104 patients were given medicine in Kanpur Medical College. Test of 94 came negative in 4 days of giving medicine.
Headline: Deworming medicine ivermectin effective in coronavirus treatment | Corona patients will be treated with De Warming's medicine!
New Delhi: And now the thing about a drug which is very cheap, safe is available in India and it is also working as a treatment on patients of corona virus. This drug is ivermectin.
This drug is being used as a treatment in many cities of Japan, Bangladesh and Bolivia including India. And the results are very satisfying. Japan's PM Shinzo Abe has also decided to try the drug.
Not being used in Japan yet. All Abe said is that Japan will study ivermectin.
Ivermactine, a drug that is part of the World Health Organization's de-worming program, is considered safe in the World Health Organization's Safety List. A medicine which is known as de-worming tablet in the stomach. Now this medicine can be used to cure corona virus. Many hospitals in Kerala, UP, and Delhi in India are also trying this medicine on Corona patients.
In a lab study conducted at Monash University Australia and the Victorian Infectious Diseases Reference Lab, it was found that this drug eliminates the virus within 48 hours. Lab study found that the RNA of coronavirus was reduced by 93 percent with this drug.
However, in this study, the drug was not tried on humans. But this work was done by the doctors of a private hospital in Bangladesh. Doctors of a private hospital in Bangladesh gave iovermactin drug as well as an antibiotic drug doxycycline to 60 corona patients admitted to it. According to the hospital's doctors, after 72 hours of giving the medicine, all the patients got corona test negative.
Actually, ivermactine is considered an antiviral drug to increase immunity. However, if this medicine turns out to be a miraculous drug, a big trial will be needed. But this very inexpensive medicine with no special side effects has given a new hope to the medical world.
Harvard has found in its study that patients are getting corona free from this drug.
Usefulness of... !!!
104 patients were given medicine in Kanpur Medical College. Test of 94 came negative in 4 days of giving medicine. Kanpur Medical is writing a research paper on this medicine.
94/104 sounds much more realistic than Bangladesh's 60/60.
Wasn't Bangladesh 60/60 could have been all relatively mild hospitalised cases of healthy adults (police task right?)?.
We have no idea on what was Kanpur's cases, but judging by these numbers in 4 more days everyone should be in the clear (hopefully).
We need to figure out and test Invermetins maximum dose.
Wasn't Bangladesh 60/60 could have been all relatively mild hospitalised cases of healthy adults
The hospital's staff and the staff's families were the people being treated with ivermectin (plus doxycycline). The report is almost meaningless. To mean, the doc's statement "all 60" means they didn't actually track anything and he just picked a nice round number.
Two sentences from Kanpur is barely news. There's only one report of that out there, AFAIK. Have to wait for more of course.
We need to figure out and test Invermetins maximum dose.
The largest dose being trialed is 600mcg/kg, IIRC. If the trials fail to show positive results, then people will argue that the doses should have been bigger, perhaps -- but I doubt there will be more trials if the initial wave fails.
Could be wrong. I was wrong twice in 1997. Still ashamed. ;)
Plus, I suppose In countries where they use widely use ivermectin we should see a rapid reduction of deaths and active cases (but most counties don't bother updating us about recovered active cases). So that could be a benchmark to go by.
There are a couple towns where they're handing out ivermectin. If that can be done over a very short time period, like 2-3 days, then the before and after rate of growth in infection might be indicative. For a country, though, like Bolivia, I imagine it will take weeks to roll out the drug -- so the infection rate chart won't show an observable inflection.
Could be wrong!
Either way, it's not strong enough evidence to be persuasive in RCT-obsessed places like the US.
Yeah we wouldn't be able to use a whole country, as any changes could be blamed on pandemic naturally phasing it self out and other demographic factors, since it would take a few weeks to hand out the drug.
But if we could find information on a town/small city then that could be useful. Which towns have been handing out the drug?
[-] TrumpLyftAlles | 2 points | May 28 2020 08:14:38
Here are the salient two lines:
104 patients were given medicine in Kanpur Medical College. Test of 94 came negative in 4 days of giving medicine.
Headline: Deworming medicine ivermectin effective in coronavirus treatment | Corona patients will be treated with De Warming's medicine!
