COVID-19: Ivermectin Pre-Exposure Prophylaxis for Exposed Persons (Peru 2020-07 Aguirre)

[-] TrumpLyftAlles | 6 points | Aug 27 2020 02:19:45

Evidence for ivermectin providing prophylaxis!

Abstract Pre-exposure Prophylaxis (PrEP) consists of people at high risk of contracting COVID-19 taking medications periodically to prevent the virus from establishing in the mucosa and spreading through the body. When taken weekly or every 2 weeks, we are observing that it has a high effectiveness in preventing contracting COVID-19. PrEP becomes less effective when it is taken every 30 to 45 days. In people who have been using PrEP, we are seeing that Ivermectin reduces the risk of contracting the virus by approximately 99% when taken weekly, and by 94% if taken every 2 weeks (every 14 days). In people who are not exposed to places with high viral load, it could be justified to give doses every 14 days,

TLATODO: Look at the PDF (can't find it, dammit. I tweeted to the good doctor asking for a link, but it looks like he's on twitter only once in a while).

Edit: Dr. Aguirre did post a PDF, but I'm not sure it's actually related to this result. See the speculation I posted below in response to ibexrecurve's question. TL;DR: probably not related?

[-] luisvel | 3 points | Aug 27 2020 15:19:25

I also did a good search. Looks like there is no PDF. This is too good to be true for me. I would really like to see the data.

[-] TrumpLyftAlles | 1 points | Aug 27 2020 18:09:41

This is too good to be true for me.

I agree, though maybe not in the same sense.

we are seeing that Ivermectin reduces the risk of contracting the virus by approximately 99% when taken weekly, and by 94% if taken every 2 weeks (every 14 days).

That makes it sound like Dr. Aguirre actually has data, which would be excellent -- almost too good to be true.

[-] luisvel | 2 points | Aug 27 2020 22:26:20

Those numbers are unfortunately too high to be true. I would love to see the data showing I am wrong but this will probably show a very low n or no control arm. I would still be really excited to see the data.

[-] TrumpLyftAlles | 2 points | Aug 28 2020 00:22:34

Agreed. I think Dr. Aguirre is a man of integrity -- based on zilch. Who knows? It's weird to publish an abstract and no paper, presumably it's out there somewhere.

[-] ibexrecurve | 3 points | Sep 14 2020 16:45:11

At what dosage?

[-] TrumpLyftAlles | 2 points | Sep 14 2020 17:08:28

Not specified, kind of. The following resolves to "I don't know but here's my best guess."

I asked Dr. Aquirre on twitter for the backing paper, and he posted the protocol for the Argentine prophylaxis study -- which had 2 protocols for ivermectin. It changed in July and Dr. Aguirre posted the above in July. I believe that the above is a preliminary result from the Argentine study and reflects their experience with the original protocol (based on the relatively small Ns), which calls for 1 drop of 200mcg with the 5 times/day nasal spray = 1mg/day. That amount seems improbably low though. I might be wrong about the 1 drop == 200mcg; that came from @jjchamie, not sure it's correct. @jjcjamie has no special knowledge of the liquid ivermectin that they used in Argentina, AFAIK.

This is a lot conjecture. Dr. Aquirre is in Peru. The connection to the Argentine study is my inference based on the good doctor replying to my tweet that he would produce the backing PDF in a week, then his posting the Argentine protocol 7-10 days after that (and not posting any other possible backing PDF after that). It makes sense IFF he was communicating with one of the Argentine researchers (which is plausible IMO) and the above was their preliminary result. I'm too embarrassed/shy to press Dr. Aguirre for confirmation of the connection in a public tweet, and he has messaging turned off on twitter. It doesn't really matter, since we have the Argentina study.

Edit: Thinking about what I have posted here... why didn't Dr. Aguirre mention carrageenan, if he's reporting preliminary results from the Argentina study? It seems like he would have. Maybe Dr. Aguirre was too busy to pull together the promised backing report and posted the Argentina protocol because he promised to post something?

Edit: It also doesn't make sense that Dr. Aguirre would say ivermectin is 99% protective when Argentina reports 100% effectiveness.

Just go with the Argentina study, which (beginning in July) calls for one 15mg dose taken weekly.

Edit: Maybe the confusion will be swept away if/when the Argentina team publishes their formal report (so far we just have a couple news stories reporting its results).

[-] ibexrecurve | 2 points | Sep 14 2020 17:29:17

That's about what I figured for the once weekly dosage based on the table. And from some other link you posted somewhere else, be sure to take it with Alpha Lipoic Acid!

[-] TrumpLyftAlles | 1 points | Sep 14 2020 17:44:05

Alpha Lipoic Acid

LOL. I am taking that, and had forgotten why!

Edit: The only mention of ALA in the sub (searching for "alpha lipoic acid") is [this post] (https://www.reddit.com/r/ivermectin/comments/illpea/effect_of_ivermectin_on_male_fertility_and_its/g3szivj/) by hypnotheorist about ALA reversing ivermectin's effect on fertility in rats -- which is moot for me, having been "fixed" years ago. Does that sound like the post you're remembering? Apparently I found motivation to take ALA somewhere else.

[-] ibexrecurve | 2 points | Sep 14 2020 18:05:46

It was this one (good thing I take notes!).

https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12891

[-] TrumpLyftAlles | 1 points | Sep 14 2020 18:14:00

Well done! Do you find that study troubling, if you're personally considering taking ivermectin?

[-] ibexrecurve | 2 points | Sep 14 2020 18:36:32

I personally do not find it troubling considering that I don't have any plans to reproduce. But I would think twice about it if I were younger and still wanted to have kids.

[-] rraak | 2 points | Aug 27 2020 16:31:06

I'm skeptical of the 99% and 94% claims - Does this account for people who also wear masks, social distance, etc, or are they claiming that ivermectin PrEP alone results in that high of a risk reduction? Point being I suspect there are other factors at play, though I'm fairly convinced by personal experience and the wider body of evidence that ivermectin does have some preventive effectiveness.

[-] strongerthrulife | 1 points | Aug 27 2020 11:44:20

I wish I could read the full report but still this is amazing