Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects

foggynotion | 2 points | May 26 2020 17:41:45

Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects

https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127002237994

[-] okayatarter | 2 points | May 26 2020 23:38:51

Correct me if I’m wrong. Basically this means that a higher dosage than the “fda approved” one didn’t show any adverse side-effects?

[-] foggynotion | 1 points | May 27 2020 00:27:37

So in the handful of studies I've seen where they've used ivermectin for covid its been a one time dose of 3-12mg. In this study:

Subjects (n = 68) were assigned to one of four panels (3:1, ivermectin/placebo): 30 or 60 mg (three times a week) or 90 or 120 mg (single dose). The 30 mg panel (range: 347–594 μg/kg) also received a single dose with food after a 1‐week washout.

tldr; They took a ton of it and was safe even at such high doses

[-] TrumpLyftAlles | 1 points | Aug 10 2020 22:49:40

Yes, 10 times the FDA-recommended 200mcg/kg dose showed no Central Nervous System effects, e.g. pupil dilation.

[-] foggynotion | 1 points | May 26 2020 17:45:24

Just in case articles start popping up that it's somehow dangerous or unsafe this is a good study to reference, as far as I know for covid-19 patients it's been a single dose in the one study I read (3-12mg). In this 2013 study they give people 10 times the approved dosage:

Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA‐approved dose of 200 μg/kg. All dose regimens had a mydriatic effect similar to placebo. Adverse experiences were similar between ivermectin and placebo and did not increase with dose.