New Delhi: And now the thing about a drug which is very cheap, safe is available in India and it is also working as a treatment on patients of corona virus. This drug is ivermectin.
This drug is being used as a treatment in many cities of Japan, Bangladesh and Bolivia including India. And the results are very satisfying. Japan's PM Shinzo Abe has also decided to try the drug.
Not being used in Japan yet. All Abe said is that Japan will study ivermectin.
Ivermactine, a drug that is part of the World Health Organization's de-worming program, is considered safe in the World Health Organization's Safety List. A medicine which is known as de-worming tablet in the stomach. Now this medicine can be used to cure corona virus. Many hospitals in Kerala, UP, and Delhi in India are also trying this medicine on Corona patients.
In a lab study conducted at Monash University Australia and the Victorian Infectious Diseases Reference Lab, it was found that this drug eliminates the virus within 48 hours. Lab study found that the RNA of coronavirus was reduced by 93 percent with this drug.
However, in this study, the drug was not tried on humans. But this work was done by the doctors of a private hospital in Bangladesh. Doctors of a private hospital in Bangladesh gave iovermactin drug as well as an antibiotic drug doxycycline to 60 corona patients admitted to it. According to the hospital's doctors, after 72 hours of giving the medicine, all the patients got corona test negative.
Actually, ivermactine is considered an antiviral drug to increase immunity. However, if this medicine turns out to be a miraculous drug, a big trial will be needed. But this very inexpensive medicine with no special side effects has given a new hope to the medical world.
Harvard has found in its study that patients are getting corona free from this drug.
Usefulness of... !!!
104 patients were given medicine in Kanpur Medical College. Test of 94 came negative in 4 days of giving medicine. Kanpur Medical is writing a research paper on this medicine.
94/104 sounds much more realistic than Bangladesh's 60/60.
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[-] nilaul | 2 points | May 28 2020 19:45:48
Wasn't Bangladesh 60/60 could have been all relatively mild hospitalised cases of healthy adults (police task right?)?.
We have no idea on what was Kanpur's cases, but judging by these numbers in 4 more days everyone should be in the clear (hopefully).
We need to figure out and test Invermetins maximum dose.
permalink
[-] TrumpLyftAlles | 1 points | May 28 2020 19:58:01
Wasn't Bangladesh 60/60 could have been all relatively mild hospitalised cases of healthy adults
The hospital's staff and the staff's families were the people being treated with ivermectin (plus doxycycline). The report is almost meaningless. To mean, the doc's statement "all 60" means they didn't actually track anything and he just picked a nice round number.
Two sentences from Kanpur is barely news. There's only one report of that out there, AFAIK. Have to wait for more of course.
We need to figure out and test Invermetins maximum dose.
The largest dose being trialed is 600mcg/kg, IIRC. If the trials fail to show positive results, then people will argue that the doses should have been bigger, perhaps -- but I doubt there will be more trials if the initial wave fails.
Could be wrong. I was wrong twice in 1997. Still ashamed. ;)
permalink
[-] nilaul | 2 points | May 28 2020 22:49:08
Plus, I suppose In countries where they use widely use ivermectin we should see a rapid reduction of deaths and active cases (but most counties don't bother updating us about recovered active cases). So that could be a benchmark to go by.
permalink
[-] TrumpLyftAlles | 2 points | May 28 2020 22:53:45
Good idea, but that's a tough inference.
There are a couple towns where they're handing out ivermectin. If that can be done over a very short time period, like 2-3 days, then the before and after rate of growth in infection might be indicative. For a country, though, like Bolivia, I imagine it will take weeks to roll out the drug -- so the infection rate chart won't show an observable inflection.
Could be wrong!
Either way, it's not strong enough evidence to be persuasive in RCT-obsessed places like the US.
permalink
[-] nilaul | 2 points | May 28 2020 23:09:56
Yeah we wouldn't be able to use a whole country, as any changes could be blamed on pandemic naturally phasing it self out and other demographic factors, since it would take a few weeks to hand out the drug.
But if we could find information on a town/small city then that could be useful. Which towns have been handing out the drug?
permalink
[-] TrumpLyftAlles | 1 points | May 28 2020 23:16:58
Which towns have been handing out the drug?
I can't remember any names, sorry. Look at the titles in the sub. There are two, IIRC.
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