TrumpLyftAlles | 2 points | Aug 25 2020 21:19:34

Pharmacokinetic and safety study of co-administration of albendazole, diethylcarbamazine, Ivermectin and azithromycin for the integrated treatment of Neglected Tropical Diseases (Papua New Guidea 2020-08-20)

https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaa1202/5895050?redirectedFrom=fulltext

permalink

[-] TrumpLyftAlles | 1 points | Aug 25 2020 21:21:54

Looked for (adverse) drug interactions between azithromycin and ivermectin (and other drugs), found no problems.

The GMR of Cmax, AUC0–t, and AUC0–∞ for IVM, DEC, ALB-SOX, and AZI were within the range of 80–125% (GMR for AUC0–∞ for IVM, 87.9; DEC, 92.9; ALB-SOX, 100.0; and AZI, 100.1).

Can anyone explain what ivermectin's GMR = 87.9 means?

permalink