This video does a very good job of explaining how Ivermectin works in the cells to combat the coronavirus. He also gives a good overview of Ivermectin itself. The information Drbeen presents is 4 months old. He does not go into any of the more recent Ivermectin trials or the anecdotal information regarding the medicine (I don't think he knows about it).

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Although it is nearly the same information MedCram did a video on April 8th, I do think Drbeen did a much better job presenting it.

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My rough notes:

Contraindicated for people with a compromised blood brain barrier; it will interfere with GABA. Similarly, pregnant women shouldn't use it because the fetus as a poor blood brain barrier.

When ivermectin enters the cell, it becomes hyper-polarized. That makes the cell hard to be active. Action potential generation is inhibited. This applies to bugs, not people.

Looking at doses: 150 - 200mcg / kg one a year, for parasites.

Monash: ivermectin attaches to the IMP alpha/beta1 transport and prevents entry to the nucleus. Ivermectin thus blocks the virus from replicating and disabling the cell's anti-virus activity.

Ivermectin wasn't useful against the Dengue virus.

Monash says ivermectin will reduce the virus load, so the body's immune system can function and clear the virus. The cell can protect itself better because the virus is not admitted to the nucleus, where it would otherwise disable the cell's defenses.

"No toxicity was oberved with ivermectin at any of the concentrations tested."

A doctor at Baylor says we need to figure out the right dose, to use against this virus.

I seriously doubt that there's an issue with ivermectin and pregnant women.

It has been used in Mass Drug Administrations to fight parasites for over two decades. In 2019, it was given to 540 million people. Even if pregnant women are told not to take the drug, during an MDA -- at least a 9th, probably more, do not know they are pregnant at the time. This says that about 4.4% of American women were pregnant in 2006. Let's go with 5%, because this is Africa, etc., mostly not developed nations where the birth rate is higher. If we say women don't know they are pregnant for 1 month (the minimum):

5% * 540,000,000 / (12 months * 2) = 1,125,000

(divide by 2 because only half are women)

So every year, at least 1 million women take ivermectin in an MDA while pregnant. This has gone on for more than 2 decades. The MDAs didn't start out at 540 million per year. Let's say the average MDA was half that. It adds up to about 10 million pregnant women taking ivermectin. It could easily be 15 million, given my low-side assumptions.

I'm pretty sure that if a significant portion of 10 (or 15) million babies were having birth defects, someone would have noticed and put it together with the administrations of ivermectin.

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Interesting comment from YouTube

Knight Defender 3 days ago

Prior to 2010, scientists believed that the blood-brain barrier did not develop until after birth, based on the belief that astrocytes did not develop until after birth. Researchers at Stanford University and the University of California, San Francisco, discovered in 2010 that pericytes, not astrocytes, are required for blood-brain barrier development and that pericytes are present in the fetal brain. The research proves that your infant’s blood-brain barrier is fully developed well before birth.

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