TrumpLyftAlles | 2 points
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. - PubMedLet me guess. Another possible COVID-cure enthusiast?
I'm following suit, my friend. Hopeful for an actual working mechanism against the virus with Ivermectin. Trying to get some just in case, too. Just trying to figure out the dosage if it becomes necessary. The document from the Peru doctor is the safest bet right now, I guess.
Let's just hope it all goes well.
[-] TrumpLyftAlles | 1 points
Another possible COVID-cure enthusiast?
Guilty! :)
Trying to get some just in case, too.
$7 at Amazon for the horse paste variety. Two doctors turned me down for a prescription.
Just trying to figure out the dosage if it becomes necessary.
If you google "ivermectin scabies horse paste" the top link is a guy who self-dosed the horse paste variety for scabies. He has a page showing the dosage math and a video about how to operate the "syringe" (it's not a syringe) that the paste comes in.
The document from the Peru doctor is the safest bet right now, I guess.
Not sure which one that is? Are you looking for the recommended mcg/kg?
Are you following this guy's self-dosing, going on right now?
https://www.reddit.com/r/ivermectin/comments/gdggcl/i_have_covid19_and_will_be_attempting_to/fqecws0/
Guilty! :)
Yay, another one! I've been following EVERYTHING regarding this drug since the SSRN papers of the In Vivo studies released.
Nice to have a fellow investigator, lol :)
$7 at Amazon for the horse paste variety.
Seems that we don't have that variety in here :( Looked everywhere for it too but to no avail. We only have the human-use tablets and they're only strictly sold via prescription :(
Fortunately (?), I've had some scabies-like rash symptoms (stress, amirite?) and I had a box prescribed already, lol
Still, it's not enough for my family. I'm mostly looking out for them, as I don't have any underlying conditions. Ugh, hopefully we'll figure it out, lol
Not sure which one that is?
It's this one. It's a translation though. The original document is on the doctor's LinkedIn, though it's in spanish, of course.
He shares the dosage he's been using corresponding to the weight and the case's severity and duration per symptomatology, as well as some examples of cured patients. Amazingly he's not had a single death, though it's still a very small group he's managing (40 people from what the document tells and 80 from his LinkedIn updates).
Still, the collective success cases of Ivermectin do tell us something, I feel.
There's also a fight going on in Bolivia. Doctors who've found success in Ivermectin have fought to get the government to make it a first-line medication, but the government has basically prohibited Ivermectin saying that it's a vet drug that shouldn't be self-prescribed. Weird that they're basically ignoring everything regarding its effectivity, and especially that there's a human version too?
Here's a spanish link for that. Couldn't find an english source, sorry.
Those Bolivian doctors have also done interviews and recorded videos for more visibility. I've those, too, but again, spanish only, of course. Do tell if you need the source for those, though.
[-] TrumpLyftAlles | 1 points
This is the dosing guidance you mean?
Presentation: 6mg tablets.
If it weighs between 80 to 110 Kg: give 3 tab. daily x 2 days.
If it weighs more than 110 Kg: give 4 tab. daily x 2 days.
I think that's close to the 200mcg/kg standard that the FDA established and a lot of the studies are following.
I posted this thread to twitter a couple hours ago.
There's also a fight going on in Bolivia. Doctors who've found success in Ivermectin have fought to get the government to make it a first-line medication, but the government has basically prohibited Ivermectin saying that it's a vet drug that shouldn't be self-prescribed. Weird that they're basically ignoring everything regarding its effectivity, and especially that there's a human version too?
There's an obvious counterargument: literally billions of doses of ivermectin have been taken by people, esp. 300 million a year in Africa for the treatment of river blindness.
I chanced across this on twitter.
The doctor Herland Vaca Díez defended the efficacy of ivermectin in the treatment against coronavirus. He held a meeting with the Medical College of Santa Cruz on Tuesday afternoon.
Oh, and adding to the previous comment, yeah, I've been keeping an eye on him! I've just now realized you're one of the active users there as well, lol
Idk how I feel, I'm feeling kinda let down by the updates he's been doing, but he does have a point (as do you) that the long term damage of the virus might be what's affecting more right now. Perhaps Ivermectin is only effective in the first stages.
Hopefully he gets way better soon, Ivermectin or not. He deserves it!
[-] TrumpLyftAlles | 2 points
I'm feeling kinda let down by the updates he's been doing
What? Not me.
