TrumpLyftAlles | 1 points | Jul 27 2020 15:42:26

Ivermectin induced Steven–Johnsons syndrome (Bali, Indonesia, 2017)

https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2500-5

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[-] TrumpLyftAlles | 1 points | Jul 27 2020 15:47:56

Person with HIV has bad negative reaction to ivermectin, was treated and recovered. Note that there was a nationwide anti-filarial campaign. That means they gave everyone (maybe?) ivermectin to prevent filariasis.

Abstract Background Stevens–Johnson syndrome is one of the manifestations of mucocutaneous adverse drug reactions. Although antimicrobials are responsible for greater than 50% of these adverse drug reactions, there is no documented case implicating ivermectin as the culprit.

Case summary A 38 year old adult Cameroonian male presented to our health facility with facial rash, painful oral sores, black eschars on lips and red tearing eyes 3 days following ingestion of ivermectin received during a nationwide anti-filarial campaign. He had no known chronic illness, no known allergies and was not on any medications prior to the campaign. Physical examination revealed discharging erythematous eyes, crusted and blister-like lesions with cracks on his lips and oral mucosa. His laboratory tests were unremarkable but for a positive Human Immunodeficiency Virus (HIV) test. A diagnosis of Ivermectin induced Stevens–Johnson syndrome in a newly diagnosed HIV patient was made. The patient was managed with supportive therapy and the evolution thereafter was favourable.

Conclusion Stevens–Johnson syndrome is a potential side effect of ivermectin and susceptibility to this adverse effect may be increased in HIV infection.

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[-] foggynotion | 1 points | Jul 27 2020 16:26:42

Interesting... I was doing some more searches and I really couldn't find any other examples of ivermectin induced SJS. Seems to be an extremely rare interaction, couldn't find any others than this one. Thanks for the link

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[-] TrumpLyftAlles | 1 points | Jul 27 2020 16:40:38

Bali's population is 4.22 million.

Bali to reopen to international tourists on Sept. 11

As of Friday, Bali had recorded 3,058 cases of COVID-19 consisting of 3,036 locals and 22 foreigners. The province has seen 2,321 recoveries and 48 deaths. (nal)

Bali is in Indonesia, which has 366 cases/million and 18 deaths/million.

Bali has 724 cases/million and 11 deaths/million.

So Bali has twice as many cases but 2/3rds as many deaths (per million) as Indonesia as a whole.

Worldwide, as of 2020-07-27, there have be 16,513,180 cases and 653,789 deaths for a Incident Fatality Rate (IFR) of 0.040. Bali's IFR = 11 / 3036 (leaving out the foreigners who very likely did not receive ivermectin) = 0.0036, which is 1 11th of the world IFR. That is, if covid-19 killed Balinese who catch the virus at the world rate of death, then 11 times as many Balinese would have died.

There could be lots of explanations, such as age. The average Bali age is 30 vs 38 in the US and 45 in Italy. Not urban. Maybe there's little air conditioning? LOL: The average low temperature by month varies between 72 and 73 F, average high between 84 - 88.

It would be helpful to know (1) what portion of Balinese were treated with ivermectin and (2) how much has ivermectin been used in Indonesia generally. IVERTODO Look harder.

In the meantime, this doesn't prove that ivermectin helped reduce the IFR in Bali ... but it IS suggestive, isn't it? Or am I seeing it through ivermectin-colored glasses. ;)

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