This is a literature review, relevant because it asserts that modulation (? reduction) of NF-kB reduces cytokine storms (really rough paraphrase).
This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-kB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-kB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
[-] TrumpLyftAlles | 1 points | May 24 2020 20:42:56
This is a literature review, relevant because it asserts that modulation (? reduction) of NF-kB reduces cytokine storms (really rough paraphrase).
This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-kB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-kB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
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