CD147 is a protein on the red blood cell (RBC). It is the entry point for malaria into the blood cell. CD147 might be a binding site for COVID-19 -- even though that doesn't help the virus replicate because blood cells don't have the machinery. The idea is that when the virus binds to blood cells, they clump together into blood clots. Ivermectin is supposed to bind to the covid19 spike -- which would prevent the clotting.
Turning to the paper's few sentences about the ICON study (Broward County) -- fatalities were reduced 42% overall, 52% among patients with pulmonary disease.
This is a NEW idea, that ivermectin prevents binding with RBCs.
Ivermectin may have several anti-viral activities helpful with covid-19. In Monash, the therapeutic dose is in the 20-80 microgram range, while the blood levels at safe therapeutic doses are in the nanogram range. So "concentration too high!" again - sigh -- and we have to test in patients again -- deep sigh.
[-] TrumpLyftAlles | 1 points | Jul 23 2020 21:06:02
The MedCram guy discusses Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion (which was discussed in this sub here three weeks ago) beginning here in the youtube video.
CD147 is a protein on the red blood cell (RBC). It is the entry point for malaria into the blood cell. CD147 might be a binding site for COVID-19 -- even though that doesn't help the virus replicate because blood cells don't have the machinery. The idea is that when the virus binds to blood cells, they clump together into blood clots. Ivermectin is supposed to bind to the covid19 spike -- which would prevent the clotting.
Turning to the paper's few sentences about the ICON study (Broward County) -- fatalities were reduced 42% overall, 52% among patients with pulmonary disease.
This is a NEW idea, that ivermectin prevents binding with RBCs.
Right after the Quasi-Threshold paper, starting at 11:20, D. SeHeult turns to Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen which appears in this sub here.
Ivermectin may have several anti-viral activities helpful with covid-19. In Monash, the therapeutic dose is in the 20-80 microgram range, while the blood levels at safe therapeutic doses are in the nanogram range. So "concentration too high!" again - sigh -- and we have to test in patients again -- deep sigh.
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