This article may explain why ivermectin has such mysteriously long-lasting effects, e.g. two years after a single dose, parasite infestations are 90% lower than originally: the molecule accumulates in fats. This could have negative consequences for insect life, a bad thing. It also suggests (to me, only, probably) that if ivermectin is prophylactic against COVID-19, then frequent dosing might not be required -- because it is retained in the human's fat store. The article doesn't actually touch on ivermectin and humans.
Research 'Biomagnifcation and body distribution of ivermectin in dung beetles' from the University of Alicante (UA) has confirmed that ivermectin, the most widely used antiparasitic in livestock, bioaccumulates in the tissues of insects. This bioaccumulation has more negative effects than previously thought since, according to research published in Scientific Reports, the molecule rapidly bioaccumulates in insects, especially in the fatty body, increasing its toxicity, and passing to food chain.
In the work they have verified how ivermectin is quickly transferred from the intestine to the hemolymph, internal circulation fluid of the invertebrates, generating a biomagnification factor three times greater in the hemolymph than in the intestine after a 12-day absorption period. These highly toxic levels are transferred to other animals such as bee-eaters, black kites, choughs, genets, melons, and foxes, which feed on these insects.
Hemolymph is the bug equivalent of blood.
"Biomagnification occurs, that is, the successive propagation of the bioconcentration of this toxicity to living beings that make up the links in the food chain, and therefore to humans," clarifies UA researcher José R. Verdú.
Bad for dung beetles.
Given ivermectin's incredible safety record, this article doesn't alarm me.
[-] TrumpLyftAlles | 2 points | Jul 01 2020 23:23:03
This article may explain why ivermectin has such mysteriously long-lasting effects, e.g. two years after a single dose, parasite infestations are 90% lower than originally: the molecule accumulates in fats. This could have negative consequences for insect life, a bad thing. It also suggests (to me, only, probably) that if ivermectin is prophylactic against COVID-19, then frequent dosing might not be required -- because it is retained in the human's fat store. The article doesn't actually touch on ivermectin and humans.
Research 'Biomagnifcation and body distribution of ivermectin in dung beetles' from the University of Alicante (UA) has confirmed that ivermectin, the most widely used antiparasitic in livestock, bioaccumulates in the tissues of insects. This bioaccumulation has more negative effects than previously thought since, according to research published in Scientific Reports, the molecule rapidly bioaccumulates in insects, especially in the fatty body, increasing its toxicity, and passing to food chain.
In the work they have verified how ivermectin is quickly transferred from the intestine to the hemolymph, internal circulation fluid of the invertebrates, generating a biomagnification factor three times greater in the hemolymph than in the intestine after a 12-day absorption period. These highly toxic levels are transferred to other animals such as bee-eaters, black kites, choughs, genets, melons, and foxes, which feed on these insects.
Hemolymph is the bug equivalent of blood.
"Biomagnification occurs, that is, the successive propagation of the bioconcentration of this toxicity to living beings that make up the links in the food chain, and therefore to humans," clarifies UA researcher José R. Verdú.
Bad for dung beetles.
Given ivermectin's incredible safety record, this article doesn't alarm me.
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