Ivermectin Could Turn COVID-19 Around. We Need To Find Out If It Works. (US 2020-10-01) TrialSiteNews Mary Beth Pfeiffer @marybethp

[-] jewelsn24 | 4 points | Oct 02 2020 05:42:06

We better tell President Trump and his wife who have just tested positive to Covid to use it.

[-] TrumpLyftAlles | 3 points | Oct 02 2020 06:49:38

It is rumored (this isn't a joke) that Trump uses ivermectin skin cream to treat rosacea. <- That is the first time I spelled that word correctly on the first try. LOL

He'll probably ingest some, in the spirit of his bleach suggestion to Dr. Birx, and ivermectin will save him! More LOL

[-] jewelsn24 | 3 points | Oct 02 2020 07:00:23

Yes you are right. I forgot about that. I do remember now that I heard Professor Thomas Borody mention that he uses Ivermectin topical ointment for his Rosacea. If he is still using it he will probably be fine. Interesting point.

[-] TrumpLyftAlles | 1 points | Oct 02 2020 07:33:42

If he is still using it he will probably be fine.

Seriously? You think topical ivermectin will penetrate the blood stream in sufficient amounts to have an effect? I would be amazed.

Lots of people in /r/rosacea use ivermectin. I wonder if we could learn anything by asking about their covid experience. Probably not.

[-] Ok-Film-9049 | 1 points | Oct 06 2020 14:38:24

After buying a boatload, i read that skin absorption was very poor, cue the vet stores

[-] TrumpLyftAlles | 3 points | Oct 02 2020 00:07:50

This is a well-researched article, that puts a human face on ivermectin: lives saved.

She quotes someone making the hated CONCENTRATION TOO HIGH!!! argument, but it's just one reference, late in the article. It's a lousy argument, based on an in vitro study (weak weak evidence) that used green monkey cells, which barely express ACE2. It's especially ridiculous given all the real-world success ivermectin is having.

One quibble with the article:

She cites this ivermectin trial, which reported no statistically-significant effects from ivermectin. WRONG. They computed their statistics incorrectly. The report includes the mean and standard deviation for several outcomes, but every p-value is "p.05", so I computed the p-values out of curiosity. Shortness of breath was statistically significant in three of the study's tables, fatigue in one.

Good stuff from Dr. Thompson, a Columbia, S.C. ER doc who I never heard of (the author found him on Facebook):

Nothing To Offer The Infected

With no approved early treatment, symptomatic patients are told to hydrate, take palliatives and quarantine. That works mostly for young, healthy bodies that spend lots of time in the sun. But a week into the infection, too many other patients show up in Dr. Charles Thompson’s emergency room in Columbia, S.C. These include patients with low Vitamin D levels – even young ones — or pre-existing conditions like diabetes, hypertension or cardiovascular disease. “They are clutching at their chest, gasping for breath and begging you to save them,” Thompson, a pulmonologist, told me. “I’m sick of watching people die this way. It’s a travesty.”

Why? Because it’s unnecessary. Since late February, Thompson has treated perhaps a thousand outpatients with hydroxychloroquine, azithromycin, zinc and supplements, to which, in May, he added ivermectin. Just one of his patients has been hospitalized — for COVID-related diarrhea. A voracious reader of the medical literature, Thompson is in awe of the “elegant” way that ivermectin functions, working, he and others have learned, both in early and later COVID stages.

While the virus is multiplying in early infection, ivermectin is believed to inhibit a key receptor that opens the door for viral proteins to enter the nucleus of cells and replicate. Later on, the drug may inhibit the virus from adhering to CD147 receptors on red blood cells and forming clumps, the process that can lead to dangerous clots and stroke. Thompson is among a dozen practitioners I have spoken with who believe that hydroxychloroquine has been maligned and miscast – it is effective and safe, they hold.

I'm not following HCQ. I thought it was premature when people concluded "case closed, HCQ doesn't work" -- but I don't want to get into that controversy.

[-] Z3rul | 2 points | Oct 02 2020 03:06:34

isn't the argentina high dosage study a good response to the CONCENTRATION TOO HIGH argument?

btw, i don't know what is going on with the papers/pre-print of that study, my contacts know nothing and there is no answer for anyone they all went radio silent after that study got done. it's weird

[-] TrumpLyftAlles | 1 points | Oct 02 2020 03:13:30

Hmm: Did I forget a trial? I don't remember an Argentina high dosage study -- or any dosage study that has reported results. I forget stuff.

