This is another "ivermectin deserves clinical trials" article. It lists the dose and N's of 9 trials; I don't know if they are all on ClinicalTrials. (I should create a similar but exhaustive list.)
This has some possible mechanisms for ivermectin's action against COVID-19, some I was unaware of (or have just forgotten). The remark about importin α/β is known. This study suggests, however, that only IMP α is inhibited (I emailed an author asking about that).
Ivermectin, a well-known anti-helmintic agent from the late-1970s, causes stimulation of gamma amino butyric acid (GABA)-gated-Cl− channels, leading to hyperpolarization, and resulting in paralysis of the infesting organism. Another mechanism that has been postulated for the same effect is the immunomodulation of host response. This is attained by the activation of neutrophils, increase in the levels of C-reactive protein and interleukin-6. In recent times, the antiviral function of ivermectin has been discovered, which appears to be intriguing.
Already its effectiveness against certain flavivirus (dengue fever, Japanese encephalitis and tick-borne encephalitis virus) and chikungunya virus has been demonstrated in vitro. Since then the same activity has been assessed in numerous other viral infections. Off lately its potency has been recognized in eliminating coronavirus in vitro. The exact mechanism to which this effect can be attributed to is yet to be validated, but the speculated method is inhibition of importin α/β1 mediated transport of viral proteins in and out of the nucleus. Importins, a type of karyopherins, exemplify a major class of soluble transport receptors which are involved in nucleo-cytoplasmic transit of various substrates. The speculated inhibitory action of ivermectin on importin α/β mediated transport system, Based on this conjecture, the role of ivermectin in eliminating Covid-19 can be assumed.
Glossary:
Hyperpolarization is a change in a cell's membrane potential that makes it more negative. It is the opposite of a depolarization. It inhibits action potentials by increasing the stimulus required to move the membrane potential to the action potential threshold.
Immunomodulation. Change in the body's immune system, caused by agents that activate or suppress its function.
Neutrophils are a type of white blood cell that helps heal damaged tissues and resolve infections. ... The body produces neutrophils in the bone marrow, and they account for 55–70 percent of all white blood cells in the bloodstream.
[-] TrumpLyftAlles | 2 points | Jul 09 2020 19:07:15
This is another "ivermectin deserves clinical trials" article. It lists the dose and N's of 9 trials; I don't know if they are all on ClinicalTrials. (I should create a similar but exhaustive list.)
This has some possible mechanisms for ivermectin's action against COVID-19, some I was unaware of (or have just forgotten). The remark about importin α/β is known. This study suggests, however, that only IMP α is inhibited (I emailed an author asking about that).
Ivermectin, a well-known anti-helmintic agent from the late-1970s, causes stimulation of gamma amino butyric acid (GABA)-gated-Cl− channels, leading to hyperpolarization, and resulting in paralysis of the infesting organism. Another mechanism that has been postulated for the same effect is the immunomodulation of host response. This is attained by the activation of neutrophils, increase in the levels of C-reactive protein and interleukin-6. In recent times, the antiviral function of ivermectin has been discovered, which appears to be intriguing.
Already its effectiveness against certain flavivirus (dengue fever, Japanese encephalitis and tick-borne encephalitis virus) and chikungunya virus has been demonstrated in vitro. Since then the same activity has been assessed in numerous other viral infections. Off lately its potency has been recognized in eliminating coronavirus in vitro. The exact mechanism to which this effect can be attributed to is yet to be validated, but the speculated method is inhibition of importin α/β1 mediated transport of viral proteins in and out of the nucleus. Importins, a type of karyopherins, exemplify a major class of soluble transport receptors which are involved in nucleo-cytoplasmic transit of various substrates. The speculated inhibitory action of ivermectin on importin α/β mediated transport system, Based on this conjecture, the role of ivermectin in eliminating Covid-19 can be assumed.
Glossary:
Hyperpolarization is a change in a cell's membrane potential that makes it more negative. It is the opposite of a depolarization. It inhibits action potentials by increasing the stimulus required to move the membrane potential to the action potential threshold.
Immunomodulation. Change in the body's immune system, caused by agents that activate or suppress its function.
Neutrophils are a type of white blood cell that helps heal damaged tissues and resolve infections. ... The body produces neutrophils in the bone marrow, and they account for 55–70 percent of all white blood cells in the bloodstream.
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