This article has a lot more detail than the image included in the post about the same case, Serious Ivermectin Toxicity....
The 13-year-old's mutation prevented effective operation of the P-gp pump that keeps ivermectin and other things out of the brain.
P-gp is a pump that enables the efflux of toxins and drugs such as ivermectin, thus protecting the brain. In this case, the gene displayed two different mutations, each inherited from one of the parents. These “nonsense” mutations generate two incomplete copies of the protein and lead to a loss of its function. Because P-gp was no longer playing its barrier role, ivermectin entered the brain of this patient and became toxic. This is the first case of non-functional P-gp to have been described in humans.
Again, no number about how rare the mutations are, just:
The mutations discovered here are extremely rare in the general population
Maybe -- 1 in 7 billion?
Ivermectin has been given to billion(s) of people. I've seen 1.7 to 3.4 billion -- but just in tweets, not an authoritative source. I don't quote those numbers.
This is such a dramatic result -- CNS problems after 2.5 hours, coma after 6 -- that you would think people would have noticed the problem, if the mutations were NOT extremely rare.
Three patients went into coma, two recovered, the third died. The fatal case was someone recovering after having their aortic valve replaced (if I understood the medical shorthand correctly).
One of the two recovered patients had the CNS problems: Confusional state, amnesia, malaise, emesis. ATTENTION: "Similar symptoms reported twice in the past after ivermectin." This guy had CNS problems 3 times with ivermectin. Sounds like he might have the same mutation?
[-] TrumpLyftAlles | 1 points | Aug 24 2020 00:35:47
This article has a lot more detail than the image included in the post about the same case, Serious Ivermectin Toxicity....
The 13-year-old's mutation prevented effective operation of the P-gp pump that keeps ivermectin and other things out of the brain.
P-gp is a pump that enables the efflux of toxins and drugs such as ivermectin, thus protecting the brain. In this case, the gene displayed two different mutations, each inherited from one of the parents. These “nonsense” mutations generate two incomplete copies of the protein and lead to a loss of its function. Because P-gp was no longer playing its barrier role, ivermectin entered the brain of this patient and became toxic. This is the first case of non-functional P-gp to have been described in humans.
Again, no number about how rare the mutations are, just:
The mutations discovered here are extremely rare in the general population
Maybe -- 1 in 7 billion?
Ivermectin has been given to billion(s) of people. I've seen 1.7 to 3.4 billion -- but just in tweets, not an authoritative source. I don't quote those numbers.
This is such a dramatic result -- CNS problems after 2.5 hours, coma after 6 -- that you would think people would have noticed the problem, if the mutations were NOT extremely rare.
From Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis?, here is Table 1 which lays out what happened to the 28 most serious neurological adverse events they found in a database of 1600+ AEs.
Three patients went into coma, two recovered, the third died. The fatal case was someone recovering after having their aortic valve replaced (if I understood the medical shorthand correctly).
One of the two recovered patients had the CNS problems: Confusional state, amnesia, malaise, emesis. ATTENTION: "Similar symptoms reported twice in the past after ivermectin." This guy had CNS problems 3 times with ivermectin. Sounds like he might have the same mutation?
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