The analysis shows that the safety profile and adverse effects of ivermectin was not dose-dependent. In other words, the frequency and intensity of adverse effects was similar in groups receiving doses above or under 400 µg / kg. In one study, a small number of healthy volunteers received doses up to 2000 µg / kg (10 times the recommended dose). However, one trial did report transient ocular adverse events related with high doses of ivermectin in onchocerciasis patients, which can be of concern in this type of patients and is a call for caution.
“Although limited by the small number of studies, our review adds evidence to the safety of ivermectin at doses up to 800 µg/kg, ” concludes Krolewiecki. Further studies are needed to evaluate the safety of ivermectin at higher doses, particularly in children under 15 kg and in pregnant women.
[-] TrumpLyftAlles | 4 points | Oct 21 2020 08:42:59
This is an article about this study.
The analysis shows that the safety profile and adverse effects of ivermectin was not dose-dependent. In other words, the frequency and intensity of adverse effects was similar in groups receiving doses above or under 400 µg / kg. In one study, a small number of healthy volunteers received doses up to 2000 µg / kg (10 times the recommended dose). However, one trial did report transient ocular adverse events related with high doses of ivermectin in onchocerciasis patients, which can be of concern in this type of patients and is a call for caution.
“Although limited by the small number of studies, our review adds evidence to the safety of ivermectin at doses up to 800 µg/kg, ” concludes Krolewiecki. Further studies are needed to evaluate the safety of ivermectin at higher doses, particularly in children under 15 kg and in pregnant women.
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