TrumpLyftAlles | 10 points | Sep 18 2020 23:46:51

Some doctors think they've found a cheap, generic drug which treats COVID-19. So why hasn’t anyone heard of it? (US 2020-09-18)

https://whyy.org/segments/some-doctors-think-theyve-found-a-cheap-generic-drug-which-treats-covid-19-so-why-hasnt-anyone-heard-of-it/

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[-] jewelsn24 | 6 points | Sep 19 2020 00:36:35

Professor Thomas Borody has been granted access to some of the nursing homes in Victoria Australia that have been hardest hit with Covid 19 to try out the triple treatment of Ivermectin ,Doxycycline and Zinc. He will report the results in a couple of weeks. He has been all over the media here trying to get the medical professionals to use it in Victoria which has been the hardest hit by this virus. The Federal Government has given him the go ahead and they have allowed the drug to be used off label for Covid19 but there is still a lot of opposition to it from our General Practitioners. His results from the nursing home trials at least will be available soon.

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[-] TrumpLyftAlles | 1 points | Sep 19 2020 03:34:39

That's great, that he can do the nursing home experiment. Is it actually going to be an experiment? Randomly assign nursing homes or residents to ivermectin / no-ivermectin groups? If it's just giving ivermectin to the whole nursing home, it's going to be much harder to get persuasive results. "More would have died without ivermectin, based on how many died before they go it." That's valid reasoning, but still not as persuasive as an actual RCT. "How do you know the lower fatality rate doesn't reflect less disease generally or improved hygiene?"

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[-] jewelsn24 | 4 points | Sep 19 2020 04:29:38

I'm not really sure how he is doing it at the moment. I only know he was allowed to use it in some of the hardest hit nursing homes but not all of them. Professor Borody is the same man who discovered the cure for peptic ulcers which has saved millions of lives so I assume he knows what he is doing. He is the same man who is partnering with the Dr in California to run and fund one of the RCT's out of their own pockets. I won't know how he is going to be doing this until he reports on the results in October. It will be interesting to see. He is lying his neck on the line for this triple combination therapy. He swears by it. If you google him Professor Borody triple therapy a lot of interesting information comes up.

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[-] TrumpLyftAlles | 1 points | Sep 19 2020 04:35:07

I think he's a BSer, grossly magnifying his role in ivermectin research (none) and claiming a 100% cure. I'm not sure he has used his triple therapy on a single patient. He hadn't when the first TV interview came out. "We're not using the therapy in Australia yet." or words close to that.

If the nursing home thing works out, he'll pump up interest for ivermectin. That's a good thing.

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[-] jewelsn24 | 5 points | Sep 19 2020 04:37:30

He is very well respected over here though and has plenty of money so I don't know why he would B.S. He is putting his reputation on the line. Anyway we shall see. I guess only time will tell. Hopefully it does help. It would be a game changer.

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[-] Positive11111 | 3 points | Sep 20 2020 04:11:17

Why are we letting mass media and pharmaceutical and institutions dominate from against using Ivermectin which is very cheap medication on helping out Covid-19 patients??? How long are we going to be pushed around??? Doctors had to use off label to treat patients with 99% success in USA.

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[-] [deleted] | 2 points | Sep 19 2020 06:24:48

Hi from Japan. I applaud you for your excellent work here. Very informative threads.

Apparently Dr. Borody has cured at least 15 patients with his triple treatments.

news.com.au

An “almost foolproof” three-pronged treatment for coronavirus symptoms is being rolled out in Victorian nursing homes, according to gastroenterologist Professor Thomas Borody. The Centre for Digestive Disease professor said the “triple therapy” involved Ivermectin, Doxycycline and zinc and “cured” at least 15 of his COVID-19 positive patients.

“Within 48 hours their cough had gone down and fever decreased – their oxygen levels had also significantly improved in that time,” Prof Borody told NCA NewsWire.

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[-] foggynotion | 2 points | Sep 19 2020 19:42:47

Wow hopefully the NPR coverage gets the ball rolling here in the US. Great news!

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[-] TrumpLyftAlles | 1 points | Sep 19 2020 00:16:11

This is a good ((mostly) accurate informative) article from a public radio station. It's a quick readable history with links.

Good quote from Dr. Chaccour:

“This is a safe drug for a non-treatable disease, so test it, by all means,” he said. “And if it doesn’t work, then put it to bed. And if it works, then jackpot.”

Writing about the taken-down April 19 "Usefulness of Ivermectin" paper (that was caught up in the Surgisphere scandal):

Patients who received ivermectin had a 65% reduction in the need for mechanical ventilation and an 83% reduction in overall death rate.

