MayorEricBlazecetti | 11 points
I have COVID19 and will be attempting to self-treat with Ivermectin this week[30/m/USA]
I'll be attempting to self-administer Ivermectin (the horse-oriented paste picked up from Amazon) this Wednesday when it arrives. I'll be posting updates here as edits to this post.
I'm doing this because I don't feel my symptoms are improving after 45 days of suffering and I've lost all hope in our medical system. No doctor I speak to seems to have any idea on what's wrong with me yet there's no urgency to figure it out as "it's probably COVID." Since there's no treatment, all I can get is an inhaler and a "good luck."
Background/symptoms:
I've been suffering with severe shortness of breath, fatigue, cough, sore throat, congestion, chest pains, random limb pain, tingling sensations in face and limbs, diarrhea alternating with constipation, flushing/red face, tachycardia alternating with bradycardia, and splitting headaches off and on since the middle of March (45 days total now). All the above symptoms come and go in waves with the exception of the shortness of breath being constant (though the severity modulates, worse at night usually).
COVID Test Results:
Studies from Germany are showing that late-infection swab tests (my first was 3 weeks into my illness) have over an 80% false negative rate while blood and stool samples still return positives. I'm assuming this is what's happening for me. My doctor says they will be trying to get me in for an antibody test soon.
I took one dose (12mg pills) of it this saturday (may 9th) after being sick for 11 weeks and reading that in a lot of Latin American countries they are having great success with it.
Fortunately, in my country (Mexico) they sell the pills without prescription for lice and parasites. So I bit the bullet and took that 1 dose on Saturday.
Sunday I was super tired, slept a lot during the day and my stomach got very upset (burning sensation). Sunday afternoon (after all day sleeping) I felt GREAT . SoB was almost gone, and I felt with a bit of energy.
Monday was OK. SoB returned and again I was tired. Monday night I felt a bit better and slept well.
Tuesday (today) i woke up with a bit more energy. SoB is deffinitely better, but not as good as Sunday ... I'm thinking on getting another 12mg dose.
: https://acento.com.do/2020/salud/8814342-a-paso-de-vencedor-tratamiento-de-covid-19-con-ivermectina-en-puerto-plata-y-punta-cana/amp/?__twitter_impression=true
https://mobile.twitter.com/Gorelambayeque/status/1258966687216316416/photo/2
https://drive.google.com/file/d/14s9kcEkdw4MEvBzXOPLiIsmYXsbaMYZM/view
update :
So after taking the 12g ivermectin pills on Saturday, I deffinitely felt better on sunday through Tuesday. The only thing is that I felt Very tired on sunday (it is a secondary effect of ivermectin).
Today Wednesday May 13th I started feeling worse again: SOB , funny sensation in the lungs, woke up with a "'hungover" feeling (like having been punched all night).
So I took another 12gr if Ivermectin. After just a out 2 hours of taking it my symptoms improved. Again I became sleepy and tired, but my SOB went away. ...
Hopefully I stay better for more time this time.
For reference I'm a 38yo male. Non smoker and have had Covid since 1st week of March.
Thursday 14 may night: I deffinitely feel better, but similarly the SoB is the symptom that remains... my lungs will have to get stronger. Hopefully with time.
I found that in Peru, the dose of ivermectin for "mild/moderate" cases is 12g once a day for 2 days... I took that but left a 3 day space. It seems to be helping me. I'll keep updating.
[-] TrumpLyftAlles | 3 points
Thanks so much for posting this, telling us how ivermectin is working for you!
You were sick with covid-19 for a long time! 11 weeks! Ugh. Sounds miserable.
Did you have symptoms other than SoB? It appears that OP may be done with all his symptoms except SoB.
Please keep us posted with your progress.
Good luck!
[-] movethroughit | 2 points
Did you see the info about Dr. Richard Neel and melatonin?
It seems it might have a positive impact on fibrosis as well as other benefits:
https://devinenews.com/dr-neel-a-pioneer-in-treating-covid-19-patients-with-melatonin/
Doctors at Doctor's Hospital in Manila are using it as well (perhaps combined with hydroxychloroquine). Helps regulate NLRP3 inflammasomes, antioxidant, much more. Some research on melatonin and pneumonia might be worth looking into.
[-] okayatarter | 4 points
You’ll love this. And I’ll pray for you.
https://english.mathrubhumi.com/news/good-news/after-48-days-of-treatment-shirley-defeats-covid-19-1.4715616
(Please do let us know how it goes. I’m hoping on this one. Try to get your blood flow across your body, maybe by massage or just some yoga postures or anything. Naive advice maybe, but just wished to share thoughts. Ignore if doesn’t make sense.)
[-] MayorEricBlazecetti | 2 points
I've taken the drug and have begun updating this thread 👍
[-] okayatarter | 1 points
I’m wishing for you bro! Keep taking water, btw. It’s gonna work! :)
Dude, just so you know and if that's the case and not just a figure of speech of yours, it shouldn't be the Horse Paste that you should administer. (What would be your doses for that anyway?)
The ones that you'd be trying out are the human-approved tablets. 150 or 200 mcg/kg, single dose. The approved dose for parasites that's been working on that one study.
Mind you that it's only possible because of Ivermectin's safety range. You shouldn't go around trying to self medicate in any other instance. But at least in this one it's a safe enough medication. But again, the human approved tablets.
[-] MayorEricBlazecetti | 3 points
The vendor I bought from lists the exact dosage of pure active and inactive ingredients on their website. I can do the math. You’re right that you need to be careful of this, but that’s why I’m doing my homework. I’m aware of the risks entirely, but I’m willing to take them for the sake of educating others.
I’ll follow up with the brand/SKU, specs, and my dosage later this week.
Ok, just wanted to make sure you were safe.
That settled then, I’m interested in this. Will follow this case! Best of luck!
[-] MayorEricBlazecetti | 2 points
[-] TrumpLyftAlles | 2 points
While laying flat or even slightly elevated with a wedge, difficulty breathing is much much worse and I struggle to keep my O2 above 94%, while chest/shoulder/arm pains come and go and keep me awake.
Can you sleep on your stomach? Hospitals have found that patients do better prone than they do on ventilators.
[-] TrumpLyftAlles | 2 points
Here a guy tells about self-administering the horse-paste form of ivermectin to treat his scabies.
[-] TrumpLyftAlles | 2 points
If you are interested learning more about ivermectin esp. keeping up with related research, here are a couple subs where I and others post ivermectin research. The first is more academic.
On twitter, follow @carlos_chaccour #ivermectin
Carlos maintains lists of studies and reports of various types: preprints, journal articles, news stories, etc.
You're all welcome in the covid subs!
Are there any resources I should know about?
Hey, me again, how're you doing, pal?
[-] MayorEricBlazecetti | 3 points
Doing really good today! Just posted another edit.
That's good to hear, I hope you continue to feel better, best wishes and take it easy.
Amazing news! I take that the viral symptoms diminishing is something you didn't really experience in that quantity before, then? That's great!
Hope the drug does wonders soon! Good luck in your Monday appointment and with these days in general!
[-] MayorEricBlazecetti | 2 points
No, I’ve definitely felt better turns before... you know, the way this thing hits in waves.
I’m cautiously optimistic, but let’s wait and see. I’m still planning on hitting a redosage at 14 days from initial dose.
[-] TrumpLyftAlles | 2 points
Posting so I can find this good news later. Please keep updating your experience! Congratulations on feeling better!!
May 08, 2020 * 9:00am - Slept like a rock last night. I woke up feeling really good. Breathing last night was easy and I only woke up once in the night with mild SoB. I'm feeling surprisingly good right now.
[-] TrumpLyftAlles | 2 points
Have you taken a second dose?
Have you read this article by a guy self-dosing with the horse paste variety to treat his scabies? He recommends taking it a couple times a week, based on this chart from Merck showing the drug's half-life.
[-] MayorEricBlazecetti | 2 points
I was planning on dosing a second time at the 14 day mark similarly to the testing being done by doctors right now for the drug. I may try a second dosage sooner though.
[-] TrumpLyftAlles | 1 points
Which study are you talking about that did a second dose 14 days later?
There are multiple stories about ivermecton being dosed more often. Here is a reddit threat about one:
He explains that the patients were divided for dosing purposes into two groups: those who were less than 80 kg in weight and those who were over 80 kg in weight, “the first we gave Ivermectin 6 mg 2 tablets, the second Ivermectin 6 mg, 3 tablets, to make the administration of the medications based on the kg of weight more practical, regardless of whether they were in classification or phase 2 or classification or phase 3 of the disease ”
To all, he explains, he administered a single dose per day, repeating doses after 24 hours, without exceeding 36 mg.
It's a very safe drug. This MD has treated 460 patients without difficulties -- if you believe him. It's very far from a rigorous study.
You seem to be stuck. Maybe another dose would help.
Easy for me to say, of course, sitting at my keyboard. Please forgive me if I go to far.
[-] MayorEricBlazecetti | 1 points
Alright you convinced me. I just redosed another 22mg. Added in an edit above too.
[-] TrumpLyftAlles | 1 points
I hope you sleep well, friend.
Interested in how the second dosage acts out. Once more, glad you’re doing good!
Keep on keeping on!
[-] TrumpLyftAlles | 2 points
* Redosed on Ivermectin at 200mcg/kg. * No side-effects this time so far, but I took it after a meal unlike last time which was on an empty stomach. * Ended up with no noticeable side-effects from the second dosage. * May 10, 2020 * Slept like A ROCK last night. 9.5hrs of sleep with no disturbance. * 10:50a - Breathing feels only mildly short today. I'm bringing up a lot of yellowish phlegm today which I'll take as a good sign. My lungs feel really good overall and I don't feel any other symptoms.
FABULOUS NEWS! Good for you, man! :) :)
[-] TrumpLyftAlles | 2 points
No update today? I hope you're well. I hope you're fully recovered.
I chanced across this study that discusses getting rid of bedbugs by (the human) taking ivermectin. The drug paralyzes some bugs, others fail to reproduce. From that article:
Dr. Sheele and his team are proposing a novel dosing regimen in order to keep ivermectin levels at 20-25 ng/mL for about 2 weeks, allowing all bed bugs to be exposed to toxic levels of the drug.
I also came across this study "Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects."
Ivermectin was generally well tolerated, with no indication of associated CNS toxicity for doses up to 10 times the highest FDA-approved dose of 200 microg/kg.
[-] MayorEricBlazecetti | 6 points
Updated, sorry for the slow stream - it's tough to get the updates in during the working week while fighting this bug.
Symptoms are coming back, so I'm redosing with 100mcg/kg and switching to an every-other-day cadence. Maybe a steadier stream of medication will give my body the sustained help it needs to fight this off. I'm definitely feeling better after I take the drug, but it doesn't seem to last.
[-] TrumpLyftAlles | 2 points
Sorry to hear that you seem to be regressing. I think that every other day makes sense!
Feel better tomorrow!
[-] [deleted] | 2 points
May 12, 2020 * Slept really well last night despite the difficulty breathing. It let up just enough before falling asleep that the rest of my insomnia-induced fatigue let me crash hard. I didn't wake up once last night. * 10:00am: Continued mild shortness of breath persisting from last night
A good night's sleep is a blessing! Even if it is the result of sleep-deprivation. "Mild" seems better?
I've been suffering with severe shortness of breath, fatigue, cough, sore throat, congestion, chest pains, random limb pain, tingling sensations in face and limbs, diarrhea alternating with constipation, flushing/red face, tachycardia alternating with bradycardia, and splitting headaches off and on since the middle of March (45 days total now).
How are your other symptoms doing?
All the above symptoms come and go in waves with the exception of the shortness of breath being constant (though the severity modulates, worse at night usually).
Would you say that your shortness of breath is improved (if still a problem)?
I hate to say it, but you might have lung damage?! I wonder if an oxygen concentrator might be helpful. Not cheap: $410. You could buy one and return it if it's not helpful. I didn't do any shopping, just picked one; there are probably better deals out there.
[-] markartur1 | 2 points
Hey, how is it going?
[-] douggie_88 | 1 points
No update for 2 days...that can't be good 😬
[-] Mexloco2021 | 1 points
I hope he is ok
[-] rosenbergstein | 1 points
You should set up some form of "dead man switch" to post on reddit in case you die or become incapacitated.
But yes, a lot of people are doing what you're doing, even doctors. Good luck, buddy
Everything ok there, buddy?
[-] MayorEricBlazecetti | 3 points
Everything's good! Continued updates. Last night was rough but I'm fairly certain it has nothing to do with the medication.
Good to know! Got a little worried there, haha
Just a heads up, just in case: A doctor in Peru is trying the Ivermectin in one dose for two days for Moderate patients. He's treated only slightly over 40 patients with it but he's had a 0% mortaity rate thus far and says the symptoms of Moderate patients is reduced from 12 to 48 hours after the first dose.
Mind you that the document is a translation from spanish, that's why there're typos. If you want the OG spanish source let me know.
[-] MayorEricBlazecetti | 2 points
Neat, thanks for sharing. I might switch to daily updates instead of whenever I feel. It looks like this drug works for about 14 days after one dosage so it'll take some time to really see the effects.
Make sure you are getting enough vitamin D from supplement or sunlight (aim to get 10–30 minutes of midday sunlight). There is a reason why countries with more sunlight are seeing a lower CFR, vitamin D may be why. I wish you the best, I hope you begin feeling better soon, there are many good things on the horizon.
Hey! How’s things going today? Everything good?
[-] MayorEricBlazecetti | 1 points
Updated - expect slower updates over the week as I try and get back to work
[-] jasonschwarz | 5 points | May 05 2020 03:36:40
One caveat... a tube of horse paste has the specified total amount, but it's not necessarily well-blended... especially if it's old, or was stored under less than ideal conditions.
The dosage for a foal-vs-horse might be close enough if you're talking about a half-syringe vs a full one, but might vary widely from dose to dose if you're squeezing out a gram of paste at a time & expecting each to contain a precise fraction of the total amount. One might have almost no ivermectin, while the next might have 2-4x the expected amount. It's not likely to be overdose-dangerous, but COULD mean you're effectively taking doses that are basically just a placebo, randomly alternating with double or triple doses.
The moral: eject the syringe into a container, and mix it thoroughly. Don't assume it's consistently mixed as it comes out of the tube.
Tip: injectable (10mg/mL) ivermectin doesn't have to be injected... you can draw out the desired amount with a syringe, squirt it onto a spoon, and take it orally. It tastes kind of like generic guaifenesin syrup... not great, but not awful. And a 50mL bottle has enough to keep you prophylactically supplied for more than 6 months.
Also, Stromectol (the FDA-approved human form sold in the US) only comes in 3mg tablets, but if you buy generic tablets from an overseas pharmacy, you can probably get it in 6mg, 12mg, and possibly 18mg tablets as well.
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[-] MayorEricBlazecetti | 2 points | May 05 2020 04:23:32
This is really really good to know (mixing the paste), thanks for the heads up. I'll be sure to do it.
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[-] TrumpLyftAlles | 1 points | May 06 2020 21:30:58
And a 50mL bottle has enough to keep you prophylactically supplied for more than 6 months.
Prophylactically, to prevent catching covid? Or some parasite? How often would you dose with ivermectin, to prevent the disease?
I'm asking because I am super-high risk, looking for anything that will help me not catch covid, and have a couple of boxes of 1.87 horse paste. So far I haven't really focused on taking it. Don't want to wait until it's too late.
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[-] jasonschwarz | 2 points | May 07 2020 05:18:01
Covid. The million-dollar question right now is, if you're taking it prophylactically at 0.2mg/kg, is it more beneficial to take the full dose once per week, or to divide it up into more frequent doses that add up to the same total amount per week. I honestly don't know.
I've personally been taking 5mg (0.5mL @ 10mg/mL) every other day, on the theory that it's probably better to maintain a somewhat stable amount than to have most of it metabolize away between doses... but until some proper studies get published, it's all educated guesswork anyway. As luck would have it, 5mg/twoday x 3.5 twodays/week comes out to 17.5mg/week. My calculated 0.2mg/kg dose is 17.4mg, and ivermectin's safety range is fairly wide, so I think that works out almost perfectly. By alternating days, I'm re-dosing after slightly more than 2 half-lives (so it never completely goes away), but still having a tiny spike every other day for a few hours just in case it ends up being a case where a higher concentration actually makes a difference.
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[-] TrumpLyftAlles | 1 points | May 07 2020 16:57:21
Brilliant. Not sarcasm. Thanks a lot!
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[-] TrumpLyftAlles | 1 points | May 09 2020 20:30:16
if you're taking it prophylactically at 0.2mg/kg, is it more beneficial to take the full dose once per week, or to divide it up into more frequent doses that add up to the same total amount per week. I honestly don't know.
Have you read this article by a guy self-dosing with the horse paste variety to treat his scabies? He recommends taking it a couple times a week, based on this chart from Merck showing the drug's half-life.
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[-] TrumpLyftAlles | 1 points | May 11 2020 22:14:30
My calculated 0.2mg/kg dose is 17.4mg
Can you show me your math please?
2mg/kg = 0.9072 mg/pound
17.4 mg / 0.9072 = 19.17 pounds.
You weigh a lot more than 19 pounds, I trust? Or is my math wrong?
Here I calculate that 200mg is a safe human dose.
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[-] jasonschwarz | 2 points | May 12 2020 07:26:14
The usual dose is 0.15 to 0.2mg/kg. I'm 87kg.
192lb = 87kg
87kg x 0.2mg/kg = 17.4mg
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[-] TrumpLyftAlles | 1 points | May 12 2020 07:39:28
Shit.
I got a perfect 800 on the math part of the GRE -- 45 years ago. Now I can't do simple math. Your math looks fine; I trust it more than my own. I don't know what's wrong with mine, though.
Sigh: not as bright as I used to be.
Thanks for your reply -- esp. not calling me an idiot.
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[-] TrumpLyftAlles | 1 points | May 06 2020 21:36:13
it's not necessarily well-blended
Do you have any basis for this opinion?
IMO this sounds very unlikely. It's not like they fill the tube with inactive ingredients, add the ivermectin, and shake. I'm 100% certain, even though I have no facts, that it is blended in a very large quantity before it heads to the packaging part of the production line.
But I'm delighted to be wrong, if you have some actual information.
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[-] jasonschwarz | 2 points | May 07 2020 04:30:46
I don't remember where I saw it, but someone said that it's well-blended at the time it's made, but the density of ivermectin isn't absolutely identical to the density of the paste, so over time, they gradually separate apart... the lighter one floats upwards, the denser one sinks. If it were stored horizontally, it might not matter much. If it were stored vertically (say, packed in a box, along with other boxes, that was "wrong side up" for an extended period of time), it might. If it were stored vertically at warm temperatures that caused the paste to become more liquid, it could matter a lot.
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[-] TrumpLyftAlles | 1 points | May 07 2020 16:58:21
so over time, they gradually separate apart... the lighter one floats upwards, the denser one sinks
That makes sense. Thanks for your excellent answer to skeptical me.
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