This safety study found that 10 times the FDA-approved 200mcg/kg (approved for the treatment of scabies) is safe, esp. there were no signs of Central Nervous System problems.

This clinical trial is the most extreme dosing that I've heard of: 1200mcg/kg per day for 5 consecutive days! I wrote code to figure out how high ivermectin would get in the blood with that dosing: max is 1974, just under the 2000mcg/day that the safety study deemed safe.

The upper-limit on ivermectin dosing is actually unknown, because no one has tested high enough doses to evince problems!

Are you in the US? In the US, off-label use is probably less of a liability issue if they stick with 200mcg/kg.

Doxycycline is a good idea!

This study is a bit confusing because it compared IVM + DOXY to HCQ + AZT, but IVM + DOXY showed good results.

In Uttar Pradesh (India's largest state, 204 million people) the government is endorsing IVM + DOXY.

In this not-yet-reported trial, they're trying:

Treatment: Ivermactin 6 mg 2 tab stat, cap (that's 200mcg/kg for ~65kg person, if memory serves)
Doxycycline 100 mg 1 cap BD 5 days

This study (recently published in a journal here) had good results.

The dose of ivermectin was 0.2 mg/kg single dose. Doxycycline 100 mg daily was given to patients aged 8 years and above for 10 days.

Dr. Aguirre is a Peru MD who believes more ivermectin is better, depending on the patients condition. His protocol's 4th revision graphically here, his day-old commentary here, and my Excel interpretation of his latest protocol here. (Argh: reddit will just show you my post, with two images both truncated. CLICK the image reddit shows to go to the tweet, then click the images there, using the right-arrow to see the second image (in case you're not twitter-adept).) The second image shows that his highest dose is 857mcg/kg.

I'm not an MD and this isn't medical advice.

If it was up to me, and I was not concerned about liability issues, I would go with Dr. Aguirre's protocol. It is battle-tested and refined. It also has lots of guidance about other drugs and treatments.

IMO liability should be a non-issue because of ivermectin's ridiculous safety record: 4+ billion doses given to billion(s) of people over 20+ years with < 6-8 deaths (and those are ambiguous, patients had myriad issues). I don't have the background to judge whether that would carry the day in court, though.

If your friends want the "cover" of using the FDA amount, that's 200mcg/kg. I would suggest giving that dose on days 1 - 3, then doing a PCR after a week and giving a second dose of the same size if the patient is still covid+.

And 10 days of doxycycline: it's safe and cheap, and appears to be helpful.

Any questions?

I hope this helps!

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