There are a bunch of answers th CTH!!! Among them is: it's just an in vitro study. We don't proclaim ivermectin a proven effective for covid-19 because Monash found 99.98% of the virus killed. That would be dumb because everyone knows that the findings of in vitro studies are often not replicated by further research.

Yet a dozen articles make the argument that ivermectin won't work, based on an in vitro study. Bad science.

A better argument is the success we've seen with ivermectin in trials: 8/9 (or so) show positive effects.

[-] jewelsn24 | 2 points | Oct 02 2020 07:39:55

You are right probably right but Borody seemed to think it might help because it might accumulate in his body over some time. Probably way too low though.

[-] TrumpLyftAlles | 2 points | Oct 02 2020 08:25:20

It would be such an easy study: review the hospital EMR for patients who were prescribed ivermectin for rosacea or scabies, find out what percent were diagnosed covid+, compare that to the rate of covid+ among age-matched patients who didn't get ivermectin.

[-] usernaeim | 1 points | Oct 02 2020 06:51:08

It's october. Why are they so slow?

[-] scionkia | 2 points | Oct 02 2020 10:35:51

The longer Ivermectin trials are slow walked....each remsdesivir dose administered rings up $3k into the cash register. I hope this is not the case but it all looks fishy to me. The NIH still won’t even officially recommend vitamin d supplements.

[-] TrumpLyftAlles | 1 points | Oct 02 2020 06:56:45

Sorry, I don't understand the question?!

[-] usernaeim | 2 points | Oct 02 2020 07:05:47

I expected the results of the RCTs to be published sooner

[-] TrumpLyftAlles | 2 points | Oct 02 2020 07:32:04

Me too. I think some are delayed for wont of covid+ patients. The SAINT trial (Dr. Chaccour) was suppose to finish on August 30. Spain had a good summer though, low covid infections. Good news, in a weird way: covid is up in Spain and Dr. Chaccour is enrolling.

[-] Boring-Staff6569 | 2 points | Oct 02 2020 10:40:23

Professor Borody will make a pronouncement about Ivermectin in 10 days or so..apparently he has the ear of Australia's chief health officer

and trials on infected patients/staff are progressing.

https://www.triplem.com.au/shows/night-shift-with-luke-bona/catch-up/445dbecb-ae1d-4181-8582-ac44013722b5

hopefully the practitioner uptake doesn't take as long as the triple therapy for peptic ulcer infection,

[-] TrumpLyftAlles | 1 points | Oct 02 2020 11:32:37

Thanks for the update!

But I'm too lazy or something to listen to the interview or whatever it is. Can you please give me a TL;DR?

[-] Boring-Staff6569 | 2 points | Oct 02 2020 19:57:03

TL;DR

i 'm too lazy to find out whatTl,, DR means..

however Borody is persistent.. just as peptic ulcers and Chrohn's disease were/are.. I fully expect ivermectin to upset BigPharma's dreams.. its going well in the Philippines and Argentina..

The NIH needs to upgrade its treatment guidelines to the level of a third world country.. and abandon Remdesivir

"Professor Thomas Borody. Dr. Borody is my personal physician, and he saved my life. "

https://www.psychologytoday.com/au/blog/pura-vida/201312/i-am-not-boycotting-israel

[-] TrumpLyftAlles | 1 points | Oct 02 2020 23:43:16

Sorry for the confusing reddit-speak.

TL;DR stands for Too Long; Didn't Read.

It's a courtesy that a lot of posters provide at the bottom of long posts. It provides the gist of the post, for readers who don't want to slog through the whole thing. It's typically 1-3 sentences.

So I was asking for a brief summary of the audio.

Philippines? I'm aware of Dr. Hibberd's recent interview (couldn't muster the attention span to watch it all) but that's the only thing I'm aware of, from the Philippines. What's going on there?

I don't know much about Remdesivir. Why do you think it should be ditched?

I know nothing about NIH treatment guidelines.

What I don't know could fill a wikipedia. ;)

[-] Haitchpeasauce | 1 points | Oct 03 2020 04:42:47

Remdesivir is an antiviral administered via IV, hospital setting only. Very expensive, lots of side effects like renal failure and hear arrhythmia. By the time it's given (someone has to be very sick) it's likely the viral replication phase has passed. NIH has Remdesivir on its guidelines because an RCT was rushed through showing it reduced hospital stay length.

Its mechanism of action is interesting. The metabolite of the molecule is used in building RNA, but it's a faulty building block causing the viral RNA to not copy properly. As you might see, it's not as good as the way zinc (and maybe Ivermectin) blocks replication, or ivermectin's action of blocking coronavirus from sequestering importin a/b.