I overlooked this trial earlier because I didn't know how to get to a trial's details on ClinicalTrialsRegistrer.eu (you click the "ES" to the right of "Trial Protocol". It came to my attention because of one of the researchers tweets today.
It's an exciting study because AFAIK this is the only study looking at ivermectin as prophylaxis.
Lay title: Study of the efficacy of ivermectin in the treatment and prevention of COVID-19
Sub-study 1: Compare the viral clearance in SARS-CoV-2 patients treated with Ivermectin and placebo.
Sub-study 2: Compare the contagion rate between home contacts of patients with COVID-19 + receiving prophylaxis with Ivermectin and placebo
Secondary objective: Secondary objective: Compare the clinical evolution and complications between home contacts of COVID-19 + patients receiving Ivermectin and Placebo prophylaxis.
One of researchers (Dr. Tomas Perez) describes the study on this youtube video. (The video is also available in Spanish.) Summarizing the video very roughly:
Prevention of transmission is important, until a vaccine is available
Ivermectin has been shown to inhibit covid19 in vitro
Why is ivermectin special?
It's been around for 40 years; it's cheap and easy to find;
More than 50 million people have taken it, proving it's good safety profile [more like 1.7 - 3.4 billion!!]
This makes it an ideal candidate
We want to explore two aspects of covid19 transmission:
1) Give patients ivermectin to reduce their viral load and thus reduce their tendency to spread the disease;
2) Give ivermectin to the relatives of or people in direct contact with infected patients, because we believe that ivermectin could prevent them from catching the disease in the early stages.
BreakTheChain
A concern is treatment: AFAIK from the trial details they will dose just one 3 mg tablet. That's very very low. If memory serves, the lowest I've seen in any other trial is 12mg. I tweeted asking about that, no response so far.
A bigger concern is funding. There are soliciting funds and have only raised 8,550 euros of a target of 50,000 euros. Makes me wish I had some money!
On the fund-raising page, it suggests giving ivermectin once or twice a week.
I'm wondering, if it's proven to be an effective treatment, wouldn't that technically by default mean that it's effective if taken as a preventative measure? Also thank you for the information.
I agree, the one implies the other. If it lowers the viral load in the body enough, that would prevent the virus from reaching the point where it affects health -- I wildly guess. THAT is why I am seriously considering self-dosing the drug: I'm high risk about 6 ways and feel like the consequences will be dire if I catch the bug.
[-] TrumpLyftAlles | 3 points | May 21 2020 22:43:59
I overlooked this trial earlier because I didn't know how to get to a trial's details on ClinicalTrialsRegistrer.eu (you click the "ES" to the right of "Trial Protocol". It came to my attention because of one of the researchers tweets today.
It's an exciting study because AFAIK this is the only study looking at ivermectin as prophylaxis.
Lay title: Study of the efficacy of ivermectin in the treatment and prevention of COVID-19
Sub-study 1: Compare the viral clearance in SARS-CoV-2 patients treated with Ivermectin and placebo.
Sub-study 2: Compare the contagion rate between home contacts of patients with COVID-19 + receiving prophylaxis with Ivermectin and placebo
Secondary objective: Secondary objective: Compare the clinical evolution and complications between home contacts of COVID-19 + patients receiving Ivermectin and Placebo prophylaxis.
One of researchers (Dr. Tomas Perez) describes the study on this youtube video. (The video is also available in Spanish.) Summarizing the video very roughly:
We want to explore two aspects of covid19 transmission:
1) Give patients ivermectin to reduce their viral load and thus reduce their tendency to spread the disease;
2) Give ivermectin to the relatives of or people in direct contact with infected patients, because we believe that ivermectin could prevent them from catching the disease in the early stages.
BreakTheChain
A concern is treatment: AFAIK from the trial details they will dose just one 3 mg tablet. That's very very low. If memory serves, the lowest I've seen in any other trial is 12mg. I tweeted asking about that, no response so far.
A bigger concern is funding. There are soliciting funds and have only raised 8,550 euros of a target of 50,000 euros. Makes me wish I had some money!
On the fund-raising page, it suggests giving ivermectin once or twice a week.
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[-] kunkr | 2 points | May 21 2020 22:52:39
I'm wondering, if it's proven to be an effective treatment, wouldn't that technically by default mean that it's effective if taken as a preventative measure? Also thank you for the information.
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[-] TrumpLyftAlles | 3 points | May 21 2020 23:02:32
I agree, the one implies the other. If it lowers the viral load in the body enough, that would prevent the virus from reaching the point where it affects health -- I wildly guess. THAT is why I am seriously considering self-dosing the drug: I'm high risk about 6 ways and feel like the consequences will be dire if I catch the bug.
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[-] lafrase | 2 points | May 28 2020 13:52:38
I`m also thinking about taking a sigle dose every three months of so...
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[-] [deleted] | 1 points | May 21 2020 22:59:46
[deleted]
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