roonie1 | 6 points
Ivermectin dosingI don't understand the prophylaxis dosing recommended in the FLCCC I-MASK + protocol:
"One dose on Day 1 and Day 4 then every 4 weeks. "
Huh? The half life can't be 3 weeks long. How does this make sense? I'd think dosing twice a week would make sense.
https://covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-I-MASK-Protocol-v5-2020-11-28.pdf
[-] TrumpLyftAlles | 4 points
Ivermectin persists in the tissues. I don't really understand what that means, but it's supposed to imply that the 18-hour half-life in the blood stream isn't relevant.
I don't believe it. Based on the 18-hour half-life, I'm dosing twice a week for prophylaxis.
I'm often wrong, though.
[-] smorgasmic | 1 points
I think we interacted in another thread and I pointed you to a comment I made there. I will repeat in short form here.
Ivermectin's mechanism of action is to interfere with an important biological function of your cells. It downregulates the ability to take proteins from the cytoplasm into the nucleus. Since some viruses use that pathway, it therefore stops the viral replication. But the virus isn't the only thing that needs that pathway. Your cells need it too!! The prophylactic dosing is intended to give a short period where viral replication is lowered, but then they stop taking ivermectin to allow your cells to recover.
My opinion is that leaving ivermectin in your plasma around the clock - week after week - might be incredibly dangerous.
[-] TrumpLyftAlles | 2 points
I take your point. If in fact ivermectin blocks imp alpha/beta1, and that import method is there for a reason, then there should be things going wrong.
On the other hand, 788 health workers in the Argentine study took IVM for 3 months without observing issues. OR they weren't reported, anyway. I've been dosing twice a week since May and feel fine. Dr. Aguirre, whom I trust implicitly, doesn't recommend days off, and approves occasional twice-a-week dosing:
Taking it weekly you get a prophylaxis of 99% on average. If it is a person who does not go frequently to places of high risk of exposure, we see that it reaches 100% by taking it weekly. In the highly exposed, you could go up to 2 weekly doses, on the 1st and 4th of the week.
On the other hands, there's covid. I'm high risk 5 ways. Let's see if I can think of them all: old, fat, diabetic, hypertensive, blood type A. Prophylaxis with ivermectin might not be worth the unknown downside if you're 30 years old, or even 50 years old without comorbidities.
IMO, obviously, it's worth the risk for me.
THANKS for persisting! You're doing it out of concern. That nice!
[-] Fun-Hall-1351 | 2 points
If you are a man-6 reasons to dose weekly with IVM.
[-] TrumpLyftAlles | 2 points
You're right! 6! I didn't remember that one. LOL.
[-] JosephTheManJohnson | 1 points
It seems most people use the horse paste--I'm wondering if you have ever tried the 1% Ivermectin injection version taken orally?
[-] TrumpLyftAlles | 1 points
I have not. I have some of the 1% solution but I also have a ton of horse paste, and taking it takes literally 20 seconds by this time, so why switch?
If I ever get my act together, I'll try using the 1% solution with a nebulizer.
[-] Haitchpeasauce | 3 points
Dr Kory explains his reasoning in one of his videos which I don't have on hand, but is basically as follows:
Ivermectin has a long half life in tissues, which is why giving it as heartworm medication to dogs is once per month. Due to this drug being repurposed and therefore approached with caution by the public, FLCCC has compromised and given a guideline that is easier to accept and more affordable while (in their estimation) giving adequate protection. The truth is there is no data about length of prophylactic efficacy against COVID-19 for a single dose. So rather than weekly dosage which some might perceive as too onerous, they opted for a loading dose followed by monthly. This isn't perfect but will still have an impact.
Dr Kory is not suggesting that more frequent prophylactic dosing is either hazardous nor excessive, their proposed protocol is a balance between efficacy and ease of adoption/compliance.
[-] Fun-Hall-1351 | 2 points
Most medical Drs overseas are taking a dose once a week.
Taking it once a month seems odd to me also. My Drs script is 6ea 3mg pills once a week. I weigh about 195lbs. I also read about taking them after a fatty meal to make for better absorption. Dr was ok with that too. Do remember--the dosing for AVM in my box was for parasites--which you probably need to take on an empty stomach.
Thank you.
Any medical type reference for that? It makes more sense to me than once a month.
BUT, if there is data that once/month is effective,...less meds by all means!
[-] Fun-Hall-1351 | 2 points
Omg yes. Start with Drbeen on YouTube.
[-] Fun-Hall-1351 | 2 points
https://c19protocols.com/?fbclid=IwAR3ZN2Y5mvZrBLIEO5PYRUbNUoJKyTPTY6iq1ndbw2ltEzXCTN4FN_2G8Sk.
Plenty of research studies here.
[-] apollo11junkie | 1 points
Kind of a side question: Do you know of a recommended conversion from 1.87% paste?
Convert body weight to kg. (Eg. 170 lbs = 77 kg) Say desired dose is 200 mcg/kg body weight; 77 * 0.000200 = 0.0154 g or 15.4 mg ivermectin. Divide by gel concentrate. 15.4 / 0.0187 = 824 mg gel or 0.824 g of gel which you can weigh out on a $10 0.1g digital scale (0.8 or 0.9g)
I’m pretty sure that’s the correct calculation. Let me know if I made a mistake.
[-] apollo11junkie | 1 points
Sounds good. I don't know the industry but the arithmetic looks good to me. Is 0.0187 a constant, or have a unit of measure?
[-] thismyusername69 | 1 points
So If i'm 260lbs and have the 1.87% paste, how much am I taking? lol
Hi. The reply given above is an example of how you would calculate the amount of IVM 1.87% gel to take if you want a 200 mcg/kg dose. I'm pretty sure the calculation is accurate. I'm hesitant, however, to give a specific dose for an individual since this is (possibly harmful) pharmaceuticals were talking about.
If you are unclear about how dosing conversions are done, please be very cautious in taking medical advise over the internet! Find someone you trust (in real life) to explain it to you if at all possible.
Good luck.
[-] converter-bot | 0 points
170 lbs is 77.18 kg
in their press conference they mentioned that rationale for every 1 month was because thats what you give for dogs for heart worm, however, when you google that it says it doesnt kill the heart worm for a long time and it could take a year, so thats really not a good rationale for monthly ivermectin, since covid acts so fast and in between ivermectin doses you might get it and progress to bad covid, so personally, on the assumption that ivermectin does offer some protection, so I'm going to take it more often than once monthly. probably weekly or every 10 days sounds better, to me.
Actually, from my understanding. The Ivermec kills the larvae stage of heart worm before it enters the worm stage. It will also kill the adult worms but the objective is killing the larvae. The larvae have 3 months in this stage, hence the reason you can dose once a month, there is a large window of opportunity. Ivermectin is also used off label drug for démodex. In order to work, it was given daily as the drug doesn’t have a long enough effect to take out demodex mites. So I feel that once a week is better insurance for a virus that arrives ready to replicate.
[-] TrumpLyftAlles | 3 points
Ivermectin is also used off label drug for démodex.
I've been taking the horse paste since May. An unexpected side-effect is remission of CHRONIC ITCHING that has plagued me for literal decades, that 3 dermatologists couldn't help me with, that was bad enough to interfere with sleep 1-2 nights/week. GONE.
[-] smorgasmic | 1 points
The dose for demodex mites is daily for how many days?
https://pubmed.ncbi.nlm.nih.gov/7591924/
[-] TrumpLyftAlles | 1 points
Procedure: All dogs were treated with undiluted ivermectin at a dosage of 0.6 mg/kg of body weight, PO, every 24 hours. There was no other parasiticidal agent given topically or systemically. A physical examination and multiple skin scrapings were performed every 2 to 4 weeks while dogs were receiving ivermectin. Skin scrapings were performed at approximately the same sites at every examination. After no mites were seen, treatment was continued for at least 2 more weeks and then stopped. Dogs were reexamined, and skin scrapings were repeated if any skin lesions developed. For dogs that remained clinically normal, follow-up information was obtained by telephone. Dogs that were free of clinical signs of demodicosis 12 months after ivermectin administration was discontinued were considered cured.
Results: Ten of 12 dogs were cured. Median duration of treatment for these dogs was 10 weeks (range, 6 weeks to 5 months). Two dogs were failures, relapsing 10 months and 11.5 months after treatment was stopped. One of these dogs was successfully treated with a second course of ivermectin. Mild ivermectin toxicosis developed in 1 dog after 6 weeks of treatment; side effects resolved shortly after the treatment was stopped.
Clinical implications: Daily use of ivermectin, at a dosage of 0. 6 mg/kg, PO, was found to be effective in the treatment of generalized demodicosis in dogs.
[-] Excellent-Garden1718 | 1 points
Dr. Been replied to a similar question on a recent video. He indicated that he preferred smaller dose more often. I don't remember which video it was in. Anyone know?
[-] Excellent-Garden1718 | 2 points
Replying to myself. I found the video where he discusses it. I linked it at the beginning of that question https://youtu.be/17_U4RPOvqE?t=1413
[-] TrumpLyftAlles | 1 points
Thanks for queueing it up to the relevant part!
Roughly:
I look at the ivermectin half-life, which is about 18 hours. I usually give 150mcg/kg, and to me, it should be taken every 3 days. At least twice on days 1 and 4, then the same every month. This is my safe prescribe. When I'm more worried, I give them 12mg ivermectin every week. This is what my own family members are doing.
That pretty much covers the gamut. LOL.
I'm with Dr. Been, dosing twice a week (easier for me to remember than every 3 days -- I have Alexa remind me).
[-] PepeLePewwwww | 8 points | Dec 10 2020 03:24:54
Folks, Dr. Pierre Kory here. Please see updated protocol, www.flccc.net, we converted to weekly dosing prophylactically as per recent carvallo study, we are evolving and learning along with you.
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[-] roonie1 | 1 points | Dec 14 2020 18:51:28
Thank you Pepel !
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[-] OperationRich | 1 points | Dec 15 2020 01:44:54
https://c19protocols.com/?fbclid=IwAR3ZN2Y5mvZrBLIEO5PYRUbNUoJKyTPTY6iq1ndbw2ltEzXCTN4FN_2G8Sk
Thanks so much! I was curious, would a doctor RX this medication with someone who's kidney function is only 16% and who has liver disease? My mother cannot catch Covid, and I think I could get her an RX for this medication, if the doctor felt it wouldn't cause more harm. Thanks!
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