From the paper: "nebulized ivermectin can reach pharmacodynamic concentrations in the lung tissue of rats, additional experiments are required to assess the safety of this formulation in larger animals". And "Ivermectin has shown in vitro and in vivo effects against other flaviviridae. How well the respective modes of action translate to SARS-CoV-2 is under investigation. Until we have more appropriate in vitro results for key steps such as viral entry via ACE2 receptors or nicotinic receptors, or viral replication, drug regimen design will be difficult.
[-] No_Entertainment_764 | 2 points | Oct 13 2020 17:57:11
Chaccour is the lead author.
From the paper: "nebulized ivermectin can reach pharmacodynamic concentrations in the lung tissue of rats, additional experiments are required to assess the safety of this formulation in larger animals". And "Ivermectin has shown in vitro and in vivo effects against other flaviviridae. How well the respective modes of action translate to SARS-CoV-2 is under investigation. Until we have more appropriate in vitro results for key steps such as viral entry via ACE2 receptors or nicotinic receptors, or viral replication, drug regimen design will be difficult.
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