks realistic.
The Colombia 3% controls having been hospitalized doesn't seem realistic even though the group consists of only mild cases.
I don't know, the placebo patients seemed to do very well against the odds.
What dose did they give the patients? Google translate says 1,5/2 drops per kg.
That could be anything depending on the concentration.
[-] TrumpLyftAlles | 2 points
From ClinicalTrials:
Ivermectin, 300 micrograms / kg, once daily for 5 days
Nice big dose.
It's coffee. Colombia is the capital of strong coffee. If they are serving coffee, it is hard to beat covid while drinking coffee. If they are anything like doninicans, then they are coffee addicts.
[-] fabionakaa | 3 points
That's nonsensical, all of Latin America drink coffee in huge amounts, including where ivm studies were successful.
Considering most of the IVM studies were hospitalized patients, this one was not, it makes perfect sense. While I can't speak for all hospitals in those countries, they don't serve coffee in hospitals here in Dom Rep.
Unless you have visited all countries listed in IVM studies and know their culture, the way they prepare their coffee, I can assure you, that is a wild card. For example the coffee in the states is so mild compared to the liquid cocaine they serve here, that it may take 2 or 3 cups.
Take Bangladesh for this example.
Coffee: a lifestyle or just another alternative to tea? | The Daily Star
Dec 29, 2019 — However, in Bangladesh, people go to coffee shops not only to drink coffee but as a source of entertainment. ... It does appear however, that as a nation Bangladesh will remain pre-tea for the near future, consuming and producing more tea than coffee.
On a side note, strangely, the hospitalized rate in this study was extremely low and I was trying to find out if they had any restrictions.
On another side note, one I am SO ANGRY ABOUT, there is this document floating around on what's ap, saying CNN latin america states that to drink coffee as it helps fight covid. People propagating that are getting people killed. Search for it on CNN latin america twice and no such report was made.
Wifes uncle, the dummy, fell for that propaganda after we told him several times, was making large leap in recovery on Lysine and IVM, on day 3 after starting that protocol, starting drinking coffee again, got worse quickly. He stayed sick for over a month, not gravelly ill, but none the less.
I am not anti-coffee, and I miss it terribly, but just a matter of fact, coffee will make most people with covid worse and extend recovery time. There is a small % of people who have the most incredible immune system that will recover none the less.
[-] fabionakaa | 1 points
I'm talking about the successful prophylactics studies and the early treatment ones. Brazil, Argentina, Peru and so on. All massive coffee drinkers.
My only failures on lysine prophylaxis were coffee drinkers or under dosed for weight. More than 100 used it.
Lets put it this way. My wife, 135lb, no symptoms, negative antibody test months later. We had sex a few times when I had covid. She was on 1000mg of lysine, no coffee.
Mother in law, she did drink a very small cup of coffee per day, lisinopril and 1000mg lysine, small NYC apartment, two confirmed infected, no isolation possible. Never a symptom for her, tested negative for antibodies 2 months later. 5 months later, kept drinking coffee with lysine and lisinopril, she did finally get a fever for 7 days, she had to go up to 3000mg per day to control the fever. Other than that she did great for all her comorbidities. Awaiting to check her antibodies.
Then there is this. https://www.researchgate.net/publication/345916326_Amino_Acid_L-Lysine_SARS-CoV-2_COVID-19_Prophylaxis
I know of 3 people who were on IVM prophylaxis, did get the virus, tested positive, 2 were coffee drinkers. Other was a long dist runner. Neither of the 3 did have a serious illness thankfully. They were on a fairly higher dose of ivm for prophylaxis.
[-] jackle0001 | 1 points
Can you expand on this? How is coffea a negative for people battling covid while taking ivermectin?
While on day 8 of covid, wife was bored, made a strong cup of Dominican coffee. Prior to the cup, I had near full symptom suppression using lysine. Within 2 hours my breathing shallowed and labored and I was considering going to check myself in to the hospital. I threw the kitchen sink at it, with multiple supplements, meds, old tricks, and within hour 4 or so, I got it somewhat under control, and went to sleep.
Woke up next day like nothing happened and wife asks me if I want a cup, remembering that wild 3 hours, I connected the dots. Said no.
About 40 hours after no symptoms and no lysine, feeling completely fine, experimented with a coffee. 1 hour after, symptoms returned, by 1.5 hours I chickened out and started back on lysine as the symptoms got much worse. By 2 hours I took another 1000mg of lysine, 20 min later symptoms plateu and started to drop. 2 weeks later repeated the experiment, 3 hours after a coffee, sore throat and little bit of a temp. Back on lysine and got it under control again.
To understand the most likely reasons that this happened you need to understand how lysine works by displacing arginine from the cell, inhibiting viral replication.
Search coffee arginine or caffeine arginine, you find a study that says caffeine inhibits normal consumption of arginine, forcing excess arginine into metabolic pathways.
This action is now displacing the lysine and supercharging arginine viral replication.
Next probable reason and probably more important than the first. Caffeine raises nitric oxide.
So you read this paper on NO role in inflammatory conditions and you understand why such a reaction can be had. https://pubmed.ncbi.nlm.nih.gov/18236016/#:~:text=Nitric%20oxide%20(NO)%20is%20a,over%20production%20in%20abnormal%20situations.
Lysine inhibits nitric oxide, specifically the trouble maker called iNos. That is like the horn of war signaling immune over reaction. Caffeine in essense inhibiting lysine, raises NO and have a terrible over reaction of immune system.
There is a few more minor reasons as well.
It is irregardless of ivermectin, although I did use some ivermectin in april. I know more than a few who were drinking coffee and using IVM, and they complained that IVM doesn't work. Until they quit the coffee, it is not powerful enough to overcome the supercharging or the virus.
[-] jackle0001 | 1 points
[-] Masculineenergy1 | 2 points
Hold up why is a failed study disappointing when ivermectin is clearly helping people
Because it will not help to broaden the acceptance of IVM
[-] Masculineenergy1 | 2 points
[-] Ok-Film-9049 | 2 points
Read Twitter comments. Someone said J&J sponsored so conflicts of interest. The other thing to note. This isn't ebola. Many people will get better with no treatment. If you pick the mild patients it will be very difficult to show a statistical difference in outcomes. I havent read the detailed report.
Exactly. Who cares about mild symptomatic patients? The only things that matter is how effective it is as a prophylactic and how well it treats patients with severe symptoms or hospitalized patients. The trials I have read support that it is effective and the differences between treated and untreated groups is statistically significant.
[-] Ok-Film-9049 | 1 points
Or at least select the high risk patients early in the course of the disease.
[-] Look_deeply | 1 points
The El Pais article notes (Google auto translation): “López explained that although this study was not reviewing whether the use of ivermectin helps reduce hospitalization of patients with covid, given that there was not a large or representative sample of participants, it was found that 3% of the people who received the placebo required to be hospitalized, while 2% of those who were given the antiparasitic had to be treated in health centers for complications of the disease.” Is there a difference between hospitals and health centers in Colombia? If so, would those treated in the latter tend to be less seriously ill?
[-] my-tech-reddit-acct | 2 points
given that there was not a large or representative sample of participants,
So, this might be an effect that Harvey Risch called out for some of the HCQ RCTs: if you don't use at-risk participants, it's hard to tell the difference. Most people do fine with Covid.
[-] i-am-pooping-rn | 1 points
There is no data published about this study...
[-] dogrescuersometimes | 1 points
Ok and how many mg in a drop? Maybe the dose was wrong? Maybe they didn't take it with fat?
The results of a study on Ivermectin in Cali were known, which answered the question of whether the drug cut or decreased the number of days that people had symptoms related to covid-19, and the great conclusion was that it does not have that incidence.
“In this case there was no difference between the people who received the placebo or the Ivermectin. So there was no statistical or clinically significant utility ”, assured Eduardo López, scientific director of the Pediatric infectious disease center, where the experiment was carried out.
It may interest you: Cali will have a total dry law from December 31 to January 2
The scientist added that based on the results of the study, they cannot recommend the widespread or massive use of Ivermectin for the treatment of COVID-19.
The research was carried out with around 400 people, with a confirmed diagnosis of covid-19 who had symptoms in the first seven days of the disease, in addition to an ailment that was still mild.
According to the scientist, they received 1.5 to two oral drops of the drug, by weight in kilos, for five consecutive days.
Half of the participants would have received the same doses but the placebo. The result of the study came after it was known that in in vitro studies, carried out in the United States, Ivermectin approved by the Food and Drug Administration (FDA), for other indications, seems to have an antiviral effect.
"In this scenario, the doses that were used were much higher, since they could not be reached in humans and they did show that the virus was inhibited enough, but they are concentrations that cannot be achieved in the lung or in the blood of the people, ”López said.
It may interest you: Cali carried out the first mock vaccination against Covid
The scientist does not rule out that other studies show favorable results for the drug Ivermectin with other variables, doses and routes of administration.
Source Integrated Information System
[-] Murky-Lengthiness | 1 points
3% hospitalization rate in a country with 3.4% mortality? Something is not right.
[-] Juanmacortes | 1 points
The mayor of Cali, the city in which the study was run, its a physician, he as a Mayor was recommending the city to take invermectin after reading the effects on several short studies. All the scientific community of Colombia started to criticize him for that. This its a news site, not a serious scientific portal. Eventhoug, at the end of the report, the dr. Says that if the dosis could be higher, the benefits of putting invermectin into the patient's blood and long system will be effective. At this moment, you could get a 5ml of ivermectin for U$2 and with no medical prescription here in Colombia
[-] Masculineenergy1 | 17 points | Jan 04 2021 08:40:12
I'm a 25 year old former athlete longhauler of 8 months and am suprised to be alive after fighting covid for as long as I did. Ive never had any health struggles before this and this thing almost took my life on multiple occasions. The day after I took ivermectin something unbelievable happened. I felt like I was in a new body. I felt better than I had in the last year. I could eat the foods that i wanted and as much as i wanted without the nasty inflammation attacks afterwards. I tried every remedy in the book and nothing worked even a quarter as well. IVM in my eyes is a miracle.
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[-] gaffney862 | 2 points | Jan 04 2021 21:21:49
What about your other long covid symptoms? Did those go away as well?
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[-] _UsUrPeR_ | 1 points | Jan 05 2021 02:38:17
Out of curiosity, what's your blood type?
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