I've been suffering with severe shortness of breath, fatigue, cough, sore throat, congestion, chest pains, random limb pain, tingling sensations in face and limbs, diarrhea alternating with constipation, flushing/red face, tachycardia alternating with bradycardia, and splitting headaches off and on since the middle of March (45 days total now).
He hasn't answered my question yet, but he hasn't mentioned any of those in his daily updates. It's still early, but I'm thinking he's cured with possible lung damage. Hopefully his shortness of breath will go away too.
Perhaps Ivermectin is only effective in the first stages.
It's just an anecdote, but the Dominican Republic MD who reported great success with 460 patients said he brought back someone from the verge of death with ivermectin.
Ugh, you're so right. Perhaps I was waiting for an all-curing pill that would make every single symptom of his go away real soon. Anxiety and naivety betray me, haha
It does seem encouraging, now in retrospective. Again, seems like the drug might be way more effective on earlier days to prevent organ damage.
It's just an anecdote, but the Dominican Republic MD who reported great success with 460 patients said he brought back someone from the verge of death with ivermectin.
Do you have a source for that? I only read it on an encouraging Reddit comment as far as I remember but never on an actual site. It does sound very encouraging, though!
Thanks man, I guess I needed to "vent" about that post to open more my perspective, haha
[-] TrumpLyftAlles | 1 points
seems like the drug might be way more effective on earlier days to prevent organ damage.
Have you heard about this? If it works, you'll insert some tech under your skin and it will emit ivermectin for 3 months -- to prevent you from catching the disease.
I also take heart from the amazing magical prophylactic properties of ivermectin against parasites, e.g. river blindness skin larvae are reduced more than 90% a year after a single 150mcg dose!
Here is the DR MD. I've only been on twitter for about three weeks; this article is my only tweet that draws any notice.
I guess you're aware of the Miami MD who has been including ivermectin in his covid cocktail?
I needed to "vent" about that post to open more my perspective
The brave self-doser worked for me, almost, maybe. I have had the horse paste ivermectin for about three weeks, and I'm close to having the confidence/terror to start taking it twice a week, hoping it's prophylactic. I'll post to \r\ivermectin if I do. It won't be interesting, though, because I have no symptoms.
If the gadget-in-the-skin works, which is completely unknown thus far -- then so should self-dosing horse paste. Bill Gates thinks it may work. That's good enough for me.
I appreciate your concern for your parents; you're a good son. Mine passed a few years ago at ages 93 and 94. I'm not certain that I'll make my September birthday: 67, BMI 30.1 obese, hypertensive, diabetic, blood type A, male, very socially isolated, and still weak after injuries to both legs that put me in a hospital bed for two months. I am fairly certain that I'll die if I catch the virus. So I am super-isolating, and as of today I'm fasting! About 26 hours since I last ate. Autophage! (not sure what that is, but it's good.) 180 pounds by September! If I'm not eating, my only outings other than walks in the sun and monthly trips to the pharmacy.
Wish me luck!
If I stop posting, then you should request becoming a /r/ivermectin moderator.
Ooh, that was a little dark. ;)
See you in the sub.
BTW, I'm also talking with a Bolivian living in New York who took a self-prescribed Ivermectin dosage from a vet "syringe" like the one you told me, and it seems like it cured him. He's now commenting on YouTube videos giving his advice and trying to make others understand that Ivermectin's a real deal.
He didn't test but he took it when he felt a very odd flu, and it cured him. He also says he recommended it to some actually tested positive friends and it also worked.
AND then he gave me even more testimonies of people who've taken it, some from Brasil that he had to Google Translate.
Mind you that he's a random on YouTube comments and we're talking in spanish, so it's all very unofficial right now of course, but I'll try to get more info on/from him. No amount of hope can be enough!
Have you heard about this?
Yeah! It does seem like it'd be a pretty useful treatment! Still, I didn't really think of it that much since it's still a long (enough) way ahead of us. I prefer to stick with what we already have at hand, haha
Here is the DR MD
Oh, awesome! Thanks for sharing! My god, with each new article my hopes grow stronger, haha, seems like we have an actual, functioning cure just pulled back by money to be won on actual patent medicines. Just my tinfoil hat talkin maybe, lol
And yes! I've also been aware of the Miami MD! Still, I also tend to ignore the cocktails and similar right now, haha
I'm only eager for Ivermectin to work because of its high safety margin, the other medicaments scare me! Plus it's encouraging to see Ivermectin working well enough on its own in other studies.
I'm close to having the confidence/terror to start taking it twice a week.
That's what I mean. At least you naturally have the courage to maybe try this if needed. HCQ on the other hand and as an example, would be very frightening! Still, just follow your instincts. Hopefully it isn't ever needed for you, but at least we got the full spectrum of its power.
I appreciate your concern for your parents; you're a good son. Mine passed a few years ago at ages 93 and 94.
Aw, thanks! Hopefully they are never touched by the virus, or at least I hope Ivermectin is our miracle just in case.
I'm sorry to hear about your parents though. I hope you're doing fine enough after that experience.
I'm not certain that I'll make my September birthday
I'm completely rooting for you, and I'm sure we'll be celebrating the success of this med after and even before that date, with you as a mod of course, haha! I'm happy to know you're doing good enough right now. Best of luck on your own journey through this pandemic!
And hey, I might be a third of your age and live far away in Mexico, but if I can do anything to help you out either with this whole investigating Ivermectin thing, or anything else, just give me a heads up, ok? You seem like a great person. :)
See you in the sub!
What about the fact that all horse paste says in bold “FOR EQUINE USE ONLY?” What else is added in there and how would you make sure it’s safe for human consumption?
[-] TrumpLyftAlles | 1 points
Thanks for the excellent question! It made me look up the Material Safety Data Sheet for the horse paste.
The other ingredients are pigment (< 5%), thickening agents (15%), and vehicle solvent (bal) (?). None of those have a classification as toxic or not. Ivermectin is "Toxic" in the ingredients list.
I'm not alarmed, how about you?
This stuff is fed to lots of agricultural animals: horses, cattle, pigs, chickens, pet birds, ... Pigs are good human analogs used in a lot of medical research for that reason. I'm confident that its manufacturer wouldn't include ingredients harmful to life. "Gee, Chuck, why don't we throw in this stuff that will only kill a few horses?"
You probably already realized that "for equine use only" (don't want to shout at you!) is on the package because the paste isn't meant for people. I imagine some government authority like the FDA requires that warning.
Beyond that, I'm aware of a number of people who have eaten horse paste because it's so much cheaper than the prescription pills and/or they cannot get a prescription from their doctor. (Damn, I can't find the meme complaining about the cost discrepancy: the prescription drug is hundreds of times more expensive, IIRC.)
One guy used the horse paste to treat his own scabies. His web page has phrases like "I get a lot of questions about..." (roughly, from old memory) which implies that it's not just him. IIRC, he added a page on the math for calculating the proper dose and a link to a youtube video he created about measuring out the dose, in response to questions from readers.
There are 18 posts to \r\scabies that mention horse paste. I didn't read them to check how many of the posters actually ate the horse paste, but that's how you would use it to cure scabies. Works! The CDC acknowledges that ivermectin is effective for scabies, while not officially approving the drug.
LOL: While I was writing this post, this was posted to this study's conversation:
BTW, I'm also talking with a Bolivian living in New York who took a self-prescribed Ivermectin dosage from a vet "syringe" like the one you told me, and it seems like it cured him. He's now commenting on YouTube videos giving his advice and trying to make others understand that Ivermectin's a real deal.
He didn't test but he took it when he felt a very odd flu, and it cured him. He also says he recommended it to some actually tested positive friends and it also worked.
AND then he gave me even more testimonies of people who've taken it, some from Brasil that he had to Google Translate.
I didn't find it, briefly searching the coronavirus subs, but during one conversation about ivermectin a Brazilian guy said that it's sold in drug stores there (I think he said that) and he gave it to his 5-year-old daughter for scabies -- and she's fine. He might have been talking about ivermectin for humans, I can't remember for sure.
IMO a preponderance of the evidence is that horse paste ivermectin is safe for human consumption.
Seriously, do not resort to the horse paste unless you have no alternative.
I am super-high-risk: old, fat, hypertensive, diabetic, male, type A blood, weak from a December injury that put me in a hospital bed for 8 weeks that still inhibits my ability to walk very far. I can't persuade an MD to prescribe it for me. I want to continue living so I can attend my 13-year-old's wedding someday and spoil my two sons' eventual children. I'm desperate.
For not great reasons, I think that ivermectin may have prophylactic properties, may prevent me from catching covid.
So given my high high risk and strong desire to live, I'll probably start self-dosing sometime soon.
Please do NOT do that, period, reddit friends.
What do you think? Convinced the horse paste is safe?
[-] TrumpLyftAlles | 1 points | May 11 2020 21:47:26
The primary safety endpoint was mydriasis, accurately quantitated by pupillometry. Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg.
2000 mgc/kg = 907 mcg/pound = 200 mg for a 220 pound person
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