Int J Antimicrob Agents. 2016 Oct; 48(4): 349–352.
Published online 2016 Aug 5. doi: 10.1016/j.ijantimicag.2016.07.004
Fighting viruses with antibiotics: an overlooked path
In a third study, Varghese et al identified that ivermectin and abamectin were active on Chikungunya virus [17]. Both drugs derive from avermectin, which is produced by the bacterium Streptomyces avermitilis and whose discovery was awarded the Nobel Prize in Medicine in 2015 [30]. Ivermectin and abamectin are macrocyclic lactones with a well-known broad activity spectrum against parasites. Ivermectin is widely used in human and veterinary medicine, whereas abamectin is used on agricultural crops. Varghese et al used a fully automated chikungunya-replicon cell line-based assay to screen a panel of 2933 compounds, which included clinically approved drugs as well as drugs in clinical trials [17]. They found that ivermectin and abamectin inhibited chikungunya virus replication in a dose-dependent manner and decreased the synthesis of genomic RNA, antigenomic RNA and proteins from this virus. In addition, these drugs were also efficient against Semliki Forest virus and Sindbis virus, two other alphaviruses, and on yellow fever virus, a flavivirus, suggesting broad antiviral activity. These three articles are the most recent examples of reports on the antiviral activity of drugs of bacterial origin. Previously, teicoplanin had already been reported as active against HIV, hepatitis C virus, flaviviruses, coronaviruses, respiratory syncytial virus and influenza virus [15]. In addition, ivermectin had been previously shown to inhibit the NS3 helicase of three flaviviruses, namely yellow fever virus, dengue virus and West Nile virus [27] (Table 1). Among other examples of drugs of bacterial origin that are active against viruses, previous works showed the activity of valinomycin, a cyclododecadepsipeptide produced by Streptomyces, against the SARS-CoV [31], and of a bacteriocin produced by Enterococcus faecium against herpes simplex virus [32].
[-] foggynotion | 1 points | May 26 2020 18:50:54
Int J Antimicrob Agents. 2016 Oct; 48(4): 349–352. Published online 2016 Aug 5. doi: 10.1016/j.ijantimicag.2016.07.004
Fighting viruses with antibiotics: an overlooked path
In a third study, Varghese et al identified that ivermectin and abamectin were active on Chikungunya virus [17]. Both drugs derive from avermectin, which is produced by the bacterium Streptomyces avermitilis and whose discovery was awarded the Nobel Prize in Medicine in 2015 [30]. Ivermectin and abamectin are macrocyclic lactones with a well-known broad activity spectrum against parasites. Ivermectin is widely used in human and veterinary medicine, whereas abamectin is used on agricultural crops. Varghese et al used a fully automated chikungunya-replicon cell line-based assay to screen a panel of 2933 compounds, which included clinically approved drugs as well as drugs in clinical trials [17]. They found that ivermectin and abamectin inhibited chikungunya virus replication in a dose-dependent manner and decreased the synthesis of genomic RNA, antigenomic RNA and proteins from this virus. In addition, these drugs were also efficient against Semliki Forest virus and Sindbis virus, two other alphaviruses, and on yellow fever virus, a flavivirus, suggesting broad antiviral activity. These three articles are the most recent examples of reports on the antiviral activity of drugs of bacterial origin. Previously, teicoplanin had already been reported as active against HIV, hepatitis C virus, flaviviruses, coronaviruses, respiratory syncytial virus and influenza virus [15]. In addition, ivermectin had been previously shown to inhibit the NS3 helicase of three flaviviruses, namely yellow fever virus, dengue virus and West Nile virus [27] (Table 1). Among other examples of drugs of bacterial origin that are active against viruses, previous works showed the activity of valinomycin, a cyclododecadepsipeptide produced by Streptomyces, against the SARS-CoV [31], and of a bacteriocin produced by Enterococcus faecium against herpes simplex virus [32].
permalink