So Ivermectin is contraindicated in patients with a compromised blood brain barrier. People with MS (Multiple Sclerosis), typically have a compromised BBB at the time of an MS attack. I was curious if there were any studies involving ivermectin on MS patients. That's when I found this study. Ivermectin may promote remyelination.
Now I'm really confused on if Ivermectin is contraindicated with people with permeable BBB. Need to travel down the rabbit hole. Need to find out if they followed up this study with human trials.
When ivermectin crosses the BBB -- is there some reason to think that's seriously dangerous?
I don't know if you will find this comforting or persuasive -- but the study discussed here looked at 1600+ severe neurological adverse events attributed to ivermectin. Out of the billions of doses given to billion(s) of people over two decades, there were only 1600+ such events. Only 28 cases were especially severe. Only 2 people died and both of them had myriad other things going on, so ivermectin might not have been the cause of death.
There's also this case report of a woman who developed Central Nervous System symptoms (implying penetration of the BBB) after taking 12mg of ivermectin every day for 2 weeks. Her symptoms improved 2 days after she stopped taking the drug and she left the hospital the next day.
scientist can use ivermectin to turn off parts of the brain.
From my reading, only the brain of a specially-engineered mouse. Did you read something different? I imagine the mouse has a peculiarly porous blood-brain barrier.
[-] DZinni | 2 points | Jul 09 2020 03:20:08
Actual study is here: P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
So Ivermectin is contraindicated in patients with a compromised blood brain barrier. People with MS (Multiple Sclerosis), typically have a compromised BBB at the time of an MS attack. I was curious if there were any studies involving ivermectin on MS patients. That's when I found this study. Ivermectin may promote remyelination.
Now I'm really confused on if Ivermectin is contraindicated with people with permeable BBB. Need to travel down the rabbit hole. Need to find out if they followed up this study with human trials.
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[-] TrumpLyftAlles | 1 points | Jul 09 2020 05:01:18
When ivermectin crosses the BBB -- is there some reason to think that's seriously dangerous?
I don't know if you will find this comforting or persuasive -- but the study discussed here looked at 1600+ severe neurological adverse events attributed to ivermectin. Out of the billions of doses given to billion(s) of people over two decades, there were only 1600+ such events. Only 28 cases were especially severe. Only 2 people died and both of them had myriad other things going on, so ivermectin might not have been the cause of death.
There's also this case report of a woman who developed Central Nervous System symptoms (implying penetration of the BBB) after taking 12mg of ivermectin every day for 2 weeks. Her symptoms improved 2 days after she stopped taking the drug and she left the hospital the next day.
It's a safe drug, IMO.
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[-] TrumpLyftAlles | 1 points | Jul 11 2020 19:07:11
Need to travel down the rabbit hole.
What have you learned? I'm curious too.
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[-] DZinni | 2 points | Jul 12 2020 03:49:45
I learned it isn't as studied as much as I hoped.
I also learned that scientist can use ivermectin to turn off parts of the brain.
https://www.sciencedaily.com/releases/2016/06/160630140516.htm
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[-] TrumpLyftAlles | 1 points | Jul 12 2020 08:32:00
scientist can use ivermectin to turn off parts of the brain.
From my reading, only the brain of a specially-engineered mouse. Did you read something different? I imagine the mouse has a peculiarly porous blood-brain barrier.
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[-] DZinni | 2 points | Jul 12 2020 13:41:12
It's not too detailed on the method. Genetically engineered brain with receptors that accept ivermectin on the surface of a certain section.
They stuck probes directly into the brain, so I would assume they injected ivermectin directly into the brain too.
Just interesting. Don't think too much can be drawn from article.
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