Mostly interesting because it confirms that ivermectin inhibits importin alpha/beta.
Ivermectin This FDA-approved anti-parasitic drug has been shown to halt the replication of SARS-CoV-2 in vitro, as indicated by a several-fold reduction in viral RNA ivermectin-treated samples (64). However, further evaluation is needed to determine its efficacy in combating COVID-19 in humans. Ivermectin also shows broad-spectrum antiviral activity. It inhibits yellow fever virus replication, specifically targeting NS3 helicase activity (65). Ivermectin also inhibits HIV-1 (66) and Dengue virus (66, 67) replication by inhibiting importin alpha/beta, which facilitates the transport of proteins between the cytoplasm and nucleus, as these viruses use these proteins for their replication.
[-] TrumpLyftAlles | 1 points | Aug 28 2020 08:52:50
Mostly interesting because it confirms that ivermectin inhibits importin alpha/beta.
Ivermectin This FDA-approved anti-parasitic drug has been shown to halt the replication of SARS-CoV-2 in vitro, as indicated by a several-fold reduction in viral RNA ivermectin-treated samples (64). However, further evaluation is needed to determine its efficacy in combating COVID-19 in humans. Ivermectin also shows broad-spectrum antiviral activity. It inhibits yellow fever virus replication, specifically targeting NS3 helicase activity (65). Ivermectin also inhibits HIV-1 (66) and Dengue virus (66, 67) replication by inhibiting importin alpha/beta, which facilitates the transport of proteins between the cytoplasm and nucleus, as these viruses use these proteins for their replication.
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