I'm posting this because This Week In Virology was panning Borody's ivermectin + doxycycline + zinc formula and one of the TWIV guys discussed his wife's comments on an previous episode, saying "You can only take it once every two weeks." Grrrr. They also raise the hated CONCENTRATION TOO HIGH!!! argument. Grrrr. Man, am I sick of that. {angry emoji}

Tne CDC says:

Crusted scabies: both oral and topical agents should be used

Ivermectin Brand name product: Stromectol Ivermectin is an oral antiparasitic agent approved for the treatment of worm infestations. Evidence suggests that oral ivermectin may be a safe and effective treatment for scabies; however, ivermectin is not FDA-approved for this use. The safety of ivermectin in children weighing less than 15 kg and in pregnant women has not been established. For crusted scabies, ivermectin should be administered together with a topical agent. Oral ivermectin (200µg/kg/dose) should be taken with food. Depending on infection severity, ivermectin should be taken in three doses (approximately days 1, 2, and 8), five doses (approximately days 1, 2, 8, 9, and 15), or seven doses (approximately days 1, 2, 8, 9, 15, 22, and 29).*

The CDC says you can take it 4 or 5 times in two weeks, depending on whether you consider Day 15 to be within the two-week span.

The CDC says approximately so I'll conclude it's approximately 5 times in two weeks, with the official CDC imprimatur.

If you're interested, the TWIV ivermectin comments start approximately here. It's about two minutes worth before they move on.

Note that their discussion ignores the placebo arm, which includes everything in the experiment arm except ivermectin and doxycycline.

Another argument is the Italy trial that's trying 1200mcg/kg daily for 5 consecutive days. That trial has a primary completion date of August 2020 and final completion October 2020. I wonder if we'll get results soon.

More importantly, there's supporting research for ivermectin + doxycycline, esp. the Bangladesh study.

I'm going to send them an email with Bangladesh and other information such as there being at least 60 trials underway. And knock them for discounting ivermectin based on an in vitro study. Bad science! It's an influential podcast.

permalink

I agree. They bring up this high dose was used in vitro all the time but Borody is using low dose and he constantly states this.. Drives me insane.

permalink

Professor Borody with his triple combination of Ivermectin Doxycycline and Zinc has been allowed in some of the Victorian Nursing homes now. He has also convinced the Federal Government to allow G.P.s to prescribe Ivermectin and his combination off label but still a lot of them are being advised against it. I am awaiting the results he gathers from his entry into our nursing homes.

permalink

Hi TrumpLyftAlles & jewelsn24 (& my Twitter contacts jjchanie & Hoytster). Sorry I've been out of contact for 3 weeks on Reddit. It certainly hasn't been for lack of action or interest. I've been busy on Twitter & email pushing Ivermectin (see my Twitter ID "@RhodusRod").

Re the in vitro hi (IVHi) dose quote out of Monash Uni (which we despise): On 06/10/2020, I emailed two individuals associated with Monash Uni ie Dr Kylie M. Wagstaff (kylie.wagstaff@monash.edu) & Associate Professor Steven Tong (steven.tong@mh.org.au) requesting that they explain or resolve the following conflictions & advise me accordingly:

Conflictions exist between the following two publications:

Pub1.   "The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro."

https://doi.org/10.1016/j.antiviral.2020.104787

Volume 178 dated June 2020. Author: Dr Kylie M. Wagstaff. [Monash Uni (Doherty Inst)]

Pub2.   https://www1.racgp.org.au/newsgp/clinical/insufficient-evidence-to-currently-support-ivermec

RACGP - Insufficient evidence to support ivermectin as COVID-19 treatment dated 15/08/2020.

(RACGP: Royal Australian College of General Practitioners)

Pub2 provides quotes by Associate Professor Steven Tong.

In Pub1, Dr Wagstaff suggests very positive expectations for the ability of Ivermectin in combatting the COVID-19 virus while in Pub2, Associate Professor Steven Tong suggests quite the opposite. This negative attitude is somewhat reflected in the title of Pub2: "Insufficient evidence to support ivermectin as COVID-19 treatment."

I have yet to receive a response to that email, but it was sent only 6 days ago  When (if?) I receive a response, I will advise. Cheers.

permalink