This document is on the FDA site. It appears to have been submitted by Merck in 2007. For some reason it starts on page 3; I can't find a complete version.
Merck distributes (for free) millions of doses of ivermectin to Africa for the treatment of Onchocerciasis (river blindness). STROMECTOL is the brand name for ivermectin.
This is the part that especially caught my attention:
Onchocerciasis
The evaluation of STROMECTOL in the treatment of onchocerciasis is based on the results of clinical
studies involving 1278 patients. In a double-blind, placebo-controlled study involving adult patients with moderate to severe onchocercal infection, patients who received a single dose of 150 mcg/kg STROMECTOL experienced an 83.2% and 99.5% decrease in skin microfilariae count (geometric mean) 3 days and 3 months after the dose, respectively. A marked reduction of 90% was maintained for up to 12 months after the single
dose. As with other microfilaricidal drugs, there was an increase in the microfilariae count in the anterior
chamber of the eye at day 3 after treatment in some patients. However, at 3 and 6 months after the dose, a significantly greater percentage of patients treated with STROMECTOL had decreases in microfilariae count in the anterior chamber than patients treated with placebo.
It appears to establish very long term effects of ivermectin, even though the drug has a half-life of about 16 hours.
The effectiveness increased over time: 83.2% reduction after 3 days, 99.5% reduction after 3 months. The amount of larvae on the skin was 90% lower a year after the single dose.
River blindness isn't COVID-19.
Nonetheless I want to interpret this result as a suggestion that ivermectin has long-lasting prophylactic properties. But then, I'm desperate to find a prophylactic, since I'm high-risk about 5 ways.
[-] TrumpLyftAlles | 1 points | May 12 2020 02:03:35
This document is on the FDA site. It appears to have been submitted by Merck in 2007. For some reason it starts on page 3; I can't find a complete version.
Merck distributes (for free) millions of doses of ivermectin to Africa for the treatment of Onchocerciasis (river blindness). STROMECTOL is the brand name for ivermectin.
This is the part that especially caught my attention:
Onchocerciasis
The evaluation of STROMECTOL in the treatment of onchocerciasis is based on the results of clinical studies involving 1278 patients. In a double-blind, placebo-controlled study involving adult patients with moderate to severe onchocercal infection, patients who received a single dose of 150 mcg/kg STROMECTOL experienced an 83.2% and 99.5% decrease in skin microfilariae count (geometric mean) 3 days and 3 months after the dose, respectively. A marked reduction of 90% was maintained for up to 12 months after the single dose. As with other microfilaricidal drugs, there was an increase in the microfilariae count in the anterior chamber of the eye at day 3 after treatment in some patients. However, at 3 and 6 months after the dose, a significantly greater percentage of patients treated with STROMECTOL had decreases in microfilariae count in the anterior chamber than patients treated with placebo.
It appears to establish very long term effects of ivermectin, even though the drug has a half-life of about 16 hours.
The effectiveness increased over time: 83.2% reduction after 3 days, 99.5% reduction after 3 months. The amount of larvae on the skin was 90% lower a year after the single dose.
River blindness isn't COVID-19.
Nonetheless I want to interpret this result as a suggestion that ivermectin has long-lasting prophylactic properties. But then, I'm desperate to find a prophylactic, since I'm high-risk about 5 ways.
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