Ivermectin and Fatty Liver Disease

[-] bikes4paul | 3 points | Dec 23 2020 05:11:31

I just advocated for a friend who was symptomatic with C19. He is prediabetic and has grade 1 fatty liver disease. His doctor felt there were no concerns with Ivermectin. He took the 200mcg/kg dose and was fine. His symptoms improved significantly the next day and have continued to improve. Just as a little piece of mind.

[-] TrumpLyftAlles | 2 points | Dec 23 2020 07:02:16

You're a good friend, and your friend has a good doctor. Glad to hear your friend is better.

Is the MD a primary care physician or general practitioner, or does he have special expertise with the liver? Either way, it seems reassuring for OP.

[-] bikes4paul | 2 points | Dec 23 2020 18:22:05

Thanks for the kind words. I provided the link of doctors who are willing to treat that's been widely shared on this sub and elsewhere. He has a good relationship with him PCP so that's who he went to with the I-MASK+ and FLCCC's Summary of Evidence in hand. His PCP agreed to treat with Ivermectin to his credit. Unfortunately, he dosed only at the typical antiparasitic dosing of 200mcg/kg (single dose). My friend did have a significant improvement in symptoms. However, it's now been 5 days and his progress has plateaued or possibly even declined a bit today. I told him to contact his PCP again today and request a second dose. I told him to emphasize the severity of his symptoms and tell him how much improvement he felt the day after the first dose. This friend is not comfortable with the vet option. I've let him know there are other doctors that will treat if his PCP refuses. We'll reach out to Dr. Hazan in Ventura if needed.

[-] TrumpLyftAlles | 2 points | Dec 23 2020 23:24:10

We'll reach out to Dr. Hazan in Ventura if needed.

I didn't know that Dr. Hazan was an option? I wasn't kind to her in my posts about the Borody trial going from N=300 to N=30. Maybe I should delete it; it's just whining anyway.

I'm forgetting the details: Does Mask+ or the FLCCC protocol mention a second dose after a week? I'm vaguely recalling that. Your friend's MD might be willing to do a second dose if he sees that recommended in a protocol. Let me know if you can't dig it up and I'll look.

[-] bikes4paul | 3 points | Dec 24 2020 00:53:15

I haven't used her yet for any of the patients I've assisted. I know she provided HCQ to Dr. McCullough and I know she's treating patients with IVM. She's a strong believer in IVM and is running the small trial with Dr. Borody. She's also very independant minded and won't stand for the NIH Guidelines trying to tie her hands. Unfortunately, her RCT is self funded and not progressing rapidly as a result. It's so damn frustrating that the NIH threw $223 million of our taxpayer $'s for the worthless Remdesivir RCT but nothing for safe promising repurposable drugs. Dr. Rajter's been trying to obtain funding for his proposed RCT for months and still nothing. Anyway, I do think Dr. Hazan is a good resource. I might have first hand knowledge soon if my friend needs more IVM (I think he does). If so, I'll post my results.

[-] TrumpLyftAlles | 2 points | Dec 24 2020 00:59:11

It's so damn frustrating that the NIH threw $223 million of our taxpayer $'s for the worthless Remdesivir RCT but nothing for safe promising repurposable drugs. Dr. Rajter's been trying to obtain funding for his proposed RCT for months and still nothing.

That IS really frustrating. Argh. Argh-and-a-half.

I don't understand why trials are so expensive. Cut some corners, like use the $30 test for the virus that the FDA recently approved. Add ivermectin to the standard of care for a random half of the patients: 600mcg/kg on days 1 and 7 is less than $100. Wait, for patients treated in the hospital, their insurance will cover that. I wish I knew more about how trials are done. I don't get where all the money goes.

The Gates Foundation is paying for Medincell's ivermectin research. Why can't they drop a couple million for US ivermectin trials?

I might have first hand knowledge soon if my friend needs more IVM (I think he does). If so, I'll post my results.

Thanks!

[-] bikes4paul | 2 points | Jan 09 2021 23:04:18

I now have first hand knowledge of Dr. Hazan's trial. I have another friend that needed IVM. 7 days post sx onset and started having SOB. After a doctor on the widely circulated list said they would charge $125 and $250 for the meds and they wouldn't take insurance. She didn't have it since she's been out of work due to the pandemic. She contacted me again so I advised her to call Dr. Hazan to see if she qualifies for their RCT. She did and the entire kit is free. They drove the kit to my friend from Ventura to Riverside (2.5hrs). The kit includes IVM, Doxy, zinc, Vit D, Vit C, stool sample collection containers, pulse oximeter, and Holter monitor. I'm very impressed!

[-] TrumpLyftAlles | 1 points | Jan 09 2021 23:07:42

They drove the kit to my friend from Ventura to Riverside (2.5hrs). The kit includes IVM, Doxy, zinc, Vit D, Vit C, stool sample collection containers, pulse oximeter, and Holter monitor. I'm very impressed!

That's AMAZING. It's an opportunity with a small window, with N=30 (so only 15 people will get ivermectin). But you can't ask for better service! Wow!

Could you please post this to /r/gettingIvermectin and include Dr. Hazan's phone number?

[-] bikes4paul | 2 points | Jan 10 2021 21:15:05

Posted: https://www.reddit.com/r/gettingIvermectin/comments/kun5v0/progenabiome_ivermectin_rct_experience/

[-] TrumpLyftAlles | 1 points | Jan 10 2021 21:32:49

Thanks!

[-] ilovekitty1 | 2 points | Dec 22 2020 15:52:16

Your post says that ‘the manufacturer does not recommend that treatment be excluded..’ This means that they are not saying not to take it.

[-] TrumpLyftAlles | 1 points | Dec 22 2020 23:17:32

Right! Merck would know if it's a problem! :)

[-] Impressive_Run8581 | 2 points | Dec 24 2020 22:49:02

There is a lengthy and active discussion on Ivermectin MD Team for these exact same reasons. I tried to post it but there is a 10k limit for reddit.

Key points

Some important details about IVM.MetabolismPrimarily hepatic. Ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1 % of the administered dose excreted in the urine .Route of elimination Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine.Some proposed alternative strategies for minimal use of IVM and reduction of toxicity risks.The idea behind this is you don’t want the cure to be worse than the disease. If you have very low risk and exposure, it isn’t necessary to subject yourself to the risks of continuous and high IVM use when minimal sporadic use will protect you equally as well.NB - These are not criticisms of any of the other well researched or established protocols for continual prophy use of IMM. These are merely alternative protocols for those that may have previous organ and toxicity concerns and can accurately assess and manage their risks profile.If you already have liver issues including NAFLD or have ever heard the term ‘fatty liver’ described by your MD after lab tests, you should assess your risks and modify them as well as conduct regular liver panel labs.Baseline protection: I-MASK+ Prophy Protocol v6 https://covid19criticalcare.com/.../i-mask-protocol.../ excluding continual IVM use.Strategy for low risk, exposure and contact: Take 3mg IVM 6-12 hours before expected exposure, add in additional zinc, quercetin, and C, use carrageenan spray immediately before exposure and avoid food and liquids until after exposure. Use tight fitting N95 mask and common-sense safety measures. Wash exposed clothing and shower post exposure.Strategy for medium risk, exposure and contact: Same as above but continual use of IVM at the rate of 3mg every 3 days.Strategy for high risk, exposure and contact: Same as above but continual use of IVM at the rate of 4.5mg IVM every 3 days.Strategy for those using continual IVM: Have a complete liver panel run every 3 months and if there are issues, reduce or cease IVM use and recheck panels in 30 days. Alternatively, if using one of the rancher solutions switch to ivermectin tablets to isolate the suspension materials used in the 1% and 1.87% solutions.

Alanine transaminase (ALT). ALT is an enzyme found in the liver that helps convert proteins into energy for the liver cells. When the liver is damaged, ALT is released into the bloodstream and levels increase.
Aspartate transaminase (AST). AST is an enzyme that helps metabolize amino acids. Like ALT, AST is normally present in blood at low levels. An increase in AST levels may indicate liver damage, disease or muscle damage.
Alkaline phosphatase (ALP). ALP is an enzyme found in the liver and bone and is important for breaking down proteins. Higher-than-normal levels of ALP may indicate liver damage or disease, such as a blocked bile duct, or certain bone diseases.
Albumin and total protein. Albumin is one of several proteins made in the liver. Your body needs these proteins to fight infections and to perform other functions. Lower-than-normal levels of albumin and total protein may indicate liver damage or disease.
Bilirubin. Bilirubin is a substance produced during the normal breakdown of red blood cells. Bilirubin passes through the liver and is excreted in stool. Elevated levels of bilirubin (jaundice) might indicate liver damage or disease or certain types of anemia.

[-] mesham31 | 1 points | Dec 26 2020 14:49:18

thank you.

[-] WisdomTooth0 | 1 points | Mar 03 2021 07:31:32

Alternatively, if using one of the rancher solutions switch to ivermectin tablets to isolate the suspension materials used in the 1% and 1.87% solutions.

Is the "rancher solution" the horse paste? What "suspension materials"?

[-] Impressive_Run8581 | 2 points | Dec 24 2020 22:53:00

Other reports I've seen for acute use indicate that lOOR liver panels will resolve back in range after use of IVM. The best protocol IMHO is run baseline panels and if in range, then take the IVM and follow up with more panels.