This is interesting (to me, at least) because it may explain the magical way ivermectin has long-lasting effects against parasite. One remarkable example was Papua, New Guinea villagers had 90% less scabies infections three years after treatment (a single dose, if memory serves -- it's on the sub). It may have implications for how often ivermectin needs to be taken for prophylaxis against covid19.
The study is about the longevity of ivermectin in blood and in other tissues, not just fat.
I'll write more after my walk. From a quick skim, this stood out:
In both groups there was a common tendency for a secondary peak to appear, suggestive of enterohepatic circulation. Accumulation of the parent drug in fat probably contributes to prolonged retention of ivermectin in the body
Ivermectin depletion appears very slow in most tissues. The pattern of differential distribution of ivermectin concentrations obtained in our human tissue samples was comparable to that seen in animals (Chiu and Lu 1989). The high concentration of ivermectin in fat is a function of the lipid solubility of the drug, and fat acts as a reservoir for ivermectin. This could explain previous observations that ivermectin was detected in human milk for 12 days following a single oral dose (Chiou et al. 1987).
1 dose, 12 days = every other week for prophylaxis? We don't know what concentration is needed, though, to fight off covid-19. Probably varies a lot depending on the health of the patient, e.g. obesity, vitamin A levels.
I going to hazard a guess before I look at the article: the blinded person recovered within 48 hours.
Edit: You should have mentioned that it was a friggin' lion that went blind. My guess was wrong: recovery took 3-4 days.
After ~72 h of ivermectin exposure, the lion started partially regaining weight on his legs independently and appeared to visually follow and paw at imaginary objects. The lion was discharged on 4th day after admission.
[-] TrumpLyftAlles | 2 points | Sep 28 2020 21:40:10
This is interesting (to me, at least) because it may explain the magical way ivermectin has long-lasting effects against parasite. One remarkable example was Papua, New Guinea villagers had 90% less scabies infections three years after treatment (a single dose, if memory serves -- it's on the sub). It may have implications for how often ivermectin needs to be taken for prophylaxis against covid19.
The study is about the longevity of ivermectin in blood and in other tissues, not just fat.
I'll write more after my walk. From a quick skim, this stood out:
In both groups there was a common tendency for a secondary peak to appear, suggestive of enterohepatic circulation. Accumulation of the parent drug in fat probably contributes to prolonged retention of ivermectin in the body
Ivermectin depletion appears very slow in most tissues. The pattern of differential distribution of ivermectin concentrations obtained in our human tissue samples was comparable to that seen in animals (Chiu and Lu 1989). The high concentration of ivermectin in fat is a function of the lipid solubility of the drug, and fat acts as a reservoir for ivermectin. This could explain previous observations that ivermectin was detected in human milk for 12 days following a single oral dose (Chiou et al. 1987).
1 dose, 12 days = every other week for prophylaxis? We don't know what concentration is needed, though, to fight off covid-19. Probably varies a lot depending on the health of the patient, e.g. obesity, vitamin A levels.
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[-] ibexrecurve | 2 points | Sep 29 2020 23:30:32
I wonder if taking it with lecithin would increase absorption. Just a random thought.
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[-] TrumpLyftAlles | 1 points | Sep 30 2020 01:01:42
Wow. I haven't heard about lecithin since my health-food-nut days in college in the '70's. ;)
What made you think of lecithin?
Wow again! Searching PubMed for "lecithin absorption" returned 646 articles!
Searching for "lecithine ivermectin" didn't return any articles.
Let me know if you find a couple fascinating maybe-ivermectin-relevant articles among the 646!
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[-] ibexrecurve | 1 points | Sep 30 2020 01:49:04
I only thought of lecithin because it's an emulsifier and ivermectin is not very water soluble.
An interesting article I came across was a case of blindess caused by a 10x overdose of ivermectin, then treated with some sort of lipid emulsion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660797/
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[-] TrumpLyftAlles | 2 points | Sep 30 2020 04:39:38
I going to hazard a guess before I look at the article: the blinded person recovered within 48 hours.
Edit: You should have mentioned that it was a friggin' lion that went blind. My guess was wrong: recovery took 3-4 days.
After ~72 h of ivermectin exposure, the lion started partially regaining weight on his legs independently and appeared to visually follow and paw at imaginary objects. The lion was discharged on 4th day after admission.
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