[-] TrumpLyftAlles | 1 points | Jun 21 2020 04:11:20

Great find! This is the report on this trial:

A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh

(How did you find it?!) (Never mind, who cares? :)

Abstract and Figures

Coronavirus disease 2019 (COVID19) is a WHO declared a global pandemic. From the time of origin to till many antiviral and other drugs are on desperate use to find a cure. We decided to investigate the efficacy of Ivermectin-Doxycycline combination therapy and compare it to the standard HCQ-Azithromycin therapy among the mild to moderate cases of COVID19 patients in Bangladesh. Patients were divided into two groups. Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10d and Hydroxychloroquine 400mg 1st day then 200mg BID for 9days + Azithromycin 500mg daily for 5Days was given to the Group-A and group-B respectively. Treatment outcomes were evaluated on the 5th day in case of asymptomatic patients and the 2nd non-symptomatic day onward from the first day of the drug intake by PCR study. According to this study both the Ivermectin-Doxycycline and HCQ-Azithromycin treatment regimens were found to be effective against SARS-CoV-2 infection. But concerning the treatment outcome, adverse effect, and safety Ivermectin-Doxycycline combination is superior to HCQ-Azithromycin therapy for mild to moderate degree of COVID19 patients in Bangladesh. We strongly believe by rescheduling and increasing the duration of Ivermectin to 3days will certainly decrease the recovery period further than that of our study. This will also prevent disease progression and morbidity to COVID19 patients.

[-] DZinni | 2 points | Jun 26 2020 00:07:07

This is the same protocol for treating several parasites.

[-] TrumpLyftAlles | 1 points | Jun 26 2020 02:30:26

Ivermectin + doxycycline? Or do you mean, just the 200mcg/kg of ivermectin?

The FDA-approved dosing for a couple parasites is 200mcg/kg. A lot of trials and a number of MDs in the field have adopted that dose.

[-] DZinni | 2 points | Jun 26 2020 03:37:53

Both. I've seen the Ivermectin used at 200 mcg/kg for treating several parasites (some require lower so die off is less severe, I don't recall any higher dosages required.) I've also seen doxycycline used in combination with Ivermectin to kill some internal parasites. Doxycycline is used to kill the gut bacteria of the parasite.

I do wonder if the Doxycycline increases the effectiveness of Ivermectin in relation to COVID-19. I suspect it was added in because it is already a proven drug combo that likely wouldn't have a negative effect.

[-] TrumpLyftAlles | 1 points | Jun 26 2020 03:41:39

I've also seen doxycycline used in combination with Ivermectin to kill some internal parasites. Doxycycline is used to kill the gut bacteria of the parasite.

That's a TIL for me, thanks.

I do wonder if the Doxycycline increases the effectiveness of Ivermectin in relation to COVID-19. I suspect it was added in because it is already a proven drug combo that likely wouldn't have a negative effect.

There are a number of ivermectin-without-doxy trials underway so we'll know eventually. My sense is the doxy can't hurt, might help if there's a bacterial infection. That's 100% guesswork on my part.

[-] DZinni | 2 points | Jun 26 2020 03:58:39

It's a TIL for me too. It's been a while since I read about ivermectin as a potential drug to battle COVID (Only knew about the in vitro study at max safe dose). Now that my family has been exposed to a known cases of COVID, I wanted to see what the latest research shows and tested dosage. I was surprised to see doxy included so I wanted to know why.

[-] TrumpLyftAlles | 1 points | Jun 21 2020 04:30:53

There is a link on OP's page where you can download the PDF.

TL;DR:

Both ivermectin + doxycycline (IVMDX) and hydroxychloroquine + azithromycin (HCQAZT) were effective

IVMDX was (somewhat) superior

100% recovered vs 96.36% for HCQAZT
Recovery was faster, 8.93 days vs 9.33 days for HCQACT
Subjects had fewer side-effects with IVMDX

To me these sound like pretty niggling differences.

From the PDF:

#Abstract

Background: The COVID-19 pandemic in Bangladesh is part of the worldwide pandemic caused by a newly discovered Coronavirus. The treatment methods for COVID-19 are emerging and rapidly evolving because of ongoing researches being done worldwide by a record number of investigators. Researchers have investigated existing drugs, including Ivermectin as well as Hydroxychloroquine in addition to other existing drugs. In this research, we investigated and compared the outcome of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin combination therapy on mild to moderate degree of COVID19 patients.

Methods: Following exclusion, 116 patients tested positive by RT PCR for SARS-CoV-2 infection were included in this study. Patients were divided into two groups. Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10d and Hydroxychloroquine 400mg 1st day then 200mg BID for 9days + Azithromycin 500mg daily for 5Days was given to the GroupA and group-B respectively. Treatment outcomes were evaluated on the 5th day in case of asymptomatic patients and the 2nd non-symptomatic day onward from the first day of the drug intake by PCR study.

Results: Group-A recovery rate was 100%. The mean recovery duration was 8.93days. A mild degree of adverse effect was noted by 31.67% of patients; lethargy in 14(23.3%), nausea in 11(18.3%), and occasional vertigo in 7(11.66%) of patients. In group-B recovery rate was 96.36%. The mean duration of recovery was 9.33 days. 46.43% had experienced some degree of adverse effects; 13(23.21%) mild type of blurring of vision and headache; 22(39.2%) increased lethargy and dizziness, 10(17.85%) occasional palpitation, and 9(16.07%) experienced nausea and vomiting.

Conclusion: Concerning the treatment outcome, adverse effect, and safety, IvermectinDoxycycline combination is a better alternative to Hydroxychloroquine-Azithromycin therapy in the case of mild to moderate degree of COVID19 patients. Though, both the treatment regimens were found to be effective in this study

[-] jpdowlin | 1 points | Jun 22 2020 05:51:45

The cohorts were quite young in both arms of this study (median age was mid 30s, if i remember). So you expect high recovery rates. It's another positive sign that Ivermectin could be a game changer. But I'm afraid, it won't convince anybody with influence in the West about pushing Ivermectin.