One of the drugs with the potential for COVID-19 treatment is ivermectin. This antiparasitic drug has shown potential antiviral activity by inhibiting the nuclear transport of viral proteins [18–22].
Previous studies on SARS-CoV proteins have shown the potential role of IMPα/β1 during infection in the signal-dependent nucleocytoplasmic shuttling of the SARS-CoV nucleocapsid protein, which may affect host cell division [21,33]. Moreover, open reading frame (ORF) 6, as the accessory protein of SARS-CoV, has been shown to have an antagonistic effect against the antiviral activity of the STAT1 transcription factor [34]. As ivermectin has shown a potential inhibitory effect on nuclear transport, particularly by preventing IMPα/β1 binding, it may also act on SARS-CoV-2. As SARS-CoV-2 is very similar to SARS-CoV, it is suggested that ivermectin may also be effective against SARS-CoV-2 by inhibiting its nuclear transport [25]. A proposed schematic figure of the antiviral action of ivermectin against SARS-CoV 2 is depicted in Figure 1.
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Excerpts:
One of the drugs with the potential for COVID-19 treatment is ivermectin. This antiparasitic drug has shown potential antiviral activity by inhibiting the nuclear transport of viral proteins [18–22].
Previous studies on SARS-CoV proteins have shown the potential role of IMPα/β1 during infection in the signal-dependent nucleocytoplasmic shuttling of the SARS-CoV nucleocapsid protein, which may affect host cell division [21,33]. Moreover, open reading frame (ORF) 6, as the accessory protein of SARS-CoV, has been shown to have an antagonistic effect against the antiviral activity of the STAT1 transcription factor [34]. As ivermectin has shown a potential inhibitory effect on nuclear transport, particularly by preventing IMPα/β1 binding, it may also act on SARS-CoV-2. As SARS-CoV-2 is very similar to SARS-CoV, it is suggested that ivermectin may also be effective against SARS-CoV-2 by inhibiting its nuclear transport [25]. A proposed schematic figure of the antiviral action of ivermectin against SARS-CoV 2 is depicted in Figure 1.
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