Evidence that human-tolerable doses of ivermectin kills bedbugs:
Recently, the same group, led by Dr. Johnathan Sheele, has published an update on their efforts in the Journal of Parasitology Research. In a series of trials, they have fed bedbugs on blood containing a dose of ivermectin more in line with what is expected to be in the blood after a single treatment of the FDA-approved formulation. Then they observed these bed bugs for several months to see what percentage of them die, or recover to be able to reproduce.
They have found that this more realistic dosage was still sufficient to paralyze and ultimately kill bedbugs, as in each trial with ivermectin blood concentrations above 25 ng/mL at least 50% of bedbugs died. Even at lower concentrations, but above 2.5 ng/mL, bedbugs suffered long-term effects such as reduced fecundity, feeding difficulty, and incomplete molting.
Most relevant:
Dr. Sheele and his team are proposing a novel dosing regimen in order to keep ivermectin levels at 20-25 ng/mL for about 2 weeks, allowing all bed bugs to be exposed to toxic levels of the drug.
It's not proof but it implies that a regimen of ivermectin maintenance is safe.
[-] TrumpLyftAlles | 1 points | May 11 2020 21:33:17
Evidence that human-tolerable doses of ivermectin kills bedbugs:
Recently, the same group, led by Dr. Johnathan Sheele, has published an update on their efforts in the Journal of Parasitology Research. In a series of trials, they have fed bedbugs on blood containing a dose of ivermectin more in line with what is expected to be in the blood after a single treatment of the FDA-approved formulation. Then they observed these bed bugs for several months to see what percentage of them die, or recover to be able to reproduce.
They have found that this more realistic dosage was still sufficient to paralyze and ultimately kill bedbugs, as in each trial with ivermectin blood concentrations above 25 ng/mL at least 50% of bedbugs died. Even at lower concentrations, but above 2.5 ng/mL, bedbugs suffered long-term effects such as reduced fecundity, feeding difficulty, and incomplete molting.
Most relevant:
Dr. Sheele and his team are proposing a novel dosing regimen in order to keep ivermectin levels at 20-25 ng/mL for about 2 weeks, allowing all bed bugs to be exposed to toxic levels of the drug.
It's not proof but it implies that a regimen of ivermectin maintenance is safe.
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