Also Chaccour:

“How about moral risk — people feeling `protected’ because they got their shot?” he said. He also noted that because parasites modulate the body’s immune response, massive deworming of a population where the prevalence of parasites is naturally high could affect the way an entire population responds to COVID-19 or other viruses.

I love this sentiment from Dr. Lieberman, who was asked by a desperate woman for advice about how to save her husband dying of covid-19. Lieberman looked over the options and recommended ivermectin, which worked (the article starts with this anecdote).

Back in Philadelphia, Alexis Lieberman was at her wits’ end. She recognized that unsanctioned, mass injections of Indigenous groups is “less than ideal,” but the way she saw it, a comprehensive study would put the issue to bed once and for all. She just could not understand why the FDA or a large research institution wouldn’t fund an ivermectin trial when it showed such promise.

“The truth is any country could complete a study on whether or not ivermectin helps COVID disease in the space of three weeks, and nobody’s done that,” Lieberman said. “It’s worth one big, fast, well-designed, well-funded study that I think the government should pay for.”

Omigosh, what a terrible error. Writing about the ICON study:

Rajter published the results of an analysis of his patients’ charts, which found a 10% reduction in mortality rate among severely ill COVID-19 patients who had been given ivermectin. His paper is in the process of being peer-reviewed for official publication.

In actually, it wasn't 10%, it was 52%. From ICON:

Mortality was also lower among patients with severe pulmonary involvement treated with ivermectin (38·8% vs 80·7%, OR 0·15, CI 0·05-0·47, p=0·001)

1 - (38.8 / 80.7) = .52

Wow: Lieberman tried to team up with Ratjer (ICON) to do a trial.

They estimate they could conduct a 300-person study like the one they proposed for a couple hundred thousand dollars.

Adam Gaertner says he needs $100,000. Good to know that is a reasonable estimate.

This is the first time I've seen a pronouncement from Merck about ivermectin and covid-19:

Merck, which originally developed ivermectin but whose patent on it expired, does not endorse its use for COVID-19 treatment. In a statement, a Merck representative said that “following detailed review of the evidence available for ivermectin we calculated that the dose required to attain an antiviral effect would significantly exceed the doses known to be safe and well tolerated,” referencing the in vitro study. “We therefore concluded that further research to evaluate the clinical potential of ivermectin for the treatment of SARS-CoV-2 was not warranted.”

Fucking CONCENTRATION TOO HIGH!!!!

Interesting information about Sabine Hazan, who is doing the California trial with Borody.

“I honestly think there’s something wrong with me because I play with poop, I play with a dangerous virus, and I’m in bed with Big Pharma,” Hazan said. “And let’s not forget the FDA!”

Because ivermectin is generic, Hazan knew there was no money to be made on this, but she wasn’t concerned about that for herself.

I don't think I believe this. In one of his interviews, Borody said he wanted to create a blisterpack with the drug cocktail they're testing. IMO that implies intent to patent the combo.

Hazan is paying for the clinical trial, which aims to recruit 300 patients, out of her own savings.

Elsewhere it's stated that the cost is $3500/subject for 300 subjects = $1,050,000. Nice savings account.

Hazan is paying for the clinical trial, which aims to recruit 300 patients, out of her own savings. Costs range from the medical equipment each patient will receive to monitor their improvement, such as Holter heart monitors and pulse oximeters, to the cost of hiring aides to draw blood regularly at patients’ homes. She said she is hopeful for investment from the pharmaceutical industry, but so far no companies have stepped up. She has worked with Merck in the past on drug trials, and approached the company about investing in ivermectin, but it wasn’t interested.

From google:

A Holter monitor uses electrodes and a recording device to track your heart's rhythm for 24 to 72 hours. Your doctor can print an electrocardiogram strip using the data on the recording device to see your heart's rhythm during the period you wore the monitor.

What a peculiar thing for an ivermectin trial?!

“Nobody wants to invest in trials in medications that are cheap because they’re not making any money,” Hazan said. “But these are billion-dollar companies. It’s time for them to give back. It’s more important to be a hero than it is to be rich.”

Or the NIH. Let's crowdsource it?!

She is about to start recruiting participants for the double-blind, randomized control trial, which Hazan anticipates will be a challenge.

“Trying to convince people to go on a trial where they may be on a sugar pill is a nightmare,” she said. “But it needs to be done.”

The article closes with Lieberman talking about a conspiracy to suppress ivermectin. She doesn't think there is one:

“You don’t need a cabal of people in a back room saying, ‘Let’s make sure this one doesn’t go because we’re gonna make more money off the other one,’” she said. “I just think you have a million small actors, who act in their small fields, and are completely ruled by what will make money.”

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[-] thaw4188 | 1 points | Sep 19 2020 15:56:53

that is actually a great article to get public attention and NPR picked it up so hopefully many will read it (despite the small errors)

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