TrumpLyftAlles | 3 points
Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action (Italy 2020-05-27)I think they mean another kind of ionophore, basically anything that assists crossing a membrane can be an ionophore and ivermectin is complex enough that it has several mechanisms?
someone really needs to do some computer modeling on ivermectin but there's no motivation in it because there's no profit and no money to fund studies
it also can fight some flu viruses so even after covid there's purpose
maybe after the election there will be some more motivation by the CDC/NIH to study it but I'm not holding my breath, I think there would have to be a major endorsement by a 1st world country government to get them to open their eyes
[-] TrumpLyftAlles | 1 points | Aug 18 2020 23:20:38
I found this article while browsing for evidence that ivermectin is a zinc ionophore. I read the following as "it is theoretically possible that ivermectin is a zinc ionophore" and mostly implying that it is probably NOT an ionophore.
What's your reading?
However, ivermectin could prove to be a powerful antiviral, therefore also useful for a possible treatment of the new coronavirus associated syndrome, even from a new perspective. This could happen assuming its role as an ionophore agent, only hinted in the recent past but never fully described (Juarez et al. 2018). Ionophores are molecules that typically have a hydrophilic pocket which constitutes a specific binding site for one or more ions (usually cations), while its external surface is hydrophobic, allowing the complex thus formed to cross the cell membranes, affecting the hydro-electrolyte balance (Freedman 2012).
At a first glance, the two structures that make up the ivermectin formula do not have these chemical properties, nor those mentioned above, essential for a compound to be defined as ionophore. However, it can be hypothesized that two ivermectin molecules, reacting with each other in a “head-tail” mode, can create a complex suitable to be considered such (Fig. (Fig.2).2). This interaction could occur spontaneously or be mediated by the binding of the same molecules to some plasma transport proteins, in particular albumin (Klotz et al. 1990), which would have the role of positioning them in the correct way to obtain the proposed configuration.
permalink