Ivermectin question, kinda long

[-] stereomatch | 5 points | Jul 27 2020 06:53:22

Azithromycin prevents other opportunistic bacterial etc. infections from taking hold. And may have other mechanisms by which it works as well.

The blood clotting is seen to be a side effect of runaway inflammation - the so-called cytokine storm. Supposedly this can damage blood vessels enough to release clotting factors.

So it may not just be those with vascular comorbidities, but anyone who is going to have a severe inflammatory reaction.

So for example post-recovery some patients have strokes. That is supposedly because of the upregulated immune system which is taking it's time to dial down.

[-] BlendedPastaman3 | 2 points | Jul 27 2020 15:50:37

Ok. I did not realize that the clots damage the walls enough to release clotting factors. Thank you for your explanation!

[-] stereomatch | 3 points | Jul 27 2020 15:56:16

Check out some of the videos by Medcram on Youtube where he discusses N-acetylcysteine, inflammation etc.

Dr Been covers similar material.

[-] Haitchpeasauce | 3 points | Aug 01 2020 13:02:10

Dr Been is a gift to the world I do hope his lectures receive more attention.

[-] BlendedPastaman3 | 2 points | Jul 27 2020 16:00:57

Will do. Thanks!

[-] stereomatch | 3 points | Jul 27 2020 16:04:52

Medcram:

https://youtu.be/bPDVzt79UMU

https://youtu.be/kK-DNyKnb5c

[-] stereomatch | 2 points | Jul 27 2020 16:10:46

The perception now is that covid19 is primarily damaging via clotting factors - which is why disease presents itself in such varied fashion.

medcram #95 video

https://youtu.be/bPDVzt79UMU

widespread clotting on autopsy

at 25:50 minute mark:

all this casting light on what is going on here with the pathophysiology

thrombosis - particularly with platlets, fibrin, megakaryocytes is what is leading us to the hypoxic mechanisms with covid19

he thinks thrombosis may occur very early perhaps earlier than when present to hospital

and may be why disease presents itself in such varied form wide range of symptoms ie it just depends on where thrombosis occurs

if thrombosis occurs in brain, going to get neurological symptoms if thrombosis occurs in lungs, going to get shortness of breath symptoms (blood flow through lungs for oxygenation is hindered) if thrombosis in kidney, going to get renal issues

more research is needed to prevent these catastrophic micro-thrombi from occuring

[-] foggynotion | 2 points | Jul 27 2020 16:39:10

In the most recent studies it seemed to me they aren't focusing so much on combining with azithromycin, there was a few studies where they included it but didn't show much improvement. So far the best studies on ivermectin have been just from the single dose method combinded with doxycycline. Curious if any come out that include Zinc

[-] rraak | 2 points | Jul 28 2020 01:27:35

I question the use of azithromycin as well. I don't like taking antibiotics unless absolutely necessary due to the havoc they cause in my digestive system, so that's one path where I'd prefer having some fairly solid answers before just using the ivermectin on its own or in combination with other non-antibiotic drugs.

[-] Haitchpeasauce | 2 points | Aug 01 2020 13:23:36

Found a comment by the paper's author regarding this https://www.reddit.com/r/COVID19/comments/hk75iz/comment/fx45o3b

IVM appears to reverse the effect of red blood cell clumping caused by SARS-CoV-2 binding to CD147.

IVM doesn't block ACE2 but protects the cell's nucleus, which coronavirus is disrupting from producing interferons. Very cool with broad potential for antiviral applications.

[-] DZinni | 1 points | Aug 01 2020 00:17:43

I don't think Ivermectin blocks the ACE2 receptors.