Covid-19 Acute: Treatment with High Doses of Ivermectin in Moderate, Severe And Critical Cases. Table: Dose of Ivermectine According to Severity, Viral Load And Response to Treatment (Peru 2020-07) Dr. Aguirre
For the treatment of Acute COVID-19, it is better to resort to higher doses than the regular dose of 0.2 mg. used to treat ectoparasites. These higher doses are supported by the study published by Leon Caly et al., In which viral RNA was reduced by 99.8% in 48 hours (reduction of 5,000 times) using a very high dose, it is mentioned that it is 30 or more times the regular dose of 0.2 mg / kg. There is also the study by Cynthia Guzzo et al: "Safety, tolerability, and pharmacokinetics of escalating high doses of Ivermectin in healthy adult subjects" published in The Journal of Clinical Pharmacolgy in 2002, in which it demonstrated that IVM is well tolerated at doses of 1.0 and 1.5 mg/kg. doses, to which we are only resorting in Severe and Critical cases.
The main objective of giving sustained high doses is to reduce the viral load and replication in an early way and in this way prevent the disease from progressing to Severe and Critical cases. On the other hand, it also seeks to avoid Persistent Infection by the virus and the reactivation of symptoms. We have observed that, just as there is a Pre-Symptomatic stage, there is a Post-Symptomatic stage in which there is still a viral load but in low quantity so it practically does not produce symptoms, but the total elimination of the virus must be ensured, otherwise it can present days after the reactivation of symptoms. It is indicated then that the patient should continue treatment with IVM until after he does not present any symptoms (including episodes of fatigue, myalgia, chest pain, or other mild symptoms), at this stage the daily doses to be given are lower, of between 0.2 to 0.6 mg per day, this according to the severity of the case.
[-] TrumpLyftAlles | 3 points | Oct 03 2020 21:47:48
Dose per KG
Dose per pound
For the treatment of Acute COVID-19, it is better to resort to higher doses than the regular dose of 0.2 mg. used to treat ectoparasites. These higher doses are supported by the study published by Leon Caly et al., In which viral RNA was reduced by 99.8% in 48 hours (reduction of 5,000 times) using a very high dose, it is mentioned that it is 30 or more times the regular dose of 0.2 mg / kg. There is also the study by Cynthia Guzzo et al: "Safety, tolerability, and pharmacokinetics of escalating high doses of Ivermectin in healthy adult subjects" published in The Journal of Clinical Pharmacolgy in 2002, in which it demonstrated that IVM is well tolerated at doses of 1.0 and 1.5 mg/kg. doses, to which we are only resorting in Severe and Critical cases.
The main objective of giving sustained high doses is to reduce the viral load and replication in an early way and in this way prevent the disease from progressing to Severe and Critical cases. On the other hand, it also seeks to avoid Persistent Infection by the virus and the reactivation of symptoms. We have observed that, just as there is a Pre-Symptomatic stage, there is a Post-Symptomatic stage in which there is still a viral load but in low quantity so it practically does not produce symptoms, but the total elimination of the virus must be ensured, otherwise it can present days after the reactivation of symptoms. It is indicated then that the patient should continue treatment with IVM until after he does not present any symptoms (including episodes of fatigue, myalgia, chest pain, or other mild symptoms), at this stage the daily doses to be given are lower, of between 0.2 to 0.6 mg per day, this according to the severity of the